Gt2 - FZD6 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 72.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM4 Q 322 4x40 G.HN A 27 G.HN.51
Hydrophobic TM4 Q 322 4x40 G.HN A 27 G.HN.51
Van-der-waals TM4 Q 322 4x40 G.HN A 27 G.HN.51
Hydrophobic TM5 I 400 5x76 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 396 5x72 G.H5 L 348 G.H5.20
Hydrophobic C-term I 554 - H.hdhe Y 146 H.hdhe.01
Ionic ICL2 K 314 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 314 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 314 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 A 310 3x53 G.H5 L 348 G.H5.20
Hydrophobic C-term F 530 - G.H2 R 208 G.H2.04
Van-der-waals C-term F 530 - G.H2 R 208 G.H2.04
Hydrophobic TM5 L 393 5x69 G.H5 L 348 G.H5.20
Van-der-waals C-term T 570 - G.S2 E 186 G.S2.03
Polar C-term S 555 - G.s4h3 V 235 G.s4h3.09
Hydrophobic C-term S 555 - G.s4h3 V 235 G.s4h3.09
Van-der-waals C-term S 555 - G.s4h3 V 235 G.s4h3.09
Ionic C-term H 568 - H.HA E 68 H.HA.06
Polar C-term H 568 - H.HA E 68 H.HA.06
Hydrophobic C-term H 568 - H.HA E 68 H.HA.06
Van-der-waals C-term H 568 - H.HA E 68 H.HA.06
Ionic TM4 K 323 4x41 G.HN D 28 G.HN.52
Polar TM4 K 323 4x41 G.HN D 28 G.HN.52
Hydrophobic TM4 K 323 4x41 G.HN D 28 G.HN.52
Van-der-waals TM4 K 323 4x41 G.HN D 28 G.HN.52
Polar C-term T 560 - G.hfs2 K 180 G.hfs2.04
Hydrophobic C-term T 560 - G.hfs2 K 180 G.hfs2.04
Van-der-waals C-term T 560 - G.hfs2 K 180 G.hfs2.04
Hydrophobic C-term V 573 - G.S2 E 186 G.S2.03
Hydrophobic C-term S 557 - G.s4h3 V 235 G.s4h3.09
Van-der-waals C-term S 557 - G.s4h3 V 235 G.s4h3.09
Polar TM4 Q 322 4x40 G.HN D 28 G.HN.52
Polar TM4 S 316 4x34 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 S 316 4x34 G.hns1 A 31 G.hns1.02
Hydrophobic C-term V 522 - G.h4s6 M 312 G.h4s6.03
Hydrophobic ICL2 K 314 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 314 - G.S3 L 194 G.S3.01
Hydrophobic C-term T 562 - G.hfs2 V 179 G.hfs2.03
Van-der-waals C-term T 562 - G.hfs2 V 179 G.hfs2.03
Hydrophobic C-term I 554 - H.HA T 90 H.HA.28
Van-der-waals C-term I 554 - H.HA T 90 H.HA.28
Hydrophobic TM3 A 311 3x54 G.H5 L 348 G.H5.20
Hydrophobic C-term V 573 - G.S3 F 199 G.S3.06
Hydrophobic TM6 F 413 6x29 G.H5 G 352 G.H5.24
Van-der-waals TM6 F 413 6x29 G.H5 G 352 G.H5.24
Hydrophobic TM4 E 318 4x36 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 I 417 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 417 6x33 G.H5 L 353 G.H5.25
Hydrophobic C-term L 523 - G.H3 H 256 G.H3.15
Van-der-waals C-term L 523 - G.H3 H 256 G.H3.15
Polar C-term S 557 - G.s1h1 E 43 G.s1h1.04
Polar C-term S 555 - G.s4h3 L 234 G.s4h3.08
Van-der-waals C-term S 555 - G.s4h3 L 234 G.s4h3.08
Hydrophobic C-term G 559 - G.hfs2 K 180 G.hfs2.04
Hydrophobic TM3 A 310 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 310 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term V 553 - H.hdhe Y 146 H.hdhe.01
Hydrophobic TM2 E 231 2x41 G.H5 G 352 G.H5.24
Hydrophobic TM2 P 230 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 230 2x40 G.H5 C 351 G.H5.23
Ionic ICL1 R 228 12x51 G.H5 D 350 G.H5.22
Polar ICL1 R 228 12x51 G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 228 12x51 G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 228 12x51 G.H5 D 350 G.H5.22
Polar C-term I 516 - G.H3 K 257 G.H3.16
Van-der-waals C-term I 516 - G.H3 K 257 G.H3.16
Polar C-term V 553 - H.HD E 145 H.HD.12
Hydrophobic C-term V 553 - H.HD E 145 H.HD.12
Van-der-waals C-term V 553 - H.HD E 145 H.HD.12
Hydrophobic TM3 A 310 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 A 310 3x53 G.H5 L 353 G.H5.25
Hydrophobic C-term I 554 - H.HA R 86 H.HA.24
Ionic C-term K 550 - G.s4h3 E 239 G.s4h3.13
Polar C-term K 550 - G.s4h3 E 239 G.s4h3.13
Van-der-waals C-term K 550 - G.s4h3 E 239 G.s4h3.13
Polar C-term S 519 - G.H3 K 257 G.H3.16
Hydrophobic C-term S 519 - G.H3 K 257 G.H3.16
Van-der-waals C-term S 519 - G.H3 K 257 G.H3.16
Polar C-term T 560 - H.HA N 76 H.HA.14
Hydrophobic TM4 A 319 4x37 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 A 319 4x37 G.hns1 A 31 G.hns1.02
Polar ICL2 K 314 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 K 314 - G.s2s3 K 192 G.s2s3.01
Hydrophobic TM4 Q 322 4x40 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 Q 322 4x40 G.hns1 A 31 G.hns1.02
Hydrophobic C-term V 553 - H.hdhe Q 147 H.hdhe.02
Van-der-waals C-term V 553 - H.hdhe Q 147 H.hdhe.02
Hydrophobic C-term T 562 - H.HA I 72 H.HA.10
Hydrophobic TM5 V 396 5x72 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 396 5x72 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 410 6x26 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 399 5x75 G.s2s3 K 192 G.s2s3.01
Van-der-waals TM5 V 399 5x75 G.s2s3 K 192 G.s2s3.01
Polar C-term T 560 - G.hfs2 R 178 G.hfs2.02
Hydrophobic C-term F 530 - G.H3 L 249 G.H3.08
Van-der-waals C-term F 530 - G.H3 L 249 G.H3.08
Hydrophobic TM4 A 319 4x37 G.hns1 K 32 G.hns1.03
Polar ICL2 K 314 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 314 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 314 - G.H5 I 344 G.H5.16
Hydrophobic C-term T 560 - H.hbhc E 116 H.hbhc.04
Van-der-waals C-term T 560 - H.hbhc E 116 H.hbhc.04
Ionic TM6 K 409 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 409 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term I 554 - H.HA A 87 H.HA.25
Van-der-waals C-term I 554 - H.HA A 87 H.HA.25
Hydrophobic TM4 S 316 4x34 G.H5 C 351 G.H5.23
Hydrophobic TM6 N 406 6x22 G.H5 F 354 G.H5.26
Hydrophobic C-term F 530 - G.H3 S 252 G.H3.11
Polar C-term N 534 - G.H2 R 205 G.H2.01
Hydrophobic TM6 F 413 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 413 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM4 C 317 4x35 G.H5 C 351 G.H5.23
Hydrophobic C-term S 557 - H.hdhe Q 147 H.hdhe.02
Polar C-term S 555 - H.hdhe Q 147 H.hdhe.02
Hydrophobic C-term S 555 - H.hdhe Q 147 H.hdhe.02
Van-der-waals C-term S 555 - H.hdhe Q 147 H.hdhe.02
Hydrophobic ICL3 H 402 - G.H5 D 337 G.H5.09
Hydrophobic C-term T 570 - G.S2 I 185 G.S2.02
Hydrophobic TM6 L 410 6x26 G.H5 L 348 G.H5.20
Hydrophobic ICL3 H 402 - G.H5 A 338 G.H5.10
Hydrophobic C-term L 551 - H.HD E 145 H.HD.12
Van-der-waals C-term L 551 - H.HD E 145 H.HD.12
Hydrophobic C-term R 520 - G.H3 K 257 G.H3.16
Van-der-waals C-term R 520 - G.H3 K 257 G.H3.16
Polar C-term S 555 - G.s4h3 D 238 G.s4h3.12
Hydrophobic C-term S 555 - G.s4h3 D 238 G.s4h3.12
Van-der-waals C-term S 555 - G.s4h3 D 238 G.s4h3.12
Hydrophobic C-term V 553 - G.s4h3 V 233 G.s4h3.07
Van-der-waals C-term V 553 - G.s4h3 V 233 G.s4h3.07
Polar ICL3 H 402 - G.H5 F 334 G.H5.06
Aromatic ICL3 H 402 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 H 402 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 H 402 - G.H5 F 334 G.H5.06
Polar TM6 N 406 6x22 G.H5 K 345 G.H5.17
Hydrophobic TM6 N 406 6x22 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 406 6x22 G.H5 K 345 G.H5.17
Polar C-term K 552 - H.HA T 90 H.HA.28
Hydrophobic C-term K 552 - H.HA T 90 H.HA.28
Hydrophobic TM5 I 400 5x76 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 400 5x76 G.H5 D 341 G.H5.13
Polar C-term M 558 - H.HA Q 79 H.HA.17
Hydrophobic C-term M 558 - H.HA Q 79 H.HA.17
Van-der-waals C-term M 558 - H.HA Q 79 H.HA.17
Polar C-term I 554 - H.hdhe Q 147 H.hdhe.02
Hydrophobic C-term I 554 - H.hdhe Q 147 H.hdhe.02
Hydrophobic C-term L 523 - G.H3 K 257 G.H3.16
Van-der-waals C-term L 523 - G.H3 K 257 G.H3.16
Polar C-term S 571 - G.S2 E 186 G.S2.03
Van-der-waals C-term S 571 - G.S2 E 186 G.S2.03
Hydrophobic TM6 F 413 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 F 413 6x29 G.H5 F 354 G.H5.26
Hydrophobic C-term S 561 - G.hfs2 K 180 G.hfs2.04
Polar C-term Y 544 - G.s4h3 E 239 G.s4h3.13
Hydrophobic C-term Y 544 - G.s4h3 E 239 G.s4h3.13
Van-der-waals C-term Y 544 - G.s4h3 E 239 G.s4h3.13
Ionic C-term H 568 - H.HA E 65 H.HA.03
Polar C-term H 568 - H.HA E 65 H.HA.03
Hydrophobic C-term H 568 - H.HA E 65 H.HA.03
Van-der-waals C-term H 568 - H.HA E 65 H.HA.03
Hydrophobic TM3 W 307 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 W 307 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM4 I 320 4x38 G.H5 C 351 G.H5.23
Aromatic C-term F 529 - G.H3 H 248 G.H3.07
Hydrophobic C-term F 529 - G.H3 H 248 G.H3.07
Van-der-waals C-term F 529 - G.H3 H 248 G.H3.07
Hydrophobic C-term I 575 - G.H2 K 210 G.H2.06
Aromatic ICL2 W 315 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 W 315 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 W 315 - G.hns1 K 32 G.hns1.03
Polar TM5 Q 401 5x77 G.H5 D 341 G.H5.13
Hydrophobic C-term I 575 - G.H2 H 213 G.H2.09
Hydrophobic C-term T 560 - H.HA Q 79 H.HA.17
Polar C-term V 573 - G.S2 I 184 G.S2.01
Hydrophobic C-term V 573 - G.S2 I 184 G.S2.01
Van-der-waals C-term V 573 - G.S2 I 184 G.S2.01
Hydrophobic TM6 K 409 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 409 6x25 G.H5 F 354 G.H5.26
Polar C-term S 526 - G.H3 S 252 G.H3.11
Hydrophobic C-term S 526 - G.H3 S 252 G.H3.11
Van-der-waals C-term S 526 - G.H3 S 252 G.H3.11
Hydrophobic C-term I 575 - G.S2 I 184 G.S2.01
Van-der-waals C-term I 575 - G.S2 I 184 G.S2.01
Polar ICL2 W 315 - G.H5 C 351 G.H5.23
Hydrophobic TM3 A 311 3x54 G.H5 L 353 G.H5.25