G15 -
D1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | L | 231 | 5x75 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM3 | A | 124 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | TM2 | K | 57 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Polar | TM2 | K | 57 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | K | 57 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | E | 376 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | C-term | E | 376 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | E | 376 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Polar | TM6 | T | 273 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | F | 371 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Van-der-waals | C-term | F | 371 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Hydrophobic | C-term | V | 361 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | Y | 131 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | Y | 131 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | TM5 | R | 227 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 227 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 227 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | D | 314 | G.H4.13 |
Van-der-waals | TM5 | A | 238 | 5x82 | G.H4 | D | 314 | G.H4.13 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | V | 361 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM5 | A | 235 | 5x79 | G.h4s6 | T | 321 | G.h4s6.03 |
Hydrophobic | TM5 | A | 221 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | I | 228 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | I | 391 | - | G.HN | I | 31 | G.HN.46 |
Van-der-waals | C-term | I | 391 | - | G.HN | I | 31 | G.HN.46 |
Aromatic | ICL2 | F | 129 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | F | 371 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Van-der-waals | C-term | F | 371 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Ionic | C-term | K | 383 | - | H.HA | E | 74 | H.HA.03 |
Polar | C-term | K | 383 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | K | 383 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | K | 383 | - | H.HA | E | 74 | H.HA.03 |
Polar | TM5 | Q | 242 | 5x86 | G.H4 | R | 318 | G.H4.17 |
Hydrophobic | TM5 | Q | 242 | 5x86 | G.H4 | R | 318 | G.H4.17 |
Van-der-waals | TM5 | Q | 242 | 5x86 | G.H4 | R | 318 | G.H4.17 |
Hydrophobic | C-term | N | 365 | - | G.H2 | K | 217 | G.H2.05 |
Polar | C-term | R | 378 | - | H.HB | P | 121 | H.HB.14 |
Hydrophobic | C-term | G | 379 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Van-der-waals | C-term | G | 379 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Polar | TM7 | F | 333 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Ionic | C-term | E | 359 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Hydrophobic | TM5 | R | 227 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Polar | C-term | R | 378 | - | H.HA | Q | 84 | H.HA.13 |
Hydrophobic | C-term | R | 378 | - | H.HA | Q | 84 | H.HA.13 |
Van-der-waals | C-term | R | 378 | - | H.HA | Q | 84 | H.HA.13 |
Hydrophobic | TM5 | I | 217 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | E | 132 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | E | 132 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | E | 132 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Aromatic | C-term | R | 378 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | C-term | R | 378 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | R | 378 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | TM6 | V | 270 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 270 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | H | 375 | - | G.H2 | S | 214 | G.H2.02 |
Ionic | TM5 | K | 239 | 5x83 | G.h4s6 | D | 325 | G.h4s6.07 |
Hydrophobic | ICL2 | E | 132 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | E | 132 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Ionic | TM5 | E | 232 | 5x76 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM5 | E | 232 | 5x76 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | E | 232 | 5x76 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | I | 220 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | A | 235 | 5x79 | G.H4 | T | 317 | G.H4.16 |