Gi3 - FFA4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 143 34x50 G.S3 L 194 G.S3.01
Polar ICL3 A 246 - G.S6 T 321 G.S6.03
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 143 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 143 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 269 6x41 G.H5 L 353 G.H5.25
Hydrophobic ICL2 G 146 34x53 G.H5 E 350 G.H5.22
Polar TM6 Q 258 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 Q 258 6x30 G.H5 Y 354 G.H5.26
Van-der-waals TM6 Q 258 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM5 L 241 5x72 G.H5 D 341 G.H5.13
Ionic TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 245 5x76 G.S6 H 322 G.S6.04
Van-der-waals TM5 L 245 5x76 G.S6 H 322 G.S6.04
Polar TM5 S 237 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 237 5x68 G.H5 D 341 G.H5.13
Polar TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 L 262 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM5 T 234 5x65 G.H5 L 348 G.H5.20
Ionic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 240 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Hydrophobic C-term G 361 - G.H2 R 205 G.H2.01
Van-der-waals C-term G 361 - G.H2 R 205 G.H2.01
Ionic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Polar TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Polar C-term S 360 - G.s4h3 E 236 G.s4h3.10
Hydrophobic C-term S 360 - G.s4h3 E 236 G.s4h3.10
Van-der-waals C-term S 360 - G.s4h3 E 236 G.s4h3.10
Hydrophobic TM5 L 245 5x76 G.S6 T 321 G.S6.03
Van-der-waals TM5 L 245 5x76 G.S6 T 321 G.S6.03
Hydrophobic TM3 I 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 S 244 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 S 244 5x75 G.H5 F 334 G.H5.06
Polar TM3 C 139 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 356 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 356 - G.H3 S 252 G.H3.11
Hydrophobic TM5 L 245 5x76 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 245 5x76 G.S6 Y 320 G.S6.02
Hydrophobic TM6 L 262 6x34 G.H5 L 353 G.H5.25
Polar ICL3 A 246 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 A 246 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 A 246 - G.H4 Q 304 G.H4.12
Polar ICL2 R 145 34x52 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 R 145 34x52 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 R 145 34x52 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM5 I 230 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM7 T 324 7x56 G.H5 Y 354 G.H5.26
Van-der-waals TM7 T 324 7x56 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 V 147 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL2 R 145 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic C-term I 359 - G.H3 L 249 G.H3.08
Hydrophobic TM6 T 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.25
Van-der-waals ICL2 R 145 34x52 G.H5 N 346 G.H5.18
Polar C-term N 354 - G.H2 K 209 G.H2.05
Polar ICL3 Y 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 C 139 3x53 G.H5 C 351 G.H5.23
Ionic TM6 R 254 6x26 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 254 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 254 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 254 6x26 G.h4s6 D 315 G.h4s6.09
Polar C-term G 361 - G.s4h3 E 236 G.s4h3.10
Hydrophobic C-term G 361 - G.s4h3 E 236 G.s4h3.10
Van-der-waals C-term G 361 - G.s4h3 E 236 G.s4h3.10
Polar TM5 S 244 5x75 G.S6 H 322 G.S6.04
Hydrophobic TM5 S 244 5x75 G.S6 H 322 G.S6.04
Van-der-waals TM5 S 244 5x75 G.S6 H 322 G.S6.04
Hydrophobic ICL2 L 143 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 143 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 143 34x50 G.H5 T 340 G.H5.12
Polar ICL2 Q 144 34x51 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 233 5x64 G.H5 I 344 G.H5.16
Ionic TM5 R 238 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 238 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 238 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 238 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 241 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 241 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 S 237 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 237 5x68 G.H5 I 344 G.H5.16
Polar ICL2 R 145 34x52 G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 R 145 34x52 G.h2s4 G 217 G.h2s4.03
Polar TM7 T 324 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 324 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 324 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Q 144 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 T 234 5x65 G.H5 I 344 G.H5.16
Polar ICL2 R 145 34x52 G.h2s4 V 218 G.h2s4.04
Hydrophobic ICL2 R 145 34x52 G.h2s4 V 218 G.h2s4.04
Hydrophobic C-term I 359 - G.H2 R 208 G.H2.04
Van-der-waals C-term I 359 - G.H2 R 208 G.H2.04
Hydrophobic TM6 L 266 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 246 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 A 246 - G.S6 F 323 G.S6.05
Hydrophobic C-term I 359 - G.H3 E 245 G.H3.04
Van-der-waals C-term I 359 - G.H3 E 245 G.H3.04
Van-der-waals ICL3 Y 247 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 140 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 241 5x72 G.H5 A 338 G.H5.10