G12 - GPR183 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 136 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 K 141 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 141 34x55 G.hns1 R 56 G.hns1.03
Ionic TM4 E 146 4x40 G.HN R 52 G.HN.52
Polar TM4 E 146 4x40 G.HN R 52 G.HN.52
Polar H8 C 312 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 C 312 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 C 312 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM5 T 226 5x68 G.H5 L 371 G.H5.16
Polar TM3 R 129 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 242 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 242 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 133 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 133 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 K 241 6x32 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 136 34x50 G.H5 I 370 G.H5.15
Polar TM3 A 132 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 132 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 132 3x53 G.H5 N 374 G.H5.19
Polar H8 K 313 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 313 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 Y 315 8x50 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 Y 139 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 N 230 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 N 230 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM6 V 238 6x29 G.H5 K 376 G.H5.21
Polar TM6 N 239 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM3 V 133 3x54 G.H5 M 379 G.H5.24
Polar H8 C 312 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 C 312 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 C 312 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 137 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 137 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 232 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 136 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 K 222 5x64 G.H5 L 371 G.H5.16
Hydrophobic H8 G 314 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 G 314 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM5 I 219 5x61 G.H5 M 379 G.H5.24
Polar TM5 N 230 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 N 230 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM3 R 129 3x50 G.H5 M 379 G.H5.24
Polar H8 C 312 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 C 312 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM4 R 144 4x38 G.HN R 52 G.HN.52
Hydrophobic TM6 V 238 6x29 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 137 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM2 T 66 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 T 66 2x39 G.H5 I 378 G.H5.23
Polar TM5 Q 229 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL2 L 137 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 L 223 5x65 G.H5 M 379 G.H5.24
Ionic ICL2 K 143 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM6 I 246 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL2 Y 139 34x53 G.H5 I 378 G.H5.23
Van-der-waals ICL2 Y 139 34x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 137 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 137 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL3 T 233 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 A 242 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 223 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 223 5x65 G.H5 L 375 G.H5.20
Polar H8 G 314 8x49 G.H5 L 380 G.H5.25
Van-der-waals TM4 R 144 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 T 226 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 T 226 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 A 132 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 132 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 137 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 137 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 V 238 6x29 G.H5 L 380 G.H5.25
Hydrophobic ICL3 T 233 - G.H5 Q 372 G.H5.17
Hydrophobic TM3 V 133 3x54 G.H5 L 375 G.H5.20