G14 - CXCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 238 5x65 G.H5 L 345 G.H5.16
Hydrophobic TM3 R 144 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM5 T 237 5x64 G.H5 L 345 G.H5.16
Hydrophobic ICL3 M 243 - G.H5 T 343 G.H5.14
Polar C-term L 360 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 360 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 360 - G.H2 R 209 G.H2.04
Hydrophobic ICL2 A 151 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 I 253 6x37 G.H5 L 354 G.H5.25
Polar ICL3 H 242 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 H 242 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 H 242 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 M 243 - G.h4s6 V 319 G.h4s6.20
Polar ICL3 H 242 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 H 242 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 M 243 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 M 243 - G.H5 Q 346 G.H5.17
Hydrophobic H8 G 318 8x47 G.H5 V 355 G.H5.26
Van-der-waals H8 G 318 8x47 G.H5 V 355 G.H5.26
Polar H8 F 321 8x50 G.H5 N 353 G.H5.24
Hydrophobic H8 F 321 8x50 G.H5 N 353 G.H5.24
Hydrophobic C-term L 360 - G.H3 L 250 G.H3.08
Van-der-waals C-term L 360 - G.H3 L 250 G.H3.08
Hydrophobic TM2 T 83 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 T 83 2x39 G.H5 F 352 G.H5.23
Polar TM3 R 144 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 F 352 G.H5.23
Hydrophobic ICL2 T 152 34x51 G.H5 I 344 G.H5.15
Hydrophobic H8 G 318 8x47 G.H5 N 353 G.H5.24
Polar TM6 Q 245 6x29 G.H5 Q 346 G.H5.17
Polar H8 K 320 8x49 G.H5 E 351 G.H5.22
Hydrophobic H8 K 320 8x49 G.H5 E 351 G.H5.22
Hydrophobic TM6 A 249 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 249 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 T 152 34x51 G.S3 I 195 G.S3.01
Van-der-waals ICL2 T 152 34x51 G.S3 I 195 G.S3.01
Polar TM3 A 147 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 S 81 2x37 G.H5 E 351 G.H5.22
Hydrophobic C-term S 344 - G.h3s5 L 261 G.h3s5.01
Van-der-waals C-term S 344 - G.h3s5 L 261 G.h3s5.01
Polar ICL2 A 151 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM3 D 143 3x49 G.H5 F 352 G.H5.23
Van-der-waals TM3 D 143 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM3 I 148 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 L 345 G.H5.16
Hydrophobic ICL3 M 243 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 M 243 - G.H5 D 342 G.H5.13
Hydrophobic TM3 I 148 3x54 G.H5 L 349 G.H5.20
Polar TM7 Y 314 7x53 G.H5 N 353 G.H5.24
Hydrophobic TM3 I 148 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 148 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 Q 245 6x29 G.H5 V 355 G.H5.26
Van-der-waals TM6 Q 245 6x29 G.H5 V 355 G.H5.26
Polar ICL2 T 156 34x55 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 T 156 34x55 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 T 156 34x55 G.hns1 R 34 G.hns1.03
Polar TM3 R 144 3x50 G.H5 N 353 G.H5.24
Polar TM6 Q 245 6x29 G.H5 R 350 G.H5.21
Polar H8 Q 319 8x48 G.H5 V 355 G.H5.26
Hydrophobic H8 Q 319 8x48 G.H5 V 355 G.H5.26
Van-der-waals H8 Q 319 8x48 G.H5 V 355 G.H5.26
Polar TM6 A 249 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL3 M 243 - G.H5 L 345 G.H5.16
Van-der-waals ICL3 M 243 - G.H5 L 345 G.H5.16
Ionic ICL2 R 159 34x58 G.H5 E 351 G.H5.22
Hydrophobic TM5 A 241 5x68 G.H5 D 342 G.H5.13
Hydrophobic C-term F 348 - G.H3 W 259 G.H3.17
Van-der-waals C-term F 348 - G.H3 W 259 G.H3.17
Hydrophobic C-term L 360 - G.H3 I 254 G.H3.12
Hydrophobic C-term L 360 - G.H3 T 253 G.H3.11
Van-der-waals C-term L 360 - G.H3 T 253 G.H3.11
Hydrophobic TM3 A 147 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM6 A 249 6x33 G.H5 V 355 G.H5.26
Hydrophobic TM6 V 252 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 248 6x32 G.H5 V 355 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 V 355 G.H5.26
Polar TM6 Q 245 6x29 G.h4s6 E 317 G.h4s6.12
Van-der-waals TM6 Q 245 6x29 G.h4s6 E 317 G.h4s6.12
Polar C-term T 358 - G.H3 Y 257 G.H3.15
Hydrophobic C-term T 358 - G.H3 Y 257 G.H3.15
Van-der-waals C-term T 358 - G.H3 Y 257 G.H3.15
Hydrophobic TM5 L 238 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 155 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 Q 157 34x56 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 Q 157 34x56 G.hns1 R 34 G.hns1.03
Hydrophobic TM5 A 241 5x68 G.H5 L 345 G.H5.16
Van-der-waals TM5 A 241 5x68 G.H5 L 345 G.H5.16
Hydrophobic C-term P 346 - G.H3 P 258 G.H3.16
Hydrophobic C-term P 346 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 T 156 34x55 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 T 156 34x55 G.hns1 R 33 G.hns1.02
Hydrophobic C-term L 360 - G.H2 W 212 G.H2.07