GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | I | 148 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM2 | S | 81 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | Q | 157 | 34x56 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | Q | 157 | 34x56 | G.HN | K | 37 | G.HN.52 |
Polar | TM6 | A | 249 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 249 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | A | 249 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | Q | 319 | 8x48 | G.h4s6 | G | 333 | G.h4s6.15 |
Van-der-waals | H8 | Q | 319 | 8x48 | G.h4s6 | G | 333 | G.h4s6.15 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | V | 252 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 252 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | S | 357 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Polar | H8 | Q | 319 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | H8 | Q | 319 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | Q | 319 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | H8 | G | 318 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | R | 153 | 34x52 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 153 | 34x52 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 153 | 34x52 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | C-term | T | 359 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM5 | A | 241 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | TM6 | R | 248 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | R | 248 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 248 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL3 | G | 244 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | TM7 | Y | 314 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 360 | - | G.H3 | T | 260 | G.H3.11 |
Polar | TM6 | Q | 245 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | Q | 245 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 245 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL3 | M | 243 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | M | 243 | - | G.H5 | D | 361 | G.H5.13 |
Polar | ICL3 | H | 242 | - | G.H5 | K | 357 | G.H5.09 |
Aromatic | ICL3 | H | 242 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | H | 242 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | H | 242 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL2 | Q | 157 | 34x56 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 157 | 34x56 | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | K | 342 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Van-der-waals | C-term | K | 342 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Polar | TM3 | R | 144 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | S | 357 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | S | 357 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | S | 357 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | P | 346 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | P | 346 | - | G.H3 | P | 265 | G.H3.16 |
Polar | C-term | S | 344 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Van-der-waals | C-term | S | 344 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Polar | TM6 | Q | 245 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | Q | 245 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | Q | 245 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL3 | M | 243 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | M | 243 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | L | 360 | - | G.H3 | I | 261 | G.H3.12 |
Van-der-waals | C-term | L | 360 | - | G.H3 | I | 261 | G.H3.12 |
Hydrophobic | TM6 | Q | 245 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | Q | 245 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | A | 249 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | I | 253 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | T | 358 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | C-term | T | 358 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | TM2 | T | 83 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | L | 360 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | ICL3 | M | 243 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL3 | M | 243 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | L | 360 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | L | 360 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | ICL3 | M | 243 | - | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | C-term | P | 346 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | P | 346 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | Q | 319 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | Q | 319 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | Q | 319 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 360 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Van-der-waals | C-term | L | 360 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | F | 348 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | F | 348 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | TM6 | R | 248 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 248 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | H8 | K | 320 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | K | 320 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | G | 318 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | F | 321 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | F | 321 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL3 | H | 242 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | H | 242 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | T | 358 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | ICL3 | M | 243 | - | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | ICL3 | M | 243 | - | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | S | 339 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Aromatic | C-term | F | 348 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | F | 348 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | F | 348 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | L | 368 | G.H5.20 |