Go - FZD7 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals N-term F 140 - G.hfs2 K 181 G.hfs2.04
Hydrophobic N-term F 140 - G.hfs2 V 180 G.hfs2.03
Van-der-waals N-term F 140 - G.hfs2 V 180 G.hfs2.03
Hydrophobic N-term F 138 - H.HA Y 69 H.HA.07
Polar N-term K 137 - G.H1 K 54 G.H1.09
Van-der-waals N-term K 137 - G.H1 K 54 G.H1.09
Polar ICL2 W 369 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 W 369 - G.H5 G 352 G.H5.24
Van-der-waals ICL2 W 369 - G.H5 G 352 G.H5.24
Polar N-term Q 141 - G.S2 I 185 G.S2.01
Hydrophobic N-term Q 141 - G.S2 I 185 G.S2.01
Van-der-waals N-term Q 141 - G.S2 I 185 G.S2.01
Polar TM4 G 370 4x34 G.H5 R 349 G.H5.21
Hydrophobic TM4 G 370 4x34 G.H5 R 349 G.H5.21
Van-der-waals TM4 G 370 4x34 G.H5 R 349 G.H5.21
Polar N-term K 91 - H.hbhc T 117 H.hbhc.05
Van-der-waals N-term K 91 - H.hbhc T 117 H.hbhc.05
Polar ICL2 K 368 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 368 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 K 368 - G.H5 C 351 G.H5.23
Hydrophobic TM5 I 450 5x72 G.H5 C 351 G.H5.23
Ionic N-term K 91 - H.hbhc E 118 H.hbhc.12
Polar N-term K 91 - H.hbhc E 118 H.hbhc.12
Hydrophobic N-term K 91 - H.hbhc E 118 H.hbhc.12
Van-der-waals N-term K 91 - H.hbhc E 118 H.hbhc.12
Hydrophobic N-term G 139 - G.S2 V 186 G.S2.02
Van-der-waals N-term G 139 - G.S2 V 186 G.S2.02
Ionic N-term K 137 - H.HA D 65 H.HA.03
Polar TM3 A 364 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 364 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 364 3x53 G.H5 C 351 G.H5.23
Polar TM4 H 371 4x35 G.H5 Y 354 G.H5.26
Hydrophobic TM4 H 371 4x35 G.H5 Y 354 G.H5.26
Van-der-waals TM4 H 371 4x35 G.H5 Y 354 G.H5.26
Hydrophobic N-term Y 87 - H.hbhc T 117 H.hbhc.05
Van-der-waals N-term Y 87 - H.hbhc T 117 H.hbhc.05
Polar ICL2 W 369 - G.H5 G 350 G.H5.22
Hydrophobic ICL2 W 369 - G.H5 G 350 G.H5.22
Van-der-waals ICL2 W 369 - G.H5 G 350 G.H5.22
Hydrophobic N-term F 138 - H.HA Q 68 H.HA.06
Van-der-waals N-term F 138 - H.HA Q 68 H.HA.06
Hydrophobic TM3 A 364 3x53 G.H5 G 352 G.H5.24
Van-der-waals TM3 A 364 3x53 G.H5 G 352 G.H5.24
Hydrophobic TM2 P 285 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 P 285 2x40 G.H5 G 352 G.H5.24
Ionic N-term H 84 - H.hbhc D 116 H.hbhc.04
Hydrophobic N-term H 84 - H.hbhc D 116 H.hbhc.04
Van-der-waals N-term H 84 - H.hbhc D 116 H.hbhc.04
Ionic N-term E 144 - G.H2 K 211 G.H2.06
Polar TM4 G 370 4x34 G.H5 G 350 G.H5.22
Hydrophobic TM4 G 370 4x34 G.H5 G 350 G.H5.22
Van-der-waals TM4 G 370 4x34 G.H5 G 350 G.H5.22
Hydrophobic TM5 L 447 5x69 G.H5 L 353 G.H5.25
Hydrophobic ICL2 W 369 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 W 369 - G.H5 C 351 G.H5.23
Hydrophobic N-term L 134 - H.HA Q 68 H.HA.06
Hydrophobic N-term P 55 - H.hbhc M 114 H.hbhc.02
Van-der-waals N-term P 55 - H.hbhc M 114 H.hbhc.02
Hydrophobic N-term G 80 - H.hbhc M 114 H.hbhc.02
Van-der-waals N-term G 80 - H.hbhc M 114 H.hbhc.02
Hydrophobic TM5 I 453 5x75 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 453 5x75 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 464 6x26 G.H5 L 353 G.H5.25
Polar TM3 G 366 3x55 G.H5 C 351 G.H5.23
Hydrophobic TM3 G 366 3x55 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 365 3x54 G.H5 L 353 G.H5.25
Hydrophobic N-term V 92 - H.HA Q 68 H.HA.06
Polar TM3 A 365 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 365 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 365 3x54 G.H5 C 351 G.H5.23
Hydrophobic N-term D 187 - G.HN T 4 G.HN.10
Van-der-waals N-term D 187 - G.HN T 4 G.HN.10
Hydrophobic TM4 G 370 4x34 G.H5 Y 354 G.H5.26
Van-der-waals TM4 G 370 4x34 G.H5 Y 354 G.H5.26
Polar N-term H 84 - H.hbhc M 114 H.hbhc.02
Hydrophobic N-term H 84 - H.hbhc M 114 H.hbhc.02
Van-der-waals N-term H 84 - H.hbhc M 114 H.hbhc.02
Polar ICL2 K 368 - G.H5 G 350 G.H5.22
Hydrophobic ICL2 K 368 - G.H5 G 350 G.H5.22
Van-der-waals ICL2 K 368 - G.H5 G 350 G.H5.22
Hydrophobic TM4 G 370 4x34 G.H5 G 352 G.H5.24
Van-der-waals TM3 A 364 3x53 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 450 5x72 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 450 5x72 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 467 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 467 6x29 G.H5 L 353 G.H5.25
Polar ICL2 K 368 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 368 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 368 - G.H5 N 347 G.H5.19
Hydrophobic TM4 I 374 4x38 G.H5 G 352 G.H5.24
Van-der-waals TM4 I 374 4x38 G.H5 G 352 G.H5.24