G12 - D2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 T 144 4x34 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 144 4x34 G.hns1 R 56 G.hns1.03
Polar ICL3 R 360 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 R 360 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 R 360 - G.h4s6 R 342 G.h4s6.11
Polar ICL3 R 360 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 R 360 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 R 360 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 M 140 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM2 T 69 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 I 378 G.H5.23
Polar H8 N 430 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 430 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM4 Y 146 4x36 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 Y 146 4x36 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 M 140 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 140 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 F 232 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 F 232 - G.H4 R 329 G.H4.09
Ionic ICL3 R 360 - G.H4 D 336 G.H4.16
Polar ICL3 R 360 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 R 360 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 360 - G.H4 D 336 G.H4.16
Hydrophobic TM3 V 136 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 136 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 R 360 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 R 360 - G.h4s6 R 339 G.h4s6.08
Hydrophobic TM6 M 374 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 374 6x36 G.H5 L 380 G.H5.25
Polar ICL2 P 139 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 139 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 139 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 N 143 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 375 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 139 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 A 371 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 371 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 136 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 136 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 135 3x53 G.H5 L 371 G.H5.16
Ionic TM5 R 219 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 219 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 219 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 219 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 360 - G.h4s6 P 345 G.h4s6.20
Polar TM6 K 367 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 367 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 367 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 426 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 426 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM7 F 429 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 429 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 140 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 Y 142 34x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 140 34x51 G.S3 F 223 G.S3.03
Polar TM3 A 135 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 135 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 R 219 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 219 5x68 G.H5 L 371 G.H5.16
Polar TM3 R 132 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 139 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 139 34x50 G.H5 I 370 G.H5.15
Polar ICL2 N 143 34x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 N 143 34x54 G.H5 N 374 G.H5.19
Van-der-waals ICL2 N 143 34x54 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 135 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 N 430 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 M 140 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM7 I 425 7x52 G.H5 L 380 G.H5.25
Polar TM4 Y 146 4x36 G.HN R 52 G.HN.52
Aromatic TM4 Y 146 4x36 G.HN R 52 G.HN.52
Hydrophobic TM4 Y 146 4x36 G.HN R 52 G.HN.52
Van-der-waals TM4 Y 146 4x36 G.HN R 52 G.HN.52
Van-der-waals TM6 K 367 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 E 368 6x30 G.H5 L 375 G.H5.20
Polar TM5 R 219 5x68 G.H5 K 367 G.H5.12
Polar TM6 E 368 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM5 L 216 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 363 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 L 363 6x25 G.h4s6 S 343 G.h4s6.12
Polar TM6 S 364 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 S 364 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 K 370 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 370 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 139 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 139 34x50 G.H5 K 367 G.H5.12
Polar TM4 R 145 4x35 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 R 145 4x35 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 R 145 4x35 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 R 132 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 132 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 216 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 136 3x54 G.H5 I 378 G.H5.23
Hydrophobic H8 I 431 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 Y 142 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM4 T 144 4x34 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 144 4x34 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 M 140 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 M 140 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 L 216 5x65 G.H5 L 375 G.H5.20