G12 - FZD10 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 74.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.4
iPTM Score: 0.2
PAE mean: 29.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 437 - G.H5 Q 372 G.H5.17
Hydrophobic TM5 V 426 5x75 G.s2s3 K 220 G.s2s3.02
Van-der-waals TM5 V 426 5x75 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 K 341 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 341 - G.H5 N 374 G.H5.19
Polar TM4 A 346 4x37 G.H5 D 377 G.H5.22
Hydrophobic TM4 A 346 4x37 G.H5 D 377 G.H5.22
Van-der-waals TM4 A 346 4x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 336 3x52 G.H5 D 377 G.H5.22
Van-der-waals TM3 L 336 3x52 G.H5 D 377 G.H5.22
Polar TM5 H 422 5x71 G.hns1 R 56 G.hns1.03
Aromatic TM5 H 422 5x71 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 H 422 5x71 G.hns1 R 56 G.hns1.03
Van-der-waals TM5 H 422 5x71 G.hns1 R 56 G.hns1.03
Polar TM3 L 336 3x52 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 336 3x52 G.H5 L 380 G.H5.25
Van-der-waals TM3 L 336 3x52 G.H5 L 380 G.H5.25
Ionic ICL3 E 432 - G.s2s3 K 219 G.s2s3.01
Polar ICL3 E 432 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL3 E 432 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL3 E 432 - G.s2s3 K 219 G.s2s3.01
Hydrophobic TM2 P 259 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 P 259 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 W 342 - G.h2s4 I 245 G.h2s4.04
Van-der-waals TM3 G 339 3x55 G.hns1 R 55 G.hns1.02
Polar TM3 T 333 3x49 G.H5 M 379 G.H5.24
Hydrophobic TM3 T 333 3x49 G.H5 M 379 G.H5.24
Van-der-waals TM3 T 333 3x49 G.H5 M 379 G.H5.24
Polar ICL2 K 340 - G.H5 I 378 G.H5.23
Hydrophobic ICL2 K 340 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 K 340 - G.H5 I 378 G.H5.23
Polar TM3 T 333 3x49 G.H5 L 380 G.H5.25
Hydrophobic TM3 T 333 3x49 G.H5 L 380 G.H5.25
Van-der-waals TM3 T 333 3x49 G.H5 L 380 G.H5.25
Polar ICL3 G 430 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL3 G 430 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL3 G 430 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 K 341 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 K 341 - G.H5 I 378 G.H5.23
Polar TM5 A 419 5x68 G.hns1 R 56 G.hns1.03
Van-der-waals TM5 A 419 5x68 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 341 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 K 341 - G.S3 I 221 G.S3.01
Polar TM3 A 337 3x53 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 337 3x53 G.H5 M 379 G.H5.24
Van-der-waals TM3 A 337 3x53 G.H5 M 379 G.H5.24
Polar ICL2 K 340 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 340 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 340 - G.hns1 R 56 G.hns1.03
Ionic ICL3 E 432 - G.H5 H 364 G.H5.09
Polar ICL3 E 432 - G.H5 H 364 G.H5.09
Polar TM3 W 334 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 W 334 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 W 334 3x50 G.H5 M 379 G.H5.24
Polar TM3 A 338 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 338 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 A 338 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 K 341 - G.S1 V 58 G.S1.02
Polar TM4 G 343 4x34 G.H5 E 373 G.H5.18
Hydrophobic TM4 G 343 4x34 G.H5 E 373 G.H5.18
Van-der-waals TM4 G 343 4x34 G.H5 E 373 G.H5.18
Polar TM3 L 336 3x52 G.H5 Q 381 G.H5.26
Hydrophobic TM3 L 336 3x52 G.H5 Q 381 G.H5.26
Van-der-waals TM3 L 336 3x52 G.H5 Q 381 G.H5.26
Van-der-waals ICL2 K 340 - G.hns1 V 54 G.hns1.01
Hydrophobic TM4 I 347 4x38 G.H5 L 380 G.H5.25
Van-der-waals TM4 I 347 4x38 G.H5 L 380 G.H5.25
Hydrophobic ICL2 K 341 - G.H5 L 371 G.H5.16
Hydrophobic TM3 A 338 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 A 338 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 337 3x53 G.H5 L 380 G.H5.25
Van-der-waals TM3 A 337 3x53 G.H5 L 380 G.H5.25
Polar TM4 A 349 4x40 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM4 A 349 4x40 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM4 A 349 4x40 G.h3s5 N 288 G.h3s5.02
Polar TM4 H 344 4x35 G.H5 K 376 G.H5.21
Hydrophobic TM4 H 344 4x35 G.H5 K 376 G.H5.21
Van-der-waals TM4 H 344 4x35 G.H5 K 376 G.H5.21
Hydrophobic TM4 A 346 4x37 G.H5 Q 381 G.H5.26
Van-der-waals TM4 A 346 4x37 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 W 342 - G.H5 E 373 G.H5.18
Van-der-waals ICL2 W 342 - G.H5 E 373 G.H5.18
Polar TM3 A 337 3x53 G.H5 K 376 G.H5.21
Hydrophobic TM3 A 337 3x53 G.H5 K 376 G.H5.21
Van-der-waals TM3 A 337 3x53 G.H5 K 376 G.H5.21
Hydrophobic TM2 Y 258 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 258 2x39 G.H5 L 380 G.H5.25
Polar ICL2 K 340 - G.H5 Q 381 G.H5.26
Hydrophobic ICL2 K 340 - G.H5 Q 381 G.H5.26
Van-der-waals ICL2 K 340 - G.H5 Q 381 G.H5.26
Polar TM3 A 338 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 338 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 338 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 W 342 - G.H5 Q 381 G.H5.26
Van-der-waals ICL2 W 342 - G.H5 Q 381 G.H5.26
Polar ICL3 G 431 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL3 G 431 - G.s2s3 K 219 G.s2s3.01
Hydrophobic TM4 I 347 4x38 G.H5 D 377 G.H5.22
Van-der-waals TM4 I 347 4x38 G.H5 D 377 G.H5.22
Polar TM3 A 337 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM3 A 337 3x53 G.H5 D 377 G.H5.22
Van-der-waals TM3 A 337 3x53 G.H5 D 377 G.H5.22
Hydrophobic ICL3 L 437 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 437 - G.H5 L 375 G.H5.20
Hydrophobic ICL1 R 257 12x51 G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL1 R 257 12x51 G.h4s6 P 345 G.h4s6.20
Polar TM4 I 347 4x38 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM4 I 347 4x38 G.h3s5 N 288 G.h3s5.02
Hydrophobic N-term R 62 - G.H3 K 284 G.H3.16
Hydrophobic TM4 A 349 4x40 G.h3s5 F 287 G.h3s5.01
Van-der-waals TM4 A 349 4x40 G.h3s5 F 287 G.h3s5.01
Polar TM3 G 339 3x55 G.H5 I 378 G.H5.23
Hydrophobic TM3 G 339 3x55 G.H5 I 378 G.H5.23
Van-der-waals TM3 G 339 3x55 G.H5 I 378 G.H5.23
Polar ICL3 T 429 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL3 T 429 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL3 T 429 - G.s2s3 K 220 G.s2s3.02
Hydrophobic TM3 L 332 3x48 G.H5 M 379 G.H5.24
Van-der-waals TM3 L 332 3x48 G.H5 M 379 G.H5.24
Polar TM3 A 337 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 337 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 337 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 K 341 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 341 - G.hns1 R 56 G.hns1.03
Hydrophobic TM4 E 345 4x36 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM4 E 345 4x36 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM4 F 354 4x45 G.H5 L 380 G.H5.25
Van-der-waals TM4 F 354 4x45 G.H5 L 380 G.H5.25
Polar TM3 L 336 3x52 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 336 3x52 G.H5 M 379 G.H5.24
Van-der-waals TM3 L 336 3x52 G.H5 M 379 G.H5.24
Polar ICL2 W 342 - G.H5 K 376 G.H5.21
Polar ICL2 W 342 - G.H5 L 375 G.H5.20
Polar TM4 H 344 4x35 G.H5 D 377 G.H5.22
Van-der-waals TM4 H 344 4x35 G.H5 D 377 G.H5.22
Polar TM4 E 345 4x36 G.H5 D 377 G.H5.22
Van-der-waals TM4 E 345 4x36 G.H5 D 377 G.H5.22
Polar ICL2 W 342 - G.h2s4 G 244 G.h2s4.03
Hydrophobic ICL2 W 342 - G.h2s4 G 244 G.h2s4.03
Van-der-waals ICL2 W 342 - G.h2s4 G 244 G.h2s4.03
Hydrophobic TM4 I 347 4x38 G.H5 K 376 G.H5.21
Van-der-waals TM4 I 347 4x38 G.H5 K 376 G.H5.21
Polar ICL2 K 340 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 340 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 340 - G.hns1 R 55 G.hns1.02
Polar TM4 G 343 4x34 G.H5 D 377 G.H5.22
Hydrophobic TM4 G 343 4x34 G.H5 D 377 G.H5.22
Van-der-waals TM4 G 343 4x34 G.H5 D 377 G.H5.22
Polar TM4 A 346 4x37 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM4 A 346 4x37 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM4 A 346 4x37 G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL2 K 341 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 K 341 - G.H5 L 375 G.H5.20
Van-der-waals TM4 N 350 4x41 G.H5 Q 381 G.H5.26
Hydrophobic TM5 I 423 5x72 G.hns1 R 56 G.hns1.03
Van-der-waals TM5 I 423 5x72 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 G 343 4x34 G.H5 N 374 G.H5.19
Hydrophobic TM4 E 345 4x36 G.h3s5 V 289 G.h3s5.03
Polar TM3 A 337 3x53 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 337 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 A 337 3x53 G.H5 L 375 G.H5.20
Hydrophobic TM4 H 344 4x35 G.S6 F 347 G.S6.02
Polar ICL2 W 342 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 W 342 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 W 342 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 W 342 - G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 W 342 - G.h2s4 T 246 G.h2s4.05
Hydrophobic TM3 F 335 3x51 G.H5 I 378 G.H5.23
Van-der-waals TM3 F 335 3x51 G.H5 I 378 G.H5.23
Hydrophobic TM3 F 335 3x51 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 F 335 3x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 L 437 - G.H5 K 376 G.H5.21
Polar ICL2 K 341 - G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 K 341 - G.h2s4 T 246 G.h2s4.05
Polar TM4 N 350 4x41 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM4 N 350 4x41 G.h3s5 N 288 G.h3s5.02
Ionic ICL3 E 432 - G.H5 K 367 G.H5.12
Polar ICL3 E 432 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 E 432 - G.H5 K 367 G.H5.12
Van-der-waals ICL3 E 432 - G.H5 K 367 G.H5.12
Polar TM3 F 335 3x51 G.H5 M 379 G.H5.24
Hydrophobic TM3 F 335 3x51 G.H5 M 379 G.H5.24
Van-der-waals TM3 F 335 3x51 G.H5 M 379 G.H5.24
Ionic TM4 E 345 4x36 G.h4s6 K 344 G.h4s6.19
Polar TM4 E 345 4x36 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM4 E 345 4x36 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM4 E 345 4x36 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM4 I 347 4x38 G.H5 Q 381 G.H5.26
Polar TM4 G 343 4x34 G.H5 K 376 G.H5.21
Hydrophobic TM4 G 343 4x34 G.H5 K 376 G.H5.21
Van-der-waals TM4 G 343 4x34 G.H5 K 376 G.H5.21
Polar ICL2 W 342 - G.H5 I 378 G.H5.23
Hydrophobic ICL2 W 342 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 W 342 - G.H5 I 378 G.H5.23
Hydrophobic TM6 M 441 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 441 6x30 G.H5 M 379 G.H5.24
Hydrophobic TM5 M 427 5x76 G.S3 I 221 G.S3.01
Van-der-waals TM5 M 427 5x76 G.S3 I 221 G.S3.01
Hydrophobic TM5 H 422 5x71 G.HN R 52 G.HN.52
Hydrophobic TM2 P 259 2x40 G.H5 K 376 G.H5.21
Ionic TM4 E 348 4x39 G.h4s6 K 344 G.h4s6.19
Polar TM4 E 348 4x39 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM4 E 348 4x39 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM4 E 348 4x39 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM4 E 348 4x39 G.h3s5 F 287 G.h3s5.01
Van-der-waals TM4 E 348 4x39 G.h3s5 F 287 G.h3s5.01
Hydrophobic TM6 M 441 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 M 441 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM4 E 345 4x36 G.S5 S 290 G.S5.01
Van-der-waals TM4 E 345 4x36 G.S5 S 290 G.S5.01
Polar TM3 L 336 3x52 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 336 3x52 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 336 3x52 G.H5 I 378 G.H5.23
Polar TM2 Y 258 2x39 G.H5 K 376 G.H5.21
Hydrophobic TM2 Y 258 2x39 G.H5 K 376 G.H5.21
Van-der-waals TM2 Y 258 2x39 G.H5 K 376 G.H5.21
Ionic TM4 H 344 4x35 G.H5 E 373 G.H5.18
Polar TM4 H 344 4x35 G.H5 E 373 G.H5.18
Hydrophobic TM4 H 344 4x35 G.H5 E 373 G.H5.18
Van-der-waals TM4 H 344 4x35 G.H5 E 373 G.H5.18
Polar ICL2 W 342 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 W 342 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 W 342 - G.H5 N 374 G.H5.19