G12 -
FFA4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 356 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | L | 356 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | I | 140 | 3x54 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM6 | L | 266 | 6x38 | G.H5 | I | 378 | G.H5.23 |
Aromatic | ICL3 | Y | 247 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | ICL3 | Y | 247 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | Y | 247 | - | G.S6 | F | 347 | G.S6.02 |
Polar | ICL2 | R | 148 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | R | 148 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | R | 148 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | R | 145 | 34x52 | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 145 | 34x52 | G.h2s4 | T | 246 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 145 | 34x52 | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | TM7 | N | 322 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | Q | 144 | 34x51 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | Q | 144 | 34x51 | G.H5 | N | 374 | G.H5.19 |
Polar | ICL2 | G | 146 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM5 | L | 241 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | L | 241 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | Q | 144 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM5 | L | 245 | 5x76 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | L | 245 | 5x76 | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | TM5 | L | 245 | 5x76 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL3 | A | 246 | - | G.S6 | F | 347 | G.S6.02 |
Polar | TM6 | H | 251 | 6x23 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM6 | H | 251 | 6x23 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM6 | H | 251 | 6x23 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM6 | L | 262 | 6x34 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL3 | Y | 247 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | Y | 247 | - | G.H5 | D | 368 | G.H5.13 |
Polar | TM7 | T | 324 | 7x56 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM3 | C | 139 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | C | 139 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 143 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM7 | Y | 321 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 321 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | L | 262 | 6x34 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | L | 262 | 6x34 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | T | 234 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 143 | 34x50 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL3 | A | 246 | - | G.S6 | L | 346 | G.S6.01 |
Polar | TM7 | T | 324 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM7 | T | 324 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | T | 324 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 140 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM5 | I | 233 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM5 | R | 240 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | TM5 | R | 240 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM5 | S | 244 | 5x75 | G.H5 | F | 361 | G.H5.06 |
Polar | ICL3 | A | 246 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL3 | A | 246 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ICL3 | A | 246 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | I | 230 | 5x61 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | R | 261 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | TM6 | H | 251 | 6x23 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM6 | H | 251 | 6x23 | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | TM6 | H | 251 | 6x23 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | ICL3 | A | 246 | - | G.H5 | F | 361 | G.H5.06 |
Polar | ICL2 | R | 148 | 34x55 | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | TM5 | I | 230 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 140 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Ionic | ICL2 | R | 145 | 34x52 | G.H5 | E | 373 | G.H5.18 |
Polar | ICL2 | R | 145 | 34x52 | G.H5 | E | 373 | G.H5.18 |
Hydrophobic | ICL2 | R | 145 | 34x52 | G.H5 | E | 373 | G.H5.18 |
Van-der-waals | ICL2 | R | 145 | 34x52 | G.H5 | E | 373 | G.H5.18 |
Polar | ICL2 | R | 145 | 34x52 | G.h2s4 | I | 245 | G.h2s4.04 |
Hydrophobic | ICL2 | R | 145 | 34x52 | G.h2s4 | I | 245 | G.h2s4.04 |
Van-der-waals | ICL2 | R | 145 | 34x52 | G.h2s4 | I | 245 | G.h2s4.04 |
Polar | ICL2 | G | 149 | 34x56 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | G | 149 | 34x56 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | G | 149 | 34x56 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL3 | Y | 247 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | Y | 247 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM5 | T | 234 | 5x65 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM7 | L | 320 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | L | 320 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | T | 265 | 6x37 | G.H5 | M | 379 | G.H5.24 |
Polar | TM6 | R | 254 | 6x26 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | C-term | S | 350 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | S | 350 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | S | 350 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM5 | L | 241 | 5x72 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | L | 241 | 5x72 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | C-term | D | 348 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | L | 143 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Polar | ICL2 | R | 148 | 34x55 | G.hns1 | V | 54 | G.hns1.01 |
Van-der-waals | ICL2 | R | 148 | 34x55 | G.hns1 | V | 54 | G.hns1.01 |
Hydrophobic | TM6 | L | 262 | 6x34 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM7 | M | 323 | 7x55 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | M | 323 | 7x55 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | S | 237 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | S | 237 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Polar | TM5 | S | 237 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | S | 237 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | ICL2 | R | 145 | 34x52 | G.h2s4 | G | 244 | G.h2s4.03 |