Gs - GPR174 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 123 34x50 G.H5 Q 384 G.H5.16
Aromatic ICL1 R 53 - G.H5 Y 391 G.H5.23
Hydrophobic ICL1 R 53 - G.H5 Y 391 G.H5.23
Polar ICL2 H 127 34x54 G.H5 Y 391 G.H5.23
Polar TM1 Y 47 1x60 G.H5 E 392 G.H5.24
Hydrophobic TM1 Y 47 1x60 G.H5 E 392 G.H5.24
Van-der-waals TM1 Y 47 1x60 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 124 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 124 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 124 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 124 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 H 127 34x54 G.H5 I 383 G.H5.15
Van-der-waals ICL2 H 127 34x54 G.H5 I 383 G.H5.15
Hydrophobic TM6 M 231 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 231 6x36 G.H5 L 393 G.H5.25
Ionic ICL3 D 221 - G.H5 R 385 G.H5.17
Polar ICL3 D 221 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 D 221 - G.H5 R 385 G.H5.17
Polar TM6 K 225 6x30 G.H5 Q 384 G.H5.16
Ionic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar TM6 K 225 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar H8 N 297 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 N 297 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 N 297 8x48 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 123 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 123 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 L 212 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 E 224 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 E 224 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 A 228 6x33 G.H5 L 393 G.H5.25
Polar TM3 F 119 3x53 G.H5 H 387 G.H5.19
Aromatic TM3 F 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 F 119 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 F 119 3x53 G.H5 H 387 G.H5.19
Ionic ICL2 D 128 34x55 G.hns1 R 38 G.hns1.02
Polar ICL2 D 128 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 D 128 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 D 128 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 M 218 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 M 218 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 L 222 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 L 222 - G.h4s6 G 355 G.h4s6.11
Aromatic ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 L 212 5x65 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 124 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL3 L 222 - G.h4s6 Y 358 G.h4s6.20
Polar TM5 S 211 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 211 5x64 G.H5 Q 384 G.H5.16
Polar H8 T 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 T 296 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 120 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 120 3x54 G.H5 L 388 G.H5.20
Polar ICL3 Y 216 - G.H5 N 377 G.H5.09
Hydrophobic ICL3 Y 216 - G.H5 N 377 G.H5.09
Van-der-waals ICL3 Y 216 - G.H5 N 377 G.H5.09
Aromatic ICL2 F 124 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 124 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 124 34x51 G.H5 F 376 G.H5.08
Polar ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 Q 390 G.H5.22
Polar H8 F 299 8x50 G.H5 E 392 G.H5.24
Hydrophobic ICL3 A 219 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 A 219 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 123 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 123 34x50 G.H5 R 380 G.H5.12
Polar ICL2 C 129 34x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 C 129 34x56 G.H5 Y 391 G.H5.23
Polar TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 120 3x54 G.H5 L 393 G.H5.25
Polar TM1 Y 47 1x60 G.H5 Q 390 G.H5.22
Hydrophobic TM6 K 225 6x30 G.H5 R 385 G.H5.17
Polar ICL2 H 127 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 H 127 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 H 127 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 H 127 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 124 34x51 G.S3 F 219 G.S3.03
Hydrophobic H8 E 298 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 E 298 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 116 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 116 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL3 Y 216 - G.H5 D 381 G.H5.13
Polar TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic H8 T 296 8x47 G.H5 L 394 G.H5.26
Polar ICL2 H 127 34x54 G.H5 H 387 G.H5.19
Aromatic ICL2 H 127 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 127 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL3 M 218 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 M 218 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 F 124 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 124 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 218 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 Q 220 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 Q 220 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL1 A 54 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 A 54 - G.H5 Y 391 G.H5.23
Polar ICL3 Q 220 - G.h4s6 S 349 G.h4s6.02
Hydrophobic ICL3 Q 220 - G.h4s6 S 349 G.h4s6.02
Van-der-waals ICL3 Q 220 - G.h4s6 S 349 G.h4s6.02
Polar ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 L 222 - G.h4s6 D 354 G.h4s6.10
Hydrophobic TM6 K 227 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 227 6x32 G.H5 L 394 G.H5.26
Polar ICL3 Y 216 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 M 218 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 M 218 - G.H5 R 385 G.H5.17
Hydrophobic TM6 A 228 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 228 6x33 G.H5 L 388 G.H5.20
Aromatic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 F 119 3x53 G.H5 Y 391 G.H5.23