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CB2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 139 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | Y | 141 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | Y | 141 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | Y | 141 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | H | 226 | - | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | TM6 | L | 239 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | K | 67 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | K | 67 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Polar | ICL3 | R | 236 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | C-term | W | 349 | - | G.s4h3 | T | 240 | G.s4h3.13 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | L | 223 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | H8 | S | 303 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | S | 303 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | C | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | C | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | C | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | M | 234 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | M | 234 | - | G.H4 | E | 309 | G.H4.16 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.H5 | A | 338 | G.H5.10 |
Polar | ICL3 | R | 236 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | R | 236 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | TM6 | L | 239 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | L | 135 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM2 | Y | 70 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | H | 219 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | W | 349 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Van-der-waals | C-term | W | 349 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Polar | ICL2 | P | 138 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Y | 141 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Y | 141 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | T | 246 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 246 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 246 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | H | 219 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM6 | L | 239 | 6x29 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | L | 239 | 6x29 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL3 | R | 236 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | ICL2 | P | 139 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | P | 139 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL3 | R | 229 | - | G.H4 | E | 298 | G.H4.04 |
Polar | C-term | C | 360 | - | H.HB | K | 105 | H.HB.07 |
Hydrophobic | C-term | C | 360 | - | H.HB | K | 105 | H.HB.07 |
Van-der-waals | C-term | C | 360 | - | H.HB | K | 105 | H.HB.07 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | Y | 70 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | L | 243 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM2 | Y | 70 | 2x40 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | Y | 70 | 2x40 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM2 | S | 69 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | S | 69 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | S | 69 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Polar | TM3 | C | 134 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | C | 134 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | C | 134 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | L | 243 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | H | 226 | - | G.S6 | H | 322 | G.S6.04 |
Ionic | TM6 | R | 242 | 6x32 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | C-term | E | 341 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Polar | C-term | E | 341 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Polar | TM6 | R | 242 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Aromatic | TM6 | R | 242 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 242 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 242 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Ionic | TM5 | H | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Ionic | ICL3 | H | 226 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | H | 226 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | H | 226 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | H | 226 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | R | 236 | - | G.H5 | Y | 354 | G.H5.26 |
Polar | TM2 | S | 69 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Ionic | ICL3 | R | 229 | - | G.H4 | D | 299 | G.H4.05 |
Polar | ICL3 | R | 229 | - | G.H4 | D | 299 | G.H4.05 |
Van-der-waals | ICL3 | R | 229 | - | G.H4 | D | 299 | G.H4.05 |
Hydrophobic | TM6 | L | 247 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | H | 226 | - | G.H5 | V | 334 | G.H5.06 |
Van-der-waals | ICL3 | H | 226 | - | G.H5 | V | 334 | G.H5.06 |
Ionic | ICL3 | R | 236 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | R | 236 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | E | 318 | G.h4s6.12 |