G15 - BLT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 213 - G.H5 L 368 G.H5.20
Polar TM7 G 289 7x57 G.H5 N 372 G.H5.24
Hydrophobic TM7 G 289 7x57 G.H5 N 372 G.H5.24
Van-der-waals TM7 G 289 7x57 G.H5 N 372 G.H5.24
Polar TM3 R 115 3x50 G.H5 Y 367 G.H5.19
Hydrophobic TM3 R 115 3x50 G.H5 Y 367 G.H5.19
Van-der-waals TM3 R 115 3x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 129 34x57 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 129 34x57 G.H5 Y 367 G.H5.19
Aromatic ICL2 F 123 34x51 G.H5 F 356 G.H5.08
Hydrophobic ICL2 F 123 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 F 123 34x51 G.H5 F 356 G.H5.08
Hydrophobic TM6 L 222 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM3 A 118 3x53 G.H5 L 364 G.H5.16
Hydrophobic ICL2 P 122 34x50 G.H5 R 360 G.H5.12
Hydrophobic ICL2 Q 126 34x54 G.H5 V 363 G.H5.15
Polar C-term N 349 - G.HG H 290 G.HG.14
Hydrophobic TM6 S 216 6x30 G.H5 L 374 G.H5.26
Van-der-waals TM6 S 216 6x30 G.H5 L 374 G.H5.26
Hydrophobic TM7 G 289 7x57 G.H5 I 371 G.H5.23
Van-der-waals TM7 G 289 7x57 G.H5 I 371 G.H5.23
Polar C-term N 349 - G.HG T 288 G.HG.12
Hydrophobic C-term N 349 - G.HG T 288 G.HG.12
Van-der-waals C-term N 349 - G.HG T 288 G.HG.12
Hydrophobic TM3 V 119 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM3 A 118 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM4 T 130 4x38 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 T 130 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 F 123 34x51 G.H5 V 363 G.H5.15
Ionic TM5 R 211 5x68 G.H5 D 361 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 361 G.H5.13
Hydrophobic TM5 R 211 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 361 G.H5.13
Polar TM6 T 219 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 T 219 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 219 6x33 G.H5 L 373 G.H5.25
Hydrophobic ICL2 F 123 34x51 G.H5 R 360 G.H5.12
Van-der-waals ICL2 F 123 34x51 G.H5 R 360 G.H5.12
Polar TM7 G 291 7x59 G.H5 N 372 G.H5.24
Van-der-waals TM7 G 291 7x59 G.H5 N 372 G.H5.24
Polar TM2 T 53 2x39 G.H5 E 370 G.H5.22
Aromatic ICL3 F 213 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 F 213 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 F 213 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 R 211 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 R 211 5x68 G.H5 L 364 G.H5.16
Polar TM3 D 114 3x49 G.H5 Y 367 G.H5.19
Hydrophobic TM3 D 114 3x49 G.H5 Y 367 G.H5.19
Van-der-waals TM3 D 114 3x49 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Q 126 34x54 G.h2s4 I 227 G.h2s4.05
Van-der-waals ICL2 Q 126 34x54 G.h2s4 I 227 G.h2s4.05
Hydrophobic ICL2 P 122 34x50 G.H5 V 363 G.H5.15
Polar C-term E 350 - G.H4 Q 303 G.H4.02
Van-der-waals C-term E 350 - G.H4 Q 303 G.H4.02
Hydrophobic ICL3 F 213 - G.H5 A 365 G.H5.17
Hydrophobic ICL2 Q 126 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 Q 126 34x54 G.S1 L 43 G.S1.02
Polar TM7 A 288 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 A 288 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM7 G 290 7x58 G.H5 N 372 G.H5.24
Van-der-waals TM7 G 290 7x58 G.H5 N 372 G.H5.24
Polar TM5 R 211 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM5 R 211 5x68 G.H5 R 360 G.H5.12
Van-der-waals TM5 R 211 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM5 L 208 5x65 G.H5 L 364 G.H5.16
Hydrophobic TM5 L 208 5x65 G.H5 L 368 G.H5.20
Hydrophobic TM3 R 115 3x50 G.H5 I 371 G.H5.23
Hydrophobic ICL2 F 123 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 F 123 34x51 G.S1 L 43 G.S1.02
Ionic ICL2 R 129 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 129 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 129 34x57 G.H5 E 370 G.H5.22
Hydrophobic ICL3 F 213 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 F 213 - G.H5 D 361 G.H5.13
Polar C-term N 349 - G.HG P 287 G.HG.09
Hydrophobic ICL2 P 122 34x50 G.H5 L 364 G.H5.16
Hydrophobic ICL2 F 123 34x51 G.H5 V 359 G.H5.11
Hydrophobic ICL2 F 123 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL3 F 213 - G.H5 L 364 G.H5.16