G12 - FZD9 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.4
iPTM Score: 0.4
PAE mean: 29.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM4 H 348 4x35 G.H3 K 284 G.H3.16
Hydrophobic C-term T 589 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 K 345 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 345 - G.H5 N 374 G.H5.19
Hydrophobic C-term P 588 - H.HA R 106 H.HA.20
Hydrophobic C-term L 591 - H.HA K 114 H.HA.28
Van-der-waals C-term L 591 - H.HA K 114 H.HA.28
Polar TM4 H 348 4x35 G.H3 F 286 G.H3.18
Hydrophobic TM4 H 348 4x35 G.H3 F 286 G.H3.18
Polar ICL2 K 344 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 344 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 344 - G.hns1 R 55 G.hns1.02
Hydrophobic TM5 M 431 5x76 G.H5 K 376 G.H5.21
Van-der-waals TM5 M 431 5x76 G.H5 K 376 G.H5.21
Hydrophobic TM5 L 424 5x69 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 424 5x69 G.H5 M 379 G.H5.24
Hydrophobic C-term L 591 - H.HA L 115 H.HA.29
Van-der-waals C-term L 591 - H.HA L 115 H.HA.29
Hydrophobic TM4 A 350 4x37 G.h2s4 D 243 G.h2s4.02
Hydrophobic TM5 I 427 5x72 G.H5 I 378 G.H5.23
Van-der-waals TM5 I 427 5x72 G.H5 I 378 G.H5.23
Hydrophobic C-term P 588 - H.HA V 107 H.HA.21
Hydrophobic TM4 A 353 4x40 G.h2s4 D 243 G.h2s4.02
Van-der-waals TM4 A 353 4x40 G.h2s4 D 243 G.h2s4.02
Hydrophobic TM5 L 424 5x69 G.H5 I 378 G.H5.23
Van-der-waals TM5 L 424 5x69 G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 441 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 441 - G.H5 L 375 G.H5.20
Polar TM6 M 445 6x30 G.H5 M 379 G.H5.24
Hydrophobic TM6 M 445 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 445 6x30 G.H5 M 379 G.H5.24
Hydrophobic TM5 M 431 5x76 G.H5 L 375 G.H5.20
Van-der-waals TM5 M 431 5x76 G.H5 L 375 G.H5.20
Polar ICL3 N 437 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 N 437 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 N 437 - G.H5 Q 372 G.H5.17
Hydrophobic TM6 I 448 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM4 H 348 4x35 G.h3s5 N 288 G.h3s5.02
Polar ICL2 K 345 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 345 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 345 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 430 5x75 G.H5 L 371 G.H5.16
Hydrophobic TM3 G 343 3x55 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 G 343 3x55 G.hns1 R 55 G.hns1.02
Polar TM4 G 347 4x34 G.h2s4 I 245 G.h2s4.04
Hydrophobic TM4 G 347 4x34 G.h2s4 I 245 G.h2s4.04
Van-der-waals TM4 G 347 4x34 G.h2s4 I 245 G.h2s4.04
Polar ICL3 T 436 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 T 436 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 T 436 - G.H5 Q 372 G.H5.17
Hydrophobic C-term L 591 - H.HD E 172 H.HD.12
Polar C-term P 588 - H.HA D 110 H.HA.24
Hydrophobic C-term P 588 - H.HA D 110 H.HA.24
Van-der-waals C-term P 588 - H.HA D 110 H.HA.24
Polar C-term N 587 - H.HA K 114 H.HA.28
Hydrophobic C-term N 587 - H.HA K 114 H.HA.28
Van-der-waals C-term N 587 - H.HA K 114 H.HA.28
Polar TM5 H 426 5x71 G.hns1 R 56 G.hns1.03
Aromatic TM5 H 426 5x71 G.hns1 R 56 G.hns1.03
Van-der-waals TM5 H 426 5x71 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 345 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 K 345 - G.H5 I 378 G.H5.23
Polar C-term T 589 - H.HA D 110 H.HA.24
Hydrophobic C-term T 589 - H.HA D 110 H.HA.24
Van-der-waals C-term T 589 - H.HA D 110 H.HA.24
Hydrophobic ICL2 K 345 - G.S1 L 57 G.S1.01
Van-der-waals ICL2 K 345 - G.S1 L 57 G.S1.01
Hydrophobic TM3 A 341 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 341 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 448 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 I 448 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM4 E 349 4x36 G.h2s4 D 243 G.h2s4.02
Van-der-waals TM4 E 349 4x36 G.h2s4 D 243 G.h2s4.02
Hydrophobic TM5 R 428 5x73 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 444 6x29 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 444 6x29 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 441 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 L 441 - G.H5 K 376 G.H5.21
Hydrophobic C-term L 576 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 576 - G.H2 Q 236 G.H2.05
Hydrophobic TM5 I 427 5x72 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 427 5x72 G.H5 L 375 G.H5.20
Polar ICL3 N 437 - G.H5 K 376 G.H5.21
Hydrophobic ICL3 N 437 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 N 437 - G.H5 K 376 G.H5.21
Hydrophobic C-term L 591 - H.hdhe F 173 H.hdhe.01
Polar ICL1 H 258 12x48 G.H3 K 284 G.H3.16
Aromatic ICL1 H 258 12x48 G.H3 K 284 G.H3.16
Hydrophobic ICL1 H 258 12x48 G.H3 K 284 G.H3.16
Van-der-waals ICL1 H 258 12x48 G.H3 K 284 G.H3.16
Polar TM3 A 342 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 342 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 342 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 W 346 - G.h2s4 G 244 G.h2s4.03
Hydrophobic TM3 A 341 3x53 G.H5 Q 381 G.H5.26
Van-der-waals TM3 A 341 3x53 G.H5 Q 381 G.H5.26
Van-der-waals C-term L 591 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM6 I 448 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 448 6x33 G.H5 M 379 G.H5.24
Polar C-term T 589 - H.HA V 107 H.HA.21
Hydrophobic C-term T 589 - H.HA V 107 H.HA.21
Van-der-waals C-term T 589 - H.HA V 107 H.HA.21
Polar TM2 Y 262 2x39 G.h3s5 N 288 G.h3s5.02
Hydrophobic C-term M 578 - G.H2 Q 236 G.H2.05
Polar TM2 Y 262 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 Y 262 2x39 G.H5 Q 381 G.H5.26
Hydrophobic TM5 R 428 5x73 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 428 5x73 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 444 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 L 444 6x29 G.H5 K 376 G.H5.21
Polar C-term T 589 - H.HA A 111 H.HA.25
Hydrophobic C-term T 589 - H.HA A 111 H.HA.25
Van-der-waals C-term T 589 - H.HA A 111 H.HA.25
Polar TM4 H 348 4x35 G.H3 L 285 G.H3.17
Hydrophobic TM4 H 348 4x35 G.H3 L 285 G.H3.17
Van-der-waals TM4 H 348 4x35 G.H3 L 285 G.H3.17
Polar ICL2 K 345 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 345 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 345 - G.hns1 R 55 G.hns1.02
Polar C-term H 590 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term H 590 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term H 590 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM5 I 430 5x75 G.S3 I 221 G.S3.01
Hydrophobic TM4 E 349 4x36 G.H3 L 285 G.H3.17
Van-der-waals TM4 E 349 4x36 G.H3 L 285 G.H3.17
Hydrophobic C-term P 588 - H.HB M 132 H.HB.10
Polar ICL2 K 345 - G.h2s4 T 246 G.h2s4.05
Hydrophobic TM6 L 444 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 444 6x29 G.H5 M 379 G.H5.24
Van-der-waals ICL2 W 346 - G.H5 Q 381 G.H5.26
Hydrophobic ICL2 K 345 - G.S1 V 58 G.S1.02
Hydrophobic TM4 E 349 4x36 G.H3 F 286 G.H3.18
Van-der-waals TM4 E 349 4x36 G.H3 F 286 G.H3.18
Polar ICL2 K 344 - G.HN R 51 G.HN.51
Van-der-waals ICL2 K 344 - G.HN R 51 G.HN.51
Hydrophobic TM4 H 348 4x35 G.h3s5 V 289 G.h3s5.03
Van-der-waals TM4 H 348 4x35 G.h3s5 V 289 G.h3s5.03
Polar H8 K 532 8x49 G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 K 532 8x49 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 K 532 8x49 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM2 P 263 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 P 263 2x40 G.H5 Q 381 G.H5.26
Hydrophobic C-term N 587 - H.HA D 110 H.HA.24
Van-der-waals C-term N 587 - H.HA D 110 H.HA.24
Polar TM3 F 339 3x51 G.hns1 R 55 G.hns1.02
Aromatic TM3 F 339 3x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 F 339 3x51 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 F 339 3x51 G.hns1 R 55 G.hns1.02
Polar C-term T 589 - H.HA K 114 H.HA.28
Hydrophobic C-term T 589 - H.HA K 114 H.HA.28
Van-der-waals C-term T 589 - H.HA K 114 H.HA.28
Polar TM3 W 338 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM3 W 338 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 W 338 3x50 G.H5 Q 381 G.H5.26
Van-der-waals ICL2 K 344 - G.hns1 V 54 G.hns1.01
Polar ICL1 Q 261 12x51 G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL1 Q 261 12x51 G.h3s5 F 287 G.h3s5.01
Van-der-waals ICL1 Q 261 12x51 G.h3s5 F 287 G.h3s5.01
Polar TM4 G 347 4x34 G.h2s4 G 244 G.h2s4.03
Hydrophobic TM4 G 347 4x34 G.h2s4 G 244 G.h2s4.03
Van-der-waals TM4 G 347 4x34 G.h2s4 G 244 G.h2s4.03
Polar ICL1 Q 261 12x51 G.H3 K 284 G.H3.16
Hydrophobic ICL1 Q 261 12x51 G.H3 K 284 G.H3.16
Van-der-waals ICL1 Q 261 12x51 G.H3 K 284 G.H3.16
Hydrophobic TM4 A 350 4x37 G.h2s4 G 244 G.h2s4.03
Van-der-waals TM4 A 350 4x37 G.h2s4 G 244 G.h2s4.03
Hydrophobic TM4 E 349 4x36 G.h2s4 F 242 G.h2s4.01
Van-der-waals TM4 E 349 4x36 G.h2s4 F 242 G.h2s4.01
Hydrophobic ICL3 T 436 - G.H5 D 368 G.H5.13
Hydrophobic TM5 M 431 5x76 G.H5 Q 372 G.H5.17
Van-der-waals TM5 M 431 5x76 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 441 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 L 441 - G.H5 M 379 G.H5.24
Hydrophobic ICL3 K 440 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 K 440 - G.H5 K 376 G.H5.21