G15 - CRF1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 G 249 4x63 G.H5 V 363 G.H5.15
Hydrophobic TM4 W 246 4x60 G.H5 L 368 G.H5.20
Van-der-waals TM4 W 246 4x60 G.H5 L 368 G.H5.20
Polar TM2 A 167 2x62 G.h2s4 N 225 G.h2s4.03
Van-der-waals TM2 A 167 2x62 G.h2s4 N 225 G.h2s4.03
Hydrophobic TM2 V 172 2x67 G.hns1 R 40 G.hns1.02
Van-der-waals TM2 V 172 2x67 G.hns1 R 40 G.hns1.02
Hydrophobic ECL1 V 180 - G.H5 I 371 G.H5.23
Van-der-waals ECL1 V 180 - G.H5 I 371 G.H5.23
Polar ECL1 V 180 - G.H5 E 370 G.H5.22
Van-der-waals ECL1 V 180 - G.H5 E 370 G.H5.22
Hydrophobic TM2 I 159 2x54 G.HN A 21 G.HN.36
Van-der-waals TM2 I 159 2x54 G.HN A 21 G.HN.36
Hydrophobic TM4 W 246 4x60 G.H5 L 364 G.H5.16
Polar TM2 A 161 2x56 G.HN R 3 G.HN.03
Hydrophobic TM2 A 161 2x56 G.HN R 3 G.HN.03
Van-der-waals TM2 A 161 2x56 G.HN R 3 G.HN.03
Hydrophobic TM2 I 159 2x54 G.HN A 22 G.HN.37
Van-der-waals TM2 I 159 2x54 G.HN A 22 G.HN.37
Polar TM2 S 160 2x55 G.HN S 4 G.HN.04
Hydrophobic TM4 P 241 4x55 G.H5 Y 367 G.H5.19
Van-der-waals TM4 P 241 4x55 G.H5 Y 367 G.H5.19
Hydrophobic TM2 T 168 2x63 G.h2s4 N 225 G.h2s4.03
Van-der-waals TM2 T 168 2x63 G.h2s4 N 225 G.h2s4.03
Hydrophobic TM6 L 323 6x49 G.H5 L 368 G.H5.20
Van-der-waals TM6 L 323 6x49 G.H5 L 368 G.H5.20
Polar TM2 W 169 2x64 G.h2s4 N 225 G.h2s4.03
Hydrophobic TM2 W 169 2x64 G.h2s4 N 225 G.h2s4.03
Van-der-waals TM2 W 169 2x64 G.h2s4 N 225 G.h2s4.03
Hydrophobic ECL1 M 176 - G.H5 Y 367 G.H5.19
Van-der-waals ECL1 M 176 - G.H5 Y 367 G.H5.19
Polar TM7 V 343 7x36 G.H5 N 372 G.H5.24
Hydrophobic TM2 T 175 2x70 G.hns1 R 40 G.hns1.02
Van-der-waals TM2 T 175 2x70 G.hns1 R 40 G.hns1.02
Polar TM2 I 159 2x54 G.HN D 25 G.HN.40
Hydrophobic TM2 I 159 2x54 G.HN D 25 G.HN.40
Van-der-waals TM2 I 159 2x54 G.HN D 25 G.HN.40
Hydrophobic TM4 W 246 4x60 G.H5 Y 367 G.H5.19
Hydrophobic TM4 K 250 4x64 G.S3 T 202 G.S3.01
Van-der-waals TM4 K 250 4x64 G.S3 T 202 G.S3.01
Polar TM2 V 171 2x66 G.hns1 R 40 G.hns1.02
Hydrophobic TM2 V 171 2x66 G.hns1 R 40 G.hns1.02
Van-der-waals TM2 V 171 2x66 G.hns1 R 40 G.hns1.02
Hydrophobic TM2 I 153 2x48 G.HN L 33 G.HN.48
Van-der-waals TM2 I 153 2x48 G.HN L 33 G.HN.48
Hydrophobic TM2 F 162 2x57 G.HN R 3 G.HN.03
Van-der-waals TM2 F 162 2x57 G.HN R 3 G.HN.03
Hydrophobic TM4 G 249 4x63 G.H5 L 364 G.H5.16
Ionic ECL1 S 177 - G.H5 E 370 G.H5.22
Polar ECL1 S 177 - G.H5 E 370 G.H5.22
Hydrophobic ECL1 S 177 - G.H5 E 370 G.H5.22
Van-der-waals ECL1 S 177 - G.H5 E 370 G.H5.22
Hydrophobic TM4 I 242 4x56 G.H5 Y 367 G.H5.19
Polar C-term I 397 - G.H5 N 372 G.H5.24
Hydrophobic C-term I 397 - G.H5 N 372 G.H5.24
Van-der-waals C-term I 397 - G.H5 N 372 G.H5.24
Hydrophobic TM2 L 158 2x53 G.HN W 7 G.HN.07
Van-der-waals TM2 L 158 2x53 G.HN W 7 G.HN.07
Hydrophobic TM6 L 322 6x48 G.H5 L 364 G.H5.16
Hydrophobic TM6 T 326 6x52 G.H5 L 364 G.H5.16
Hydrophobic C-term S 396 - G.H5 N 372 G.H5.24
Van-der-waals C-term S 396 - G.H5 N 372 G.H5.24
Polar TM2 I 159 2x54 G.HN T 6 G.HN.06
Hydrophobic TM2 I 159 2x54 G.HN T 6 G.HN.06
Hydrophobic TM2 I 159 2x54 G.HN R 3 G.HN.03
Polar TM4 K 250 4x64 G.H5 R 360 G.H5.12
Hydrophobic TM4 K 250 4x64 G.H5 R 360 G.H5.12
Van-der-waals TM4 K 250 4x64 G.H5 R 360 G.H5.12
Hydrophobic TM4 A 245 4x59 G.H5 Y 367 G.H5.19
Van-der-waals TM4 A 245 4x59 G.H5 Y 367 G.H5.19
Ionic TM2 Q 173 2x68 G.H5 E 370 G.H5.22
Polar TM2 Q 173 2x68 G.H5 E 370 G.H5.22
Hydrophobic TM2 Q 173 2x68 G.H5 E 370 G.H5.22
Van-der-waals TM2 Q 173 2x68 G.H5 E 370 G.H5.22
Hydrophobic TM2 A 161 2x56 G.HN A 2 G.HN.02
Hydrophobic TM6 Y 327 6x53 G.H5 L 374 G.H5.26
Polar TM2 S 160 2x55 G.HN R 3 G.HN.03
Hydrophobic TM2 S 160 2x55 G.HN R 3 G.HN.03
Van-der-waals TM2 S 160 2x55 G.HN R 3 G.HN.03
Polar C-term M 395 - G.H5 N 372 G.H5.24
Van-der-waals C-term M 395 - G.H5 N 372 G.H5.24
Polar TM6 T 326 6x52 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM7 S 340 7x33 G.H5 L 374 G.H5.26
Hydrophobic TM4 I 242 4x56 G.H5 I 371 G.H5.23
Van-der-waals TM4 I 242 4x56 G.H5 I 371 G.H5.23
Hydrophobic TM4 K 250 4x64 G.S1 L 43 G.S1.02
Van-der-waals TM4 K 250 4x64 G.S1 L 43 G.S1.02
Hydrophobic TM7 N 348 7x41 G.H5 L 373 G.H5.25
Hydrophobic TM4 G 249 4x63 G.H5 R 360 G.H5.12
Van-der-waals TM4 G 249 4x63 G.H5 R 360 G.H5.12
Polar TM2 N 157 2x52 G.HN Q 26 G.HN.41
Hydrophobic TM2 N 157 2x52 G.HN Q 26 G.HN.41
Van-der-waals TM2 N 157 2x52 G.HN Q 26 G.HN.41
Polar TM2 V 171 2x66 G.HN K 36 G.HN.51
Hydrophobic TM2 V 171 2x66 G.HN K 36 G.HN.51
Van-der-waals TM2 V 171 2x66 G.HN K 36 G.HN.51
Hydrophobic TM7 F 344 7x37 G.H5 L 373 G.H5.25
Van-der-waals TM7 F 344 7x37 G.H5 L 373 G.H5.25
Hydrophobic TM2 Q 173 2x68 G.H5 R 366 G.H5.18
Van-der-waals TM2 Q 173 2x68 G.H5 R 366 G.H5.18
Ionic TM6 T 326 6x52 G.H5 D 361 G.H5.13
Polar TM6 T 326 6x52 G.H5 D 361 G.H5.13
Hydrophobic TM6 T 326 6x52 G.H5 D 361 G.H5.13
Van-der-waals TM6 T 326 6x52 G.H5 D 361 G.H5.13
Polar TM4 K 250 4x64 G.H5 F 356 G.H5.08
Aromatic TM4 K 250 4x64 G.H5 F 356 G.H5.08
Hydrophobic TM4 K 250 4x64 G.H5 F 356 G.H5.08
Van-der-waals TM4 K 250 4x64 G.H5 F 356 G.H5.08
Hydrophobic TM2 R 165 2x60 G.HN L 32 G.HN.47