Gs - ghrelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 149 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM6 M 264 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM4 T 156 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 V 153 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 V 153 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 V 153 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 N 257 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM5 K 238 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 151 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 149 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 M 264 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 M 264 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 149 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 149 34x51 G.H5 F 376 G.H5.08
Polar TM3 A 144 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 H 387 G.H5.19
Polar C-term W 359 - G.H3 S 275 G.H3.11
Hydrophobic C-term W 359 - G.H3 S 275 G.H3.11
Van-der-waals C-term W 359 - G.H3 S 275 G.H3.11
Hydrophobic ICL3 V 248 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 V 248 - G.S6 P 361 G.S6.03
Hydrophobic ICL2 P 148 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 L 137 3x46 G.H5 Y 391 G.H5.23
Ionic TM6 R 254 6x26 G.H5 D 381 G.H5.13
Polar TM6 R 254 6x26 G.H5 D 381 G.H5.13
Hydrophobic TM3 R 141 3x50 G.H5 L 393 G.H5.25
Polar TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 145 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 393 G.H5.25
Polar TM6 T 261 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 261 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 261 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 V 249 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 V 249 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 P 148 34x50 G.H5 R 380 G.H5.12
Polar TM3 I 145 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 145 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 265 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Polar TM5 R 242 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 242 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 242 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM7 M 326 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 145 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 149 34x51 G.S1 H 41 G.S1.02
Polar ICL2 K 152 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 152 34x54 G.S1 H 41 G.S1.02
Van-der-waals TM7 Y 323 7x53 G.H5 E 392 G.H5.24
Polar TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 148 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 148 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 149 34x51 G.H5 R 380 G.H5.12
Polar TM2 T 77 2x38 G.H5 Q 390 G.H5.22
Ionic TM5 R 242 5x68 G.H5 D 381 G.H5.13
Polar TM5 R 242 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 242 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 242 5x68 G.H5 D 381 G.H5.13
Polar TM6 R 254 6x26 G.S6 Y 360 G.S6.02
Hydrophobic TM6 R 254 6x26 G.S6 Y 360 G.S6.02
Van-der-waals TM6 R 254 6x26 G.S6 Y 360 G.S6.02
Hydrophobic TM5 L 239 5x65 G.H5 Q 384 G.H5.16
Polar H8 S 327 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 327 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 327 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 261 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL3 V 249 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 V 249 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 P 148 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 239 5x65 G.H5 L 388 G.H5.20
Polar TM2 T 77 2x38 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 254 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 254 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM5 R 242 5x68 G.H5 R 380 G.H5.12