G12 - D4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 235 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 P 235 - G.H4 R 329 G.H4.09
Polar ICL2 P 140 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 145 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 R 145 34x55 G.S3 P 222 G.S3.02
Hydrophobic TM5 W 222 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM5 R 226 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 226 5x72 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 R 145 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 145 34x55 G.S3 I 221 G.S3.01
Polar ICL2 G 147 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 K 343 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 K 343 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 343 6x32 G.H5 Q 381 G.H5.26
Polar ICL2 N 144 34x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 N 144 34x54 G.H5 N 374 G.H5.19
Van-der-waals ICL2 N 144 34x54 G.H5 N 374 G.H5.19
Polar H8 N 404 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 N 144 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 N 144 34x54 G.H5 I 370 G.H5.15
Polar ICL2 R 145 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 R 145 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 145 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 R 226 5x72 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 R 226 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 V 137 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 137 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 141 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 141 34x51 G.H5 F 363 G.H5.08
Hydrophobic H8 E 406 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 140 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 230 - G.S6 L 346 G.S6.01
Ionic TM5 R 226 5x72 G.H5 D 368 G.H5.13
Polar TM5 R 226 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 226 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 226 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM6 V 347 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 340 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 R 340 6x29 G.H5 K 376 G.H5.21
Polar ICL3 R 233 - G.S6 H 348 G.S6.03
Aromatic ICL3 R 233 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 R 233 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 R 233 - G.S6 H 348 G.S6.03
Hydrophobic TM5 L 219 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 219 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 137 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 137 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 141 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 W 222 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 W 222 5x68 G.H5 Q 372 G.H5.17
Polar H8 N 404 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 404 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 404 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 143 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL3 R 233 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 R 233 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 L 141 34x51 G.S1 V 58 G.S1.02
Polar TM3 A 136 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 N 374 G.H5.19
Polar ICL2 R 145 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 145 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 145 34x55 G.hns1 R 56 G.hns1.03
Polar TM5 W 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 W 222 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 W 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 R 133 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 140 34x50 G.H5 L 371 G.H5.16
Polar TM3 R 133 3x50 G.H5 D 377 G.H5.22
Polar TM6 R 340 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 340 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 340 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 340 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 340 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM6 E 341 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 141 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 A 344 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 344 6x33 G.H5 M 379 G.H5.24
Polar H8 A 405 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM5 W 222 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 W 222 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 230 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 141 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 141 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 141 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 141 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM2 I 73 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 73 2x43 G.H5 L 380 G.H5.25
Polar ICL3 R 233 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 R 233 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 R 233 - G.S6 H 349 G.S6.04
Hydrophobic TM7 Y 400 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 400 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 136 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 338 6x27 G.h4s6 S 343 G.h4s6.12
Polar TM5 K 229 5x75 G.H5 H 364 G.H5.09
Hydrophobic TM5 K 229 5x75 G.H5 H 364 G.H5.09
Van-der-waals TM5 K 229 5x75 G.H5 H 364 G.H5.09
Hydrophobic TM6 A 344 6x33 G.H5 L 375 G.H5.20