Gi3 - CysLT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 132 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 I 132 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 R 121 3x50 G.H5 L 353 G.H5.25
Polar H8 N 301 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 N 301 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 301 8x49 G.H5 K 349 G.H5.21
Polar H8 G 299 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 299 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 216 5x65 G.H5 L 348 G.H5.20
Polar TM6 N 224 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 224 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 224 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 132 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 K 223 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 223 - G.S6 Y 320 G.S6.02
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 125 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 I 344 G.H5.16
Polar ICL2 N 133 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 133 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 M 234 6x37 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 234 6x37 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 128 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 128 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 I 132 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 132 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL3 K 219 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 K 219 - G.H5 I 344 G.H5.16
Hydrophobic TM3 A 124 3x53 G.H5 C 351 G.H5.23
Polar TM6 S 227 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 S 227 6x30 G.H5 Y 354 G.H5.26
Ionic C-term E 333 - G.H3 K 248 G.H3.07
Polar C-term E 333 - G.H3 K 248 G.H3.07
Van-der-waals C-term E 333 - G.H3 K 248 G.H3.07
Polar H8 G 300 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 G 300 8x48 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 V 129 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 129 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 F 58 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 58 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 231 6x34 G.H5 L 348 G.H5.20
Hydrophobic C-term V 337 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term V 337 - G.s1h1 G 40 G.s1h1.01
Polar ICL2 N 131 34x53 G.H5 N 347 G.H5.19
Ionic H8 K 304 8x52 G.h3s5 E 261 G.h3s5.02
Polar H8 K 304 8x52 G.h3s5 E 261 G.h3s5.02
Van-der-waals H8 K 304 8x52 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM3 I 125 3x54 G.H5 N 347 G.H5.19
Polar TM6 A 231 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 231 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 231 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 M 234 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 234 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 235 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL3 K 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term V 337 - G.H2 R 208 G.H2.04
Van-der-waals C-term V 337 - G.H2 R 208 G.H2.04
Polar TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term K 336 - G.s4h3 E 236 G.s4h3.10
Hydrophobic ICL2 V 129 34x51 G.H5 F 336 G.H5.08
Polar C-term V 337 - G.s3h2 G 203 G.s3h2.02
Polar ICL3 K 223 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 K 223 - G.S6 I 319 G.S6.01
Hydrophobic C-term V 337 - G.H3 L 249 G.H3.08
Van-der-waals C-term V 337 - G.H3 L 249 G.H3.08
Ionic ICL3 K 219 - G.H5 D 341 G.H5.13
Polar ICL3 K 219 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 219 - G.H5 D 341 G.H5.13
Van-der-waals ICL2 V 129 34x51 G.s2s3 K 192 G.s2s3.01
Ionic TM4 K 138 4x40 G.HN E 28 G.HN.52
Polar TM4 K 138 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 K 138 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 K 138 4x40 G.HN E 28 G.HN.52
Hydrophobic C-term C 335 - G.H3 K 248 G.H3.07
Polar C-term C 335 - G.H2 R 208 G.H2.04
Hydrophobic C-term C 335 - G.H2 R 208 G.H2.04
Van-der-waals C-term C 335 - G.H2 R 208 G.H2.04