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ghrelin receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 88.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | L | 239 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | K | 152 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 152 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | A | 358 | - | G.H3 | M | 249 | G.H3.07 |
Ionic | C-term | E | 361 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | E | 361 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | E | 361 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | E | 361 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | D | 353 | - | G.H3 | K | 258 | G.H3.16 |
Polar | C-term | D | 353 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM6 | M | 264 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | M | 264 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | W | 359 | - | G.H2 | R | 209 | G.H2.04 |
Aromatic | C-term | W | 359 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | W | 359 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | W | 359 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Ionic | TM5 | R | 242 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 242 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 242 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 242 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | S | 362 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | S | 362 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | S | 362 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | W | 359 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | W | 359 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | T | 360 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | W | 359 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | W | 359 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM4 | T | 156 | 4x38 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | H | 258 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | T | 261 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | T | 261 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | I | 364 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | I | 364 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | L | 239 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | T | 261 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 261 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 261 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | M | 264 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 264 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | W | 359 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | W | 359 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | W | 359 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM2 | T | 78 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | L | 265 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | A | 358 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | K | 238 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM7 | M | 326 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | M | 326 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM5 | D | 246 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | I | 364 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | I | 364 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | I | 364 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM2 | T | 78 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 78 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Polar | TM6 | N | 257 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | N | 257 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 257 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | A | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | TM5 | R | 242 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 242 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | R | 242 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM7 | M | 326 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM7 | M | 326 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | E | 361 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM6 | L | 253 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | L | 253 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM5 | R | 242 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 242 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | K | 152 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | K | 152 | 34x54 | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.S1 | D | 33 | G.S1.01 |
Van-der-waals | ICL2 | K | 152 | 34x54 | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | V | 153 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | TM6 | R | 254 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | W | 359 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.S3 | L | 195 | G.S3.01 |