Gq -
CysLT2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | T | 71 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | T | 71 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | H | 242 | 6x31 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | L | 340 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | L | 340 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | W | 339 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | W | 339 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL2 | L | 146 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | L | 146 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | I | 249 | 6x38 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | F | 334 | - | G.H3 | P | 262 | G.H3.16 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | F | 144 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | C-term | W | 339 | - | G.H3 | Y | 261 | G.H3.15 |
Aromatic | C-term | W | 339 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | W | 339 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | W | 339 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | ICL3 | E | 235 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | E | 235 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | TM6 | A | 245 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 245 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 245 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | E | 343 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | E | 343 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM6 | A | 245 | 6x34 | G.H5 | V | 359 | G.H5.26 |
Polar | TM6 | S | 241 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | S | 241 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | K | 244 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Polar | H8 | N | 311 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | H8 | N | 311 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM3 | V | 135 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | V | 135 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | C-term | F | 334 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 334 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | W | 339 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | W | 339 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM3 | A | 139 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 139 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM7 | A | 308 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | A | 308 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | V | 227 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM6 | L | 238 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | L | 238 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Polar | TM3 | R | 136 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | R | 136 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | V | 73 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | V | 73 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Polar | TM7 | A | 308 | 7x56 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM7 | A | 308 | 7x56 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM7 | A | 308 | 7x56 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | L | 238 | 6x27 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | L | 238 | 6x27 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 143 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | H8 | G | 309 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Aromatic | ICL2 | F | 144 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | F | 144 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | F | 144 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | M | 140 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | L | 147 | 34x54 | G.S1 | L | 40 | G.S1.02 |
Ionic | C-term | E | 343 | - | G.H2 | R | 213 | G.H2.04 |
Polar | C-term | E | 343 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | E | 343 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | E | 343 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM6 | A | 245 | 6x34 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | A | 245 | 6x34 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | M | 140 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | W | 339 | - | G.H2 | W | 216 | G.H2.07 |
Polar | TM6 | T | 248 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 248 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 248 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | C-term | V | 336 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | V | 336 | - | G.H2 | I | 217 | G.H2.08 |
Polar | H8 | E | 310 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | E | 310 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | E | 310 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL3 | E | 235 | - | G.S6 | I | 324 | G.S6.01 |
Polar | TM7 | A | 308 | 7x56 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM7 | A | 308 | 7x56 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | V | 346 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | ICL2 | F | 144 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | TM5 | L | 228 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Polar | TM3 | A | 139 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 139 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 139 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | L | 238 | 6x27 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | L | 238 | 6x27 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | H | 242 | 6x31 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | H | 242 | 6x31 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | H | 242 | 6x31 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL2 | H | 148 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Aromatic | ICL2 | H | 148 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | H | 148 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | H | 148 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM6 | S | 241 | 6x30 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | S | 241 | 6x30 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM2 | M | 77 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | M | 77 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | W | 339 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | W | 339 | - | G.H2 | R | 213 | G.H2.04 |
Polar | C-term | E | 343 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | ICL2 | P | 143 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 143 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM6 | H | 242 | 6x31 | G.H5 | L | 353 | G.H5.20 |