Gs - glucagon receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 328 5x60 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 257 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 T 257 - G.S1 H 41 G.S1.02
Hydrophobic TM6 T 353 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 252 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 252 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL3 M 338 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 M 338 - G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 K 332 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Polar TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Polar ICL2 A 256 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 256 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 A 256 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 258 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 257 - G.hns1 A 39 G.hns1.03
Ionic TM5 K 332 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 332 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 332 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 332 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 258 - G.H5 M 386 G.H5.18
Hydrophobic TM3 L 252 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 333 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 329 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 253 3x58 G.H5 H 387 G.H5.19
Polar TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 E 260 - G.hns1 A 39 G.hns1.03
Polar ICL3 Q 337 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 Q 337 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 Q 337 - G.S6 Y 360 G.S6.02
Hydrophobic H8 N 404 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 E 260 - G.HN Q 35 G.HN.52
Polar ICL2 R 261 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 R 261 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 A 256 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 256 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 A 256 - G.S3 V 217 G.S3.01
Hydrophobic TM6 L 354 6x45 G.H5 L 393 G.H5.25
Polar ICL3 Q 337 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 Q 337 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 337 - G.S6 C 359 G.S6.01
Hydrophobic ICL2 T 257 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 A 256 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 M 338 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 338 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 E 245 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 245 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 253 3x58 G.H5 L 388 G.H5.20
Ionic ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM7 Y 400 7x57 G.H5 Y 391 G.H5.23
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 Q 337 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 337 - G.h4s6 Y 358 G.h4s6.20
Polar ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 258 - G.hns1 R 38 G.hns1.02
Polar TM6 S 350 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 350 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 350 6x41 G.H5 L 393 G.H5.25
Ionic H8 K 405 8x48 G.H5 E 392 G.H5.24
Polar H8 K 405 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 405 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 357 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 329 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 329 5x61 G.H5 L 393 G.H5.25
Polar ICL3 Q 337 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 Q 337 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 256 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 T 257 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 257 - G.S3 V 217 G.S3.01
Hydrophobic TM3 Y 248 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 248 3x53 G.H5 Y 391 G.H5.23
Polar TM5 K 332 5x64 G.H5 R 385 G.H5.17