Gs -
CB1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | A | 301 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM2 | R | 150 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL2 | L | 222 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 222 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Polar | TM6 | L | 341 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | L | 341 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 341 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | Q | 314 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 222 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM6 | M | 337 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | M | 337 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | L | 341 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Ionic | C-term | D | 430 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | D | 430 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | D | 430 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | D | 430 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL3 | Q | 314 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Aromatic | TM3 | R | 214 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 214 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | T | 313 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Polar | TM3 | D | 213 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 213 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 221 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 221 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | T | 313 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | T | 313 | - | G.S6 | C | 359 | G.S6.01 |
Polar | TM6 | T | 344 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 344 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | I | 218 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 218 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 218 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM3 | I | 218 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | H8 | K | 402 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | K | 402 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 221 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Aromatic | ICL2 | Y | 224 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 224 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Y | 224 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Ionic | C-term | D | 423 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | D | 423 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | D | 423 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | D | 423 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM3 | S | 217 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | S | 217 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM6 | Q | 334 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | Q | 334 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | Q | 334 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | M | 308 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | M | 308 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Ionic | TM5 | H | 304 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | H | 304 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | H | 304 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 304 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | ICL1 | C | 149 | - | G.hns1 | R | 38 | G.hns1.02 |
Ionic | ICL3 | K | 315 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | K | 315 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | K | 315 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | K | 315 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL2 | K | 225 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | K | 225 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | K | 455 | - | G.s4h3 | Q | 262 | G.s4h3.13 |
Van-der-waals | C-term | K | 455 | - | G.s4h3 | Q | 262 | G.s4h3.13 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 222 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM6 | L | 341 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | K | 315 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | I | 297 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM3 | I | 218 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 218 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | R | 311 | 5x75 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM5 | R | 311 | 5x75 | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL3 | I | 317 | - | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | ICL3 | T | 313 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | TM7 | R | 400 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | R | 400 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | R | 226 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | C-term | G | 427 | - | G.H3 | R | 280 | G.H3.16 |
Polar | ICL3 | R | 331 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | R | 331 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | R | 331 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Polar | C-term | K | 455 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Hydrophobic | C-term | K | 455 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Van-der-waals | C-term | K | 455 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Hydrophobic | TM2 | S | 152 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | R | 226 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 226 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | TM6 | L | 345 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 345 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | P | 221 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | Y | 224 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Ionic | H8 | R | 405 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | R | 405 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 405 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 405 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 402 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | H8 | K | 402 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Ionic | TM5 | R | 307 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | R | 307 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | R | 307 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | C-term | S | 429 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ICL2 | P | 221 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 221 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM5 | H | 304 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | H | 304 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Ionic | H8 | K | 402 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 402 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | K | 402 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 402 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | I | 317 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | I | 317 | - | G.H4 | D | 343 | G.H4.13 |
Polar | H8 | S | 401 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 401 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 401 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | M | 308 | 5x72 | G.S6 | Y | 360 | G.S6.02 |
Polar | H8 | D | 403 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM5 | R | 311 | 5x75 | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | TM5 | R | 311 | 5x75 | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | TM6 | T | 344 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 344 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | T | 313 | - | G.S6 | P | 361 | G.S6.03 |
Ionic | TM5 | R | 311 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Polar | TM5 | R | 311 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | TM5 | R | 311 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM5 | R | 311 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | ICL3 | I | 317 | - | G.H4 | L | 346 | G.H4.16 |
Polar | ICL3 | R | 331 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Polar | TM3 | S | 217 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | S | 217 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | S | 217 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | I | 297 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | Q | 334 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | Q | 334 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 334 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Ionic | C-term | D | 428 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | C-term | D | 428 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | D | 428 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | ICL3 | R | 331 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 331 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Polar | C-term | D | 428 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | D | 428 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | D | 428 | - | G.H3 | R | 280 | G.H3.16 |