Gi2 - FFA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 Q 209 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 209 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM3 V 111 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 111 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 R 107 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 K 118 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 118 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL1 Q 40 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 Q 40 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 114 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 114 34x50 G.H5 T 341 G.H5.12
Polar ICL2 P 114 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 Y 117 34x53 G.H5 N 348 G.H5.19
Ionic ICL2 R 121 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 121 34x57 G.H5 D 351 G.H5.22
Polar TM6 R 216 6x30 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM6 R 216 6x30 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 R 216 6x30 G.h4s6 T 317 G.h4s6.10
Ionic TM1 R 35 1x60 G.H5 D 351 G.H5.22
Hydrophobic TM3 E 106 3x49 G.H5 C 352 G.H5.23
Polar TM2 H 45 2x40 G.H5 D 351 G.H5.22
Hydrophobic ICL2 V 115 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM6 L 223 6x37 G.H5 L 354 G.H5.25
Hydrophobic H8 S 277 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM5 F 202 5x61 G.H5 L 349 G.H5.20
Van-der-waals TM5 F 202 5x61 G.H5 L 349 G.H5.20
Polar C-term T 329 - G.H2 R 209 G.H2.04
Hydrophobic C-term T 329 - G.H2 R 209 G.H2.04
Van-der-waals C-term T 329 - G.H2 R 209 G.H2.04
Van-der-waals TM4 R 122 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals ICL3 L 211 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 V 115 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 115 34x51 G.S3 L 195 G.S3.01
Polar ICL2 K 118 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 118 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 111 3x54 G.H5 I 345 G.H5.16
Polar TM6 R 216 6x30 G.h4s6 D 316 G.h4s6.09
Polar TM3 G 110 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 110 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 110 3x53 G.H5 N 348 G.H5.19
Polar TM7 S 276 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 S 276 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 S 276 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 K 118 34x54 G.H5 I 344 G.H5.15
Polar C-term E 330 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term E 330 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term E 330 - G.s4h3 E 237 G.s4h3.10
Polar TM6 A 220 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 220 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 220 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 216 6x30 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 216 6x30 G.H5 F 355 G.H5.26
Hydrophobic TM5 M 206 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 M 206 5x65 G.H5 L 349 G.H5.20
Polar TM3 R 107 3x50 G.H5 G 353 G.H5.24
Polar TM6 R 219 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 219 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 219 6x33 G.H5 F 355 G.H5.26
Hydrophobic ICL3 L 211 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 211 - G.H5 D 342 G.H5.13
Polar TM3 R 107 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 107 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 107 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL3 L 211 - G.S6 Y 321 G.S6.02
Hydrophobic C-term E 330 - G.H2 R 206 G.H2.01
Van-der-waals C-term E 330 - G.H2 R 206 G.H2.01
Polar ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic C-term F 327 - G.s4h3 M 241 G.s4h3.14
Hydrophobic TM2 V 44 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 V 44 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL2 L 119 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 L 119 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 P 114 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 114 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 F 202 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 F 202 5x61 G.H5 L 354 G.H5.25
Ionic TM4 R 122 4x38 G.HN E 28 G.HN.52
Polar TM4 R 122 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 R 216 6x30 G.H5 K 346 G.H5.17
Van-der-waals TM6 R 216 6x30 G.H5 K 346 G.H5.17
Hydrophobic ICL2 P 114 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 114 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 K 118 34x54 G.S1 V 34 G.S1.02
Polar ICL1 Q 40 - G.HN G 27 G.HN.51
Van-der-waals ICL1 Q 40 - G.HN G 27 G.HN.51
Hydrophobic TM2 V 44 2x39 G.H5 C 352 G.H5.23
Polar ICL2 K 118 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 K 118 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 K 118 34x54 G.S1 E 33 G.S1.01
Polar H8 R 281 8x51 G.H5 F 355 G.H5.26
Van-der-waals H8 R 281 8x51 G.H5 F 355 G.H5.26
Hydrophobic C-term F 327 - G.H3 K 249 G.H3.07
Van-der-waals C-term F 327 - G.H3 K 249 G.H3.07