G12 - FFA4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 265 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 140 3x54 G.H5 L 375 G.H5.20
Hydrophobic C-term D 348 - G.H3 K 284 G.H3.16
Hydrophobic TM5 T 234 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 230 5x61 G.H5 I 378 G.H5.23
Hydrophobic TM7 Y 321 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 321 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM7 N 322 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 262 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 262 6x34 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 233 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM3 I 140 3x54 G.H5 N 374 G.H5.19
Van-der-waals TM3 I 140 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM7 L 320 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 320 7x52 G.H5 L 380 G.H5.25
Polar TM5 S 237 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 237 5x68 G.H5 D 368 G.H5.13
Ionic ICL2 R 145 34x52 G.H5 E 373 G.H5.18
Polar ICL2 R 145 34x52 G.H5 E 373 G.H5.18
Hydrophobic ICL2 R 145 34x52 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 145 34x52 G.H5 E 373 G.H5.18
Polar ICL2 R 145 34x52 G.h2s4 I 245 G.h2s4.04
Hydrophobic ICL2 R 145 34x52 G.h2s4 I 245 G.h2s4.04
Van-der-waals ICL2 R 145 34x52 G.h2s4 I 245 G.h2s4.04
Polar ICL3 Y 247 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 Y 247 - G.H5 D 368 G.H5.13
Hydrophobic TM5 T 234 5x65 G.H5 L 371 G.H5.16
Polar TM3 C 139 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 139 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 262 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 230 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 143 34x50 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 143 34x50 G.S3 I 221 G.S3.01
Polar ICL2 R 145 34x52 G.h2s4 G 244 G.h2s4.03
Hydrophobic TM5 S 237 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 237 5x68 G.H5 L 371 G.H5.16
Aromatic ICL3 Y 247 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 Y 247 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 Y 247 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 A 246 - G.S6 L 346 G.S6.01
Hydrophobic TM6 R 261 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term L 356 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 356 - G.H2 Q 236 G.H2.05
Hydrophobic TM5 S 244 5x75 G.H5 F 361 G.H5.06
Hydrophobic ICL3 A 246 - G.H5 F 361 G.H5.06
Polar TM6 R 254 6x26 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 R 254 6x26 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM5 L 241 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 266 6x38 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 140 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 140 3x54 G.H5 L 371 G.H5.16
Polar ICL2 G 149 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 G 149 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 G 149 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 241 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 241 5x72 G.S6 F 347 G.S6.02
Polar ICL2 R 148 34x55 G.S1 L 57 G.S1.01
Polar ICL2 R 145 34x52 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 145 34x52 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 145 34x52 G.h2s4 T 246 G.h2s4.05
Polar ICL2 Q 144 34x51 G.H5 N 374 G.H5.19
Van-der-waals ICL2 Q 144 34x51 G.H5 N 374 G.H5.19
Hydrophobic ICL3 Y 247 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Y 247 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 143 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 143 34x50 G.H5 I 370 G.H5.15
Polar ICL2 R 148 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 148 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 148 34x55 G.hns1 R 55 G.hns1.02
Polar ICL3 A 246 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 A 246 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 A 246 - G.S6 H 348 G.S6.03
Polar TM6 H 251 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 H 251 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 H 251 6x23 G.h4s6 P 345 G.h4s6.20
Polar TM7 T 324 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 140 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 140 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Q 144 34x51 G.H5 I 370 G.H5.15
Polar C-term S 350 - G.H3 K 284 G.H3.16
Hydrophobic C-term S 350 - G.H3 K 284 G.H3.16
Van-der-waals C-term S 350 - G.H3 K 284 G.H3.16
Polar ICL2 G 146 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 262 6x34 G.H5 I 378 G.H5.23
Polar TM7 T 324 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 T 324 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 T 324 7x56 G.H5 L 380 G.H5.25
Polar TM5 L 245 5x76 G.S6 H 348 G.S6.03
Hydrophobic TM5 L 245 5x76 G.S6 H 348 G.S6.03
Van-der-waals TM5 L 245 5x76 G.S6 H 348 G.S6.03
Polar ICL2 R 148 34x55 G.hns1 V 54 G.hns1.01
Van-der-waals ICL2 R 148 34x55 G.hns1 V 54 G.hns1.01
Hydrophobic TM3 R 136 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 A 246 - G.S6 F 347 G.S6.02
Hydrophobic TM5 R 240 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 R 240 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL2 L 143 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 143 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM7 M 323 7x55 G.H5 L 380 G.H5.25
Van-der-waals TM7 M 323 7x55 G.H5 L 380 G.H5.25
Polar TM6 H 251 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 H 251 6x23 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 H 251 6x23 G.h4s6 K 344 G.h4s6.19