Gs -
CRF1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 14.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | I | 159 | 2x54 | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM2 | R | 151 | 2x46 | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | C-term | S | 396 | - | G.H5 | E | 392 | G.H5.24 |
Ionic | TM2 | I | 153 | 2x48 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | L | 323 | 6x49 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ECL1 | N | 184 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ECL1 | N | 184 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | L | 323 | 6x49 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.H5 | I | 383 | G.H5.15 |
Aromatic | ECL1 | V | 180 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ECL1 | V | 180 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ECL1 | V | 180 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | TM4 | K | 250 | 4x64 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | TM6 | L | 323 | 6x49 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | TM4 | K | 250 | 4x64 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ECL1 | M | 176 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ECL1 | M | 176 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | I | 397 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | I | 397 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | I | 397 | - | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | T | 326 | 6x52 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | T | 326 | 6x52 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM6 | T | 326 | 6x52 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM4 | V | 238 | 4x52 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM4 | V | 238 | 4x52 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM7 | L | 351 | 7x44 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | R | 151 | 2x46 | G.h3s5 | I | 285 | G.h3s5.03 |
Van-der-waals | TM2 | R | 151 | 2x46 | G.h3s5 | I | 285 | G.h3s5.03 |
Polar | TM4 | G | 249 | 4x63 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM4 | G | 249 | 4x63 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM4 | G | 249 | 4x63 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM4 | Y | 253 | 4x67 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | TM4 | Y | 253 | 4x67 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM7 | F | 344 | 7x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM7 | N | 348 | 7x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | R | 151 | 2x46 | G.H3 | L | 282 | G.H3.18 |
Polar | ICL1 | R | 148 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | R | 148 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 148 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ECL1 | V | 180 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ECL1 | V | 180 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ECL1 | V | 180 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | TM2 | I | 154 | 2x49 | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM2 | I | 154 | 2x49 | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | TM2 | I | 154 | 2x49 | G.H3 | W | 281 | G.H3.17 |
Polar | TM4 | K | 250 | 4x64 | G.H5 | F | 376 | G.H5.08 |
Aromatic | TM4 | K | 250 | 4x64 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | TM4 | K | 250 | 4x64 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | TM7 | S | 340 | 7x33 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | R | 151 | 2x46 | G.h2s4 | F | 238 | G.h2s4.01 |
Polar | TM4 | K | 250 | 4x64 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM4 | K | 250 | 4x64 | G.H5 | R | 380 | G.H5.12 |
Polar | TM6 | T | 326 | 6x52 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | T | 326 | 6x52 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | T | 326 | 6x52 | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | F | 330 | 6x56 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | F | 330 | 6x56 | G.H5 | R | 385 | G.H5.17 |
Aromatic | TM4 | K | 250 | 4x64 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | TM4 | K | 250 | 4x64 | G.S1 | H | 41 | G.S1.02 |
Polar | TM4 | W | 246 | 4x60 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM4 | W | 246 | 4x60 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM4 | W | 246 | 4x60 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM4 | W | 246 | 4x60 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM4 | W | 246 | 4x60 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | L | 322 | 6x48 | G.H5 | Q | 384 | G.H5.16 |
Polar | ECL2 | E | 256 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ECL2 | E | 256 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ECL2 | E | 256 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | P | 241 | 4x55 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM4 | P | 241 | 4x55 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM4 | A | 245 | 4x59 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM4 | G | 249 | 4x63 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | H8 | A | 392 | 8x72 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ECL1 | M | 176 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | ECL1 | M | 176 | - | G.HN | K | 34 | G.HN.51 |
Polar | TM2 | R | 151 | 2x46 | G.h2s4 | V | 241 | G.h2s4.04 |
Hydrophobic | TM2 | R | 151 | 2x46 | G.h2s4 | V | 241 | G.h2s4.04 |
Van-der-waals | TM2 | R | 151 | 2x46 | G.h2s4 | V | 241 | G.h2s4.04 |
Hydrophobic | TM2 | R | 151 | 2x46 | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | TM2 | R | 151 | 2x46 | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | TM4 | I | 242 | 4x56 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM4 | I | 242 | 4x56 | G.H5 | Y | 391 | G.H5.23 |
Ionic | TM6 | T | 326 | 6x52 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | T | 326 | 6x52 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | T | 326 | 6x52 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | T | 326 | 6x52 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM2 | L | 158 | 2x53 | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM6 | Y | 327 | 6x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | N | 157 | 2x52 | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | TM2 | N | 157 | 2x52 | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM4 | K | 250 | 4x64 | G.S3 | F | 219 | G.S3.03 |
Hydrophobic | TM4 | G | 249 | 4x63 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | TM4 | G | 249 | 4x63 | G.H5 | I | 383 | G.H5.15 |
Polar | TM2 | N | 157 | 2x52 | G.H3 | R | 280 | G.H3.16 |