G11 -
HCA3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | K | 138 | 34x56 | G.S1 | E | 39 | G.S1.01 |
Hydrophobic | C-term | L | 382 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | L | 382 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | G | 383 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | G | 383 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | L | 382 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Polar | TM3 | R | 128 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | R | 128 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | R | 128 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM6 | K | 225 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | K | 225 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 225 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM2 | K | 60 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | K | 60 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | K | 60 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | K | 60 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | H8 | P | 302 | 8x51 | G.H5 | N | 357 | G.H5.24 |
Polar | TM2 | S | 62 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | L | 378 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | L | 378 | - | G.H3 | L | 254 | G.H3.08 |
Polar | TM3 | R | 128 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 128 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 128 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | L | 215 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Polar | ICL2 | K | 138 | 34x56 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | K | 138 | 34x56 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | K | 138 | 34x56 | G.hns1 | R | 38 | G.hns1.03 |
Ionic | TM3 | R | 128 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | R | 128 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM3 | R | 128 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM7 | S | 297 | 7x56 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | L | 378 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | L | 378 | - | G.H3 | A | 253 | G.H3.07 |
Polar | C-term | E | 379 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | C-term | G | 383 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | C-term | Q | 381 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | Q | 381 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | Q | 381 | - | G.H2 | R | 214 | G.H2.05 |
Polar | ICL2 | K | 138 | 34x56 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | K | 138 | 34x56 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | K | 138 | 34x56 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | C-term | L | 382 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | L | 382 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL2 | H | 133 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | H | 133 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | P | 299 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | L | 382 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL2 | H | 133 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | H | 133 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | L | 382 | - | G.H3 | I | 258 | G.H3.12 |
Hydrophobic | C-term | C | 384 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM6 | I | 226 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | L | 382 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 382 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 382 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | H8 | S | 298 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | C | 384 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | C | 384 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | C | 384 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | I | 233 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Polar | TM7 | F | 296 | 7x55 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | F | 296 | 7x55 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | F | 296 | 7x55 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | Q | 381 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | V | 129 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM6 | I | 226 | 6x30 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | I | 226 | 6x30 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | A | 229 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 229 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | R | 218 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | R | 218 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM7 | S | 297 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | E | 379 | - | G.H3 | T | 257 | G.H3.11 |
Polar | TM3 | D | 124 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | D | 124 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | D | 124 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM7 | Y | 295 | 7x54 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | Q | 381 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | Q | 381 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | Q | 381 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL3 | M | 220 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | M | 220 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | M | 220 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL3 | M | 220 | - | G.H5 | Q | 350 | G.H5.17 |
Polar | TM2 | S | 62 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | S | 62 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | S | 62 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | H | 133 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | H | 133 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Polar | TM6 | I | 226 | 6x30 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | L | 382 | - | G.H2 | W | 216 | G.H2.07 |
Polar | C-term | C | 384 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | C | 384 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | C | 384 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM3 | R | 125 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 125 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | P | 299 | 8x48 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | P | 299 | 8x48 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | M | 220 | - | G.H5 | L | 353 | G.H5.20 |