G12 - FSH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 471 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 471 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 M 475 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 475 34x51 G.S3 I 221 G.S3.01
Polar C-term V 687 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term V 687 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term V 687 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM6 S 563 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 R 467 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 471 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 471 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 T 555 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 552 5x61 G.H5 L 375 G.H5.20
Polar TM3 R 467 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 467 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 467 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 471 3x54 G.H5 I 378 G.H5.23
Van-der-waals ICL2 A 474 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 477 34x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 477 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 R 573 6x36 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 573 6x36 G.H5 Q 381 G.H5.26
Polar TM6 S 563 6x26 G.H5 Q 372 G.H5.17
Hydrophobic H8 T 630 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 630 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 V 556 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 556 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 574 6x37 G.H5 L 375 G.H5.20
Hydrophobic ICL2 M 475 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 M 475 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM6 M 574 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 574 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL3 I 561 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 I 561 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 I 561 - G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 686 - H.HA D 110 H.HA.24
Van-der-waals C-term L 686 - H.HA D 110 H.HA.24
Hydrophobic TM3 T 470 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 T 470 3x53 G.H5 I 378 G.H5.23
Polar C-term N 664 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term N 664 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term N 664 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term Y 684 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term Y 684 - G.s4h3 M 262 G.s4h3.09
Polar C-term L 686 - H.HA K 114 H.HA.28
Hydrophobic C-term L 686 - H.HA K 114 H.HA.28
Van-der-waals C-term L 686 - H.HA K 114 H.HA.28
Polar TM3 T 470 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 T 470 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 T 470 3x53 G.H5 N 374 G.H5.19
Polar ICL3 N 558 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 N 558 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 N 558 - G.H5 D 368 G.H5.13
Hydrophobic TM6 I 570 6x33 G.H5 L 375 G.H5.20
Polar TM6 R 573 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 573 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 573 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 475 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 M 475 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 A 474 34x50 G.H5 L 371 G.H5.16
Polar TM4 Q 482 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 Q 482 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 Q 482 4x38 G.HN R 52 G.HN.52
Polar C-term N 680 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term N 680 - G.hfs2 K 209 G.hfs2.06
Hydrophobic ICL2 M 475 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 475 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 I 561 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 I 561 - G.H5 D 368 G.H5.13
Polar C-term V 678 - G.hfs2 K 209 G.hfs2.06
Polar C-term T 679 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term T 679 - G.hfs2 K 209 G.hfs2.06
Hydrophobic ICL2 M 475 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 475 34x51 G.H5 K 367 G.H5.12
Polar C-term I 685 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term I 685 - G.s4h3 R 265 G.s4h3.12
Polar C-term C 672 - G.H2 Q 240 G.H2.09
Hydrophobic C-term C 672 - G.H2 Q 240 G.H2.09
Van-der-waals C-term C 672 - G.H2 Q 240 G.H2.09
Hydrophobic TM6 I 570 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 477 34x53 G.hns1 R 56 G.hns1.03
Polar TM6 R 573 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 573 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 573 6x36 G.H5 M 379 G.H5.24
Polar TM6 S 566 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 Q 476 34x52 G.S3 I 221 G.S3.01
Polar H8 K 631 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 631 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 631 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 686 - H.HA V 107 H.HA.21
Polar ICL2 D 478 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 478 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 478 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic C-term P 688 - H.HA K 114 H.HA.28
Hydrophobic TM7 Y 626 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 626 7x53 G.H5 L 380 G.H5.25
Hydrophobic C-term N 664 - G.H3 L 285 G.H3.17
Van-der-waals C-term N 664 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 A 474 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 474 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 M 475 34x51 G.H5 V 366 G.H5.11