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D5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | R | 273 | 5x86 | G.hgh4 | Y | 291 | G.hgh4.05 |
Hydrophobic | TM5 | R | 273 | 5x86 | G.hgh4 | Y | 291 | G.hgh4.05 |
Van-der-waals | TM5 | R | 273 | 5x86 | G.hgh4 | Y | 291 | G.hgh4.05 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | R | 258 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 258 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 258 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 258 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | I | 411 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | I | 411 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | I | 394 | - | G.H3 | M | 249 | G.H3.07 |
Hydrophobic | TM5 | A | 269 | 5x82 | G.H4 | A | 302 | G.H4.08 |
Van-der-waals | TM5 | A | 269 | 5x82 | G.H4 | A | 302 | G.H4.08 |
Polar | C-term | S | 390 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | S | 390 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | L | 393 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 393 | - | G.H3 | S | 253 | G.H3.11 |
Polar | TM3 | R | 138 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | I | 251 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 145 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | V | 387 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | V | 387 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM5 | A | 266 | 5x79 | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | TM5 | A | 266 | 5x79 | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL2 | R | 150 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | C-term | S | 395 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | S | 395 | - | G.H2 | E | 208 | G.H2.03 |
Van-der-waals | C-term | S | 395 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | L | 393 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM4 | Q | 154 | 4x39 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM4 | Q | 154 | 4x39 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | C-term | Y | 410 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | Y | 410 | - | H.hbhc | M | 114 | H.hbhc.02 |
Polar | H8 | N | 362 | 8x47 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | H8 | N | 362 | 8x47 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | C-term | I | 389 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | I | 389 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | N | 416 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | N | 416 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | C-term | A | 409 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | A | 409 | - | H.HA | Q | 79 | H.HA.17 |
Polar | TM5 | R | 273 | 5x86 | G.H4 | D | 299 | G.H4.05 |
Van-der-waals | TM5 | R | 273 | 5x86 | G.H4 | D | 299 | G.H4.05 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM6 | K | 290 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 290 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 290 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | L | 298 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 298 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | A | 252 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | I | 256 | 5x69 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | I | 400 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | T | 297 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | M | 414 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | TM6 | I | 301 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 301 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | I | 259 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | Q | 255 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | H | 412 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | C-term | H | 412 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | H | 412 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | T | 297 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 297 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Ionic | TM5 | R | 258 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | I | 406 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Van-der-waals | C-term | I | 406 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 273 | 5x86 | G.H4 | Y | 303 | G.H4.10 |
Van-der-waals | TM5 | R | 273 | 5x86 | G.H4 | Y | 303 | G.H4.10 |
Polar | C-term | Y | 396 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | C-term | Y | 396 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | Y | 396 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Polar | TM5 | Q | 270 | 5x83 | G.H4 | A | 306 | G.H4.13 |
Hydrophobic | TM5 | Q | 270 | 5x83 | G.H4 | A | 306 | G.H4.13 |
Van-der-waals | TM5 | Q | 270 | 5x83 | G.H4 | A | 306 | G.H4.13 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM5 | L | 262 | 5x75 | G.S6 | Y | 320 | G.S6.02 |
Polar | TM3 | A | 141 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 141 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 141 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | M | 414 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | M | 414 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM5 | R | 273 | 5x86 | G.hgh4 | G | 293 | G.hgh4.07 |
Van-der-waals | TM5 | R | 273 | 5x86 | G.hgh4 | G | 293 | G.hgh4.07 |
Hydrophobic | C-term | M | 414 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Hydrophobic | TM5 | I | 248 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 248 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 411 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Hydrophobic | C-term | I | 400 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Hydrophobic | C-term | M | 413 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | M | 413 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | C-term | L | 393 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | L | 393 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM5 | I | 248 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | N | 347 | G.H5.19 |