G12 - CysLT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 M 140 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 375 G.H5.20
Polar C-term V 333 - G.H3 K 284 G.H3.16
Van-der-waals C-term V 333 - G.H3 K 284 G.H3.16
Hydrophobic TM6 K 244 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 244 6x33 G.H5 M 379 G.H5.24
Ionic ICL1 K 69 - G.H5 E 373 G.H5.18
Polar H8 E 310 8x48 G.H5 M 379 G.H5.24
Polar H8 N 311 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 311 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 311 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 146 34x53 G.H5 I 378 G.H5.23
Hydrophobic C-term W 339 - G.H3 E 278 G.H3.10
Hydrophobic TM5 V 231 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 S 241 6x30 G.H5 L 375 G.H5.20
Polar TM3 A 139 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 374 G.H5.19
Aromatic ICL2 F 144 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 144 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 144 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 A 245 6x34 G.H5 L 375 G.H5.20
Hydrophobic H8 G 309 8x47 G.H5 L 380 G.H5.25
Ionic C-term E 343 - G.H2 R 232 G.H2.01
Hydrophobic ICL2 F 144 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 144 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 147 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 M 140 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 M 140 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 144 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 144 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM2 V 73 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 147 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 238 6x27 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 144 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM7 A 308 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 A 308 7x56 G.H5 M 379 G.H5.24
Polar ICL2 H 148 34x55 G.hns1 R 56 G.hns1.03
Aromatic ICL2 H 148 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 148 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 148 34x55 G.hns1 R 56 G.hns1.03
Polar ICL3 E 235 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM2 N 74 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 139 3x53 G.H5 L 371 G.H5.16
Ionic ICL3 E 235 - G.h4s6 R 339 G.h4s6.08
Polar ICL3 E 235 - G.h4s6 R 339 G.h4s6.08
Hydrophobic ICL2 H 148 34x55 G.S3 P 222 G.S3.02
Hydrophobic C-term F 334 - G.H3 L 285 G.H3.17
Hydrophobic TM3 A 139 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 I 378 G.H5.23
Polar ICL2 T 150 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 T 150 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 143 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 143 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 A 245 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 245 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM2 M 77 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 144 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 144 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 146 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 L 146 34x53 G.H5 N 374 G.H5.19
Polar ICL2 P 143 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 143 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 S 241 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 241 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 244 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM6 L 238 6x27 G.H5 Q 372 G.H5.17
Van-der-waals TM6 L 238 6x27 G.H5 Q 372 G.H5.17
Polar H8 E 310 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 310 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 310 8x48 G.H5 Q 381 G.H5.26
Polar H8 N 311 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 311 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 311 8x49 G.H5 L 380 G.H5.25
Hydrophobic C-term L 340 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 340 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 F 144 34x51 G.H5 V 366 G.H5.11
Polar TM3 R 136 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 143 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 143 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 143 34x50 G.H5 K 367 G.H5.12
Polar ICL2 H 148 34x55 G.s2s3 K 220 G.s2s3.02
Polar H8 E 310 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 E 310 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 E 310 8x48 G.H5 L 380 G.H5.25