Gs - CRF1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 N 157 2x52 G.H3 W 281 G.H3.17
Van-der-waals TM2 N 157 2x52 G.H3 W 281 G.H3.17
Hydrophobic TM6 T 326 6x52 G.H5 L 388 G.H5.20
Polar TM2 R 151 2x46 G.h2s4 V 241 G.h2s4.04
Hydrophobic TM2 R 151 2x46 G.h2s4 V 241 G.h2s4.04
Van-der-waals TM2 R 151 2x46 G.h2s4 V 241 G.h2s4.04
Polar TM2 I 154 2x49 G.H3 W 281 G.H3.17
Hydrophobic TM2 I 154 2x49 G.H3 W 281 G.H3.17
Van-der-waals TM2 I 154 2x49 G.H3 W 281 G.H3.17
Hydrophobic ECL1 M 176 - G.HN K 34 G.HN.51
Van-der-waals ECL1 M 176 - G.HN K 34 G.HN.51
Hydrophobic TM4 W 246 4x60 G.H5 L 388 G.H5.20
Van-der-waals TM4 W 246 4x60 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 323 6x49 G.H5 L 393 G.H5.25
Van-der-waals TM2 R 151 2x46 G.h2s4 F 238 G.h2s4.01
Polar TM4 W 246 4x60 G.H5 Q 384 G.H5.16
Hydrophobic TM4 W 246 4x60 G.H5 Q 384 G.H5.16
Van-der-waals TM4 W 246 4x60 G.H5 Q 384 G.H5.16
Hydrophobic TM2 L 158 2x53 G.H3 W 281 G.H3.17
Ionic TM6 T 326 6x52 G.H5 D 381 G.H5.13
Polar TM6 T 326 6x52 G.H5 D 381 G.H5.13
Hydrophobic TM6 T 326 6x52 G.H5 D 381 G.H5.13
Van-der-waals TM6 T 326 6x52 G.H5 D 381 G.H5.13
Hydrophobic TM4 K 250 4x64 G.H5 I 383 G.H5.15
Polar TM4 K 250 4x64 G.H5 R 380 G.H5.12
Hydrophobic TM4 K 250 4x64 G.H5 R 380 G.H5.12
Van-der-waals TM4 K 250 4x64 G.H5 R 380 G.H5.12
Hydrophobic TM6 L 323 6x49 G.H5 L 388 G.H5.20
Hydrophobic C-term S 396 - G.H5 E 392 G.H5.24
Hydrophobic H8 A 392 8x72 G.H5 Y 391 G.H5.23
Polar TM6 T 326 6x52 G.H5 Q 384 G.H5.16
Hydrophobic TM6 T 326 6x52 G.H5 Q 384 G.H5.16
Van-der-waals TM6 T 326 6x52 G.H5 Q 384 G.H5.16
Van-der-waals TM7 S 340 7x33 G.H5 L 394 G.H5.26
Aromatic ECL1 V 180 - G.H5 Y 391 G.H5.23
Hydrophobic ECL1 V 180 - G.H5 Y 391 G.H5.23
Van-der-waals ECL1 V 180 - G.H5 Y 391 G.H5.23
Hydrophobic TM2 I 159 2x54 G.H2 I 235 G.H2.08
Hydrophobic TM2 R 151 2x46 G.h3s5 T 284 G.h3s5.02
Van-der-waals TM2 R 151 2x46 G.h3s5 T 284 G.h3s5.02
Hydrophobic TM4 G 249 4x63 G.H5 I 383 G.H5.15
Van-der-waals TM4 G 249 4x63 G.H5 I 383 G.H5.15
Hydrophobic TM6 Y 327 6x53 G.H5 L 394 G.H5.26
Hydrophobic TM7 L 351 7x44 G.H5 Y 391 G.H5.23
Hydrophobic ECL1 N 184 - G.H5 Y 391 G.H5.23
Van-der-waals ECL1 N 184 - G.H5 Y 391 G.H5.23
Polar TM6 T 326 6x52 G.H5 R 385 G.H5.17
Hydrophobic TM6 T 326 6x52 G.H5 R 385 G.H5.17
Hydrophobic TM2 R 151 2x46 G.h2s4 D 240 G.h2s4.03
Polar TM4 G 249 4x63 G.H5 Q 384 G.H5.16
Hydrophobic TM4 G 249 4x63 G.H5 Q 384 G.H5.16
Van-der-waals TM4 G 249 4x63 G.H5 Q 384 G.H5.16
Polar ICL1 R 148 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 R 148 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 148 12x51 G.hns1 R 38 G.hns1.02
Polar TM4 K 250 4x64 G.H5 F 376 G.H5.08
Aromatic TM4 K 250 4x64 G.H5 F 376 G.H5.08
Hydrophobic TM4 K 250 4x64 G.H5 F 376 G.H5.08
Van-der-waals TM4 K 250 4x64 G.H5 F 376 G.H5.08
Hydrophobic TM4 K 250 4x64 G.H5 C 379 G.H5.11
Van-der-waals TM4 K 250 4x64 G.H5 C 379 G.H5.11
Hydrophobic TM7 N 348 7x41 G.H5 L 393 G.H5.25
Hydrophobic ECL1 M 176 - G.hns1 R 38 G.hns1.02
Van-der-waals ECL1 M 176 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 L 322 6x48 G.H5 Q 384 G.H5.16
Polar TM2 N 157 2x52 G.H3 R 280 G.H3.16
Hydrophobic TM4 P 241 4x55 G.H5 Y 391 G.H5.23
Van-der-waals TM4 P 241 4x55 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 151 2x46 G.h3s5 I 285 G.h3s5.03
Van-der-waals TM2 R 151 2x46 G.h3s5 I 285 G.h3s5.03
Hydrophobic TM4 A 245 4x59 G.H5 H 387 G.H5.19
Hydrophobic TM4 K 250 4x64 G.S3 F 219 G.S3.03
Hydrophobic TM4 G 249 4x63 G.H5 R 380 G.H5.12
Aromatic TM4 K 250 4x64 G.S1 H 41 G.S1.02
Hydrophobic TM4 K 250 4x64 G.S1 H 41 G.S1.02
Van-der-waals TM4 K 250 4x64 G.S1 H 41 G.S1.02
Hydrophobic TM2 R 151 2x46 G.H3 L 282 G.H3.18
Polar ECL2 E 256 - G.HN Q 35 G.HN.52
Hydrophobic ECL2 E 256 - G.HN Q 35 G.HN.52
Van-der-waals ECL2 E 256 - G.HN Q 35 G.HN.52
Hydrophobic TM4 I 242 4x56 G.H5 Y 391 G.H5.23
Van-der-waals TM4 I 242 4x56 G.H5 Y 391 G.H5.23
Polar TM6 F 330 6x56 G.H5 R 385 G.H5.17
Hydrophobic TM6 F 330 6x56 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 323 6x49 G.H5 L 394 G.H5.26
Polar C-term I 397 - G.H5 E 392 G.H5.24
Hydrophobic C-term I 397 - G.H5 E 392 G.H5.24
Van-der-waals C-term I 397 - G.H5 E 392 G.H5.24
Polar TM4 V 238 4x52 G.H5 Y 391 G.H5.23
Van-der-waals TM4 V 238 4x52 G.H5 Y 391 G.H5.23
Hydrophobic TM4 Y 253 4x67 G.hns1 A 39 G.hns1.03
Van-der-waals TM4 Y 253 4x67 G.hns1 A 39 G.hns1.03
Hydrophobic TM4 K 250 4x64 G.S3 V 217 G.S3.01
Van-der-waals TM4 K 250 4x64 G.S3 V 217 G.S3.01
Hydrophobic TM7 F 344 7x37 G.H5 L 393 G.H5.25
Ionic TM2 I 153 2x48 G.h4s6 R 356 G.h4s6.12
Polar ECL1 V 180 - G.H5 Q 390 G.H5.22
Hydrophobic ECL1 V 180 - G.H5 Q 390 G.H5.22
Van-der-waals ECL1 V 180 - G.H5 Q 390 G.H5.22