Go - HCA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term G 359 - H.HA Q 68 H.HA.06
Hydrophobic C-term M 346 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term M 346 - G.s4h3 D 238 G.s4h3.11
Polar C-term S 354 - H.hbhc D 116 H.hbhc.04
Polar C-term W 353 - H.HA Q 79 H.HA.17
Hydrophobic C-term W 353 - H.HA Q 79 H.HA.17
Van-der-waals C-term W 353 - H.HA Q 79 H.HA.17
Polar TM6 K 225 6x29 G.h4s6 N 316 G.h4s6.10
Van-der-waals TM6 K 225 6x29 G.h4s6 N 316 G.h4s6.10
Hydrophobic C-term S 354 - H.hbhc M 114 H.hbhc.02
Van-der-waals C-term S 354 - H.hbhc M 114 H.hbhc.02
Polar ICL2 K 138 34x56 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 138 34x56 G.hns1 A 31 G.hns1.02
Hydrophobic C-term W 353 - H.HA S 75 H.HA.13
Van-der-waals C-term W 353 - H.HA S 75 H.HA.13
Polar C-term M 346 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term M 346 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term M 346 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 H 133 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 H 133 34x51 G.S3 L 195 G.S3.01
Hydrophobic H8 P 299 8x48 G.H5 G 352 G.H5.24
Ionic C-term E 351 - H.HA R 86 H.HA.24
Polar C-term E 351 - H.HA R 86 H.HA.24
Hydrophobic C-term E 351 - H.HA R 86 H.HA.24
Van-der-waals C-term E 351 - H.HA R 86 H.HA.24
Hydrophobic C-term S 356 - H.hbhc T 117 H.hbhc.05
Van-der-waals C-term S 356 - H.hbhc T 117 H.hbhc.05
Polar TM6 K 225 6x29 G.h4s6 P 315 G.h4s6.09
Van-der-waals TM6 K 225 6x29 G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL2 P 132 34x50 G.H5 I 343 G.H5.15
Hydrophobic C-term T 361 - H.HA E 64 H.HA.02
Van-der-waals C-term T 361 - H.HA E 64 H.HA.02
Hydrophobic ICL2 H 133 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 133 34x51 G.H5 I 343 G.H5.15
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 347 G.H5.19
Polar ICL2 H 133 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 133 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL3 M 220 - G.H5 A 345 G.H5.17
Hydrophobic C-term P 352 - H.hbhc M 114 H.hbhc.02
Van-der-waals C-term P 352 - H.hbhc M 114 H.hbhc.02
Hydrophobic C-term Y 357 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term L 358 - H.HA Q 68 H.HA.06
Van-der-waals C-term L 358 - H.HA Q 68 H.HA.06
Hydrophobic TM5 R 218 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 T 340 G.H5.12
Polar C-term W 353 - H.hbhc D 116 H.hbhc.04
Hydrophobic C-term W 353 - H.hbhc D 116 H.hbhc.04
Van-der-waals C-term W 353 - H.hbhc D 116 H.hbhc.04
Hydrophobic TM6 K 225 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 I 226 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Polar ICL2 K 138 34x56 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 138 34x56 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 138 34x56 G.hns1 K 32 G.hns1.03
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 220 - G.H5 I 344 G.H5.16
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Ionic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 215 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 125 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 220 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 220 - G.H5 D 341 G.H5.13
Hydrophobic H8 P 299 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 P 299 8x48 G.H5 Y 354 G.H5.26
Polar TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 232 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 232 6x36 G.H5 L 353 G.H5.25
Polar C-term N 348 - G.s4h3 H 236 G.s4h3.09
Hydrophobic C-term N 348 - G.s4h3 H 236 G.s4h3.09
Van-der-waals C-term N 348 - G.s4h3 H 236 G.s4h3.09
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic C-term L 358 - H.HA V 72 H.HA.10
Hydrophobic ICL2 P 132 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 C 351 G.H5.23
Polar H8 S 298 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 298 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 298 8x47 G.H5 G 352 G.H5.24
Hydrophobic C-term A 347 - G.H2 R 206 G.H2.01
Van-der-waals C-term A 347 - G.H2 R 206 G.H2.01
Polar TM5 R 218 5x68 G.H5 D 337 G.H5.09
Hydrophobic TM5 L 215 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 132 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 132 34x50 G.H5 T 340 G.H5.12
Polar TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic C-term L 345 - G.s4h3 E 237 G.s4h3.10
Polar C-term T 361 - H.HA Q 68 H.HA.06
Van-der-waals C-term T 361 - H.HA Q 68 H.HA.06
Hydrophobic TM3 V 129 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 I 344 G.H5.16
Hydrophobic C-term L 345 - G.H2 R 209 G.H2.04