G12 - D3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 323 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM7 T 384 7x54 G.H5 M 379 G.H5.24
Van-der-waals TM7 T 384 7x54 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 136 34x51 G.H5 K 367 G.H5.12
Polar TM6 E 324 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 136 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 215 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM7 F 386 7x56 G.H5 Q 381 G.H5.26
Polar TM3 R 128 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 128 3x50 G.H5 I 378 G.H5.23
Polar ICL2 Q 139 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 Q 139 34x54 G.H5 E 373 G.H5.18
Hydrophobic TM2 V 68 2x43 G.H5 M 379 G.H5.24
Polar ICL3 N 232 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 N 232 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 N 232 - G.H4 R 329 G.H4.09
Van-der-waals ICL1 R 58 12x48 G.HN R 51 G.HN.51
Hydrophobic ICL2 Y 138 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 135 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 135 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 135 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 H 140 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 140 34x55 G.S3 I 221 G.S3.01
Polar TM3 V 133 3x55 G.H5 K 367 G.H5.12
Polar ICL2 P 135 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 135 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 H 140 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 H 140 34x55 G.S3 P 222 G.S3.02
Polar H8 N 387 8x47 G.H5 D 377 G.H5.22
Polar TM3 A 131 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 131 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 131 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 R 222 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 222 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM3 A 131 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 131 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Q 139 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 139 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 R 218 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 L 371 G.H5.16
Polar ICL2 S 145 - G.hns1 R 56 G.hns1.03
Ionic TM5 R 222 5x72 G.H5 D 368 G.H5.13
Polar TM5 R 222 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 222 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 222 5x72 G.H5 D 368 G.H5.13
Hydrophobic ICL2 V 136 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 136 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL3 L 310 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 L 310 - G.H4 Q 333 G.H4.13
Hydrophobic TM6 M 330 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 330 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 132 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 132 3x54 G.H5 L 371 G.H5.16
Polar ICL3 N 232 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 N 232 - G.H4 Q 333 G.H4.13
Polar TM6 R 323 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 323 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 323 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 135 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 135 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 331 6x37 G.H5 L 380 G.H5.25
Polar TM5 R 226 5x76 G.h4s6 R 342 G.h4s6.11
Hydrophobic H8 N 387 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 387 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 G 143 34x58 G.HN R 52 G.HN.52
Hydrophobic TM6 K 326 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 326 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 383 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 383 7x53 G.H5 M 379 G.H5.24
Hydrophobic H8 F 390 8x50 G.H5 M 379 G.H5.24
Van-der-waals H8 F 390 8x50 G.H5 M 379 G.H5.24
Hydrophobic TM5 R 222 5x72 G.h4s6 P 345 G.h4s6.20
Polar ICL2 H 140 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 140 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 140 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 Q 144 - G.HN R 52 G.HN.52
Hydrophobic ICL2 Q 144 - G.HN R 52 G.HN.52
Van-der-waals ICL2 Q 144 - G.HN R 52 G.HN.52
Polar TM6 A 327 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 327 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 327 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 132 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 327 6x33 G.H5 L 375 G.H5.20