Gz - MC3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 149 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 L 354 G.H5.25
Polar TM2 Y 74 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM2 Y 74 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 Y 74 2x40 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 150 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 150 34x51 G.S1 I 34 G.S1.02
Hydrophobic TM5 A 214 5x65 G.H5 L 354 G.H5.25
Hydrophobic ICL2 S 154 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 224 - G.S6 Y 321 G.S6.02
Ionic TM5 H 217 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 217 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 217 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 217 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 V 218 5x69 G.H5 C 355 G.H5.26
Van-der-waals TM5 V 218 5x69 G.H5 C 355 G.H5.26
Polar TM3 T 145 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 T 145 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 T 145 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 150 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 150 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 I 244 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 244 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 243 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL3 L 224 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 L 224 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 H 217 5x68 G.H5 Q 346 G.H5.17
Hydrophobic TM3 I 146 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 H 217 5x68 G.H5 I 345 G.H5.16
Polar TM7 R 302 7x56 G.H5 I 352 G.H5.23
Hydrophobic TM7 R 302 7x56 G.H5 I 352 G.H5.23
Van-der-waals TM7 R 302 7x56 G.H5 I 352 G.H5.23
Hydrophobic TM2 M 73 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 M 73 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM5 I 221 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 I 221 5x72 G.h4s6 E 319 G.h4s6.12
Ionic ICL3 D 228 - G.H4 R 306 G.H4.13
Polar ICL3 A 227 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 A 227 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 A 227 - G.H4 R 306 G.H4.13
Ionic ICL2 R 151 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 151 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 151 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 151 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 F 213 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 F 213 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM5 A 214 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 150 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 150 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM5 M 210 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL2 A 149 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 R 142 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL2 R 151 34x52 G.S3 L 195 G.S3.01
Polar TM6 T 243 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 243 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 243 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 K 239 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 C 355 G.H5.26
Hydrophobic ICL2 L 150 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 150 34x51 G.H5 I 344 G.H5.15
Polar H8 S 303 8x47 G.H5 Y 351 G.H5.22
Hydrophobic H8 S 303 8x47 G.H5 Y 351 G.H5.22
Van-der-waals H8 S 303 8x47 G.H5 Y 351 G.H5.22
Polar TM6 G 240 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 G 240 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 G 240 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 150 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 150 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 150 34x51 G.H5 V 340 G.H5.11
Polar ICL2 H 153 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 153 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 153 34x54 G.hns1 R 32 G.hns1.03
Polar TM7 R 302 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 R 302 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 R 302 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM5 I 221 5x72 G.H5 Q 346 G.H5.17
Polar ICL2 R 151 34x52 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 R 151 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM4 T 157 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 157 4x38 G.hns1 R 32 G.hns1.03
Aromatic ICL2 H 153 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 H 153 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 H 153 34x54 G.hns1 R 31 G.hns1.02