Gi2 - mGlu6 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 L 858 8x57 G.H5 D 342 G.H5.13
Hydrophobic H8 L 858 8x57 G.H5 D 342 G.H5.13
Van-der-waals H8 L 858 8x57 G.H5 D 342 G.H5.13
Hydrophobic ICL2 G 682 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 T 687 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 686 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 V 686 - G.S1 V 34 G.S1.02
Polar ICL2 P 688 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 688 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 688 - G.H5 N 348 G.H5.19
Hydrophobic TM3 F 679 3x58 G.H5 I 345 G.H5.16
Van-der-waals TM3 F 679 3x58 G.H5 I 345 G.H5.16
Polar TM3 R 674 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 674 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 674 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL1 S 619 12x53 G.H5 L 354 G.H5.25
Van-der-waals ICL1 R 617 12x51 G.H5 G 353 G.H5.24
Hydrophobic TM2 G 620 2x35 G.H5 L 354 G.H5.25
Van-der-waals TM2 G 620 2x35 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 678 3x57 G.H5 L 349 G.H5.20
Ionic H8 R 854 8x53 G.h4s6 D 316 G.h4s6.09
Polar H8 R 854 8x53 G.h4s6 D 316 G.h4s6.09
Hydrophobic H8 R 854 8x53 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL2 S 685 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 S 685 - G.S3 L 195 G.S3.01
Hydrophobic TM3 R 674 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 674 3x53 G.H5 L 354 G.H5.25
Hydrophobic ICL1 A 618 12x52 G.H5 L 354 G.H5.25
Van-der-waals ICL1 A 618 12x52 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 678 3x57 G.H5 N 348 G.H5.19
Polar H8 R 854 8x53 G.h4s6 K 315 G.h4s6.08
Hydrophobic H8 R 854 8x53 G.h4s6 K 315 G.h4s6.08
Van-der-waals H8 R 854 8x53 G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL2 K 683 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 K 683 - G.H5 F 337 G.H5.08
Hydrophobic ICL2 R 684 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 684 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 I 692 - G.H5 C 352 G.H5.23
Hydrophobic ICL2 K 683 - G.S3 L 195 G.S3.01
Hydrophobic ICL1 R 617 12x51 G.H5 L 354 G.H5.25
Hydrophobic TM6 F 779 6x33 G.H5 F 355 G.H5.26
Van-der-waals H8 R 856 8x55 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 F 679 3x58 G.H5 L 349 G.H5.20
Hydrophobic ICL2 V 686 - G.H5 I 344 G.H5.15
Polar H8 S 857 8x56 G.h4s6 E 319 G.h4s6.12
Van-der-waals H8 S 857 8x56 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 V 686 - G.S1 E 33 G.S1.01
Hydrophobic H8 Q 852 8x51 G.H5 F 355 G.H5.26
Van-der-waals H8 Q 852 8x51 G.H5 F 355 G.H5.26
Hydrophobic ICL2 V 686 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 K 683 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 G 682 - G.H5 I 345 G.H5.16
Hydrophobic TM3 I 678 3x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 T 687 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 687 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 G 682 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 G 682 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 V 686 - G.hns1 R 32 G.hns1.03
Ionic C-term K 859 - G.H5 D 338 G.H5.09
Polar C-term K 859 - G.H5 D 338 G.H5.09
Hydrophobic C-term K 859 - G.H5 D 338 G.H5.09
Van-der-waals C-term K 859 - G.H5 D 338 G.H5.09
Hydrophobic TM6 F 779 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 F 779 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL1 R 617 12x51 G.H5 F 355 G.H5.26
Van-der-waals C-term K 859 - G.H5 Q 334 G.H5.05