G12 - MC4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM7 R 305 7x56 G.H5 I 378 G.H5.23
Van-der-waals TM7 R 305 7x56 G.H5 I 378 G.H5.23
Polar ICL1 H 76 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 H 76 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 A 219 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 219 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 155 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 155 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 L 229 5x75 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 M 215 5x61 G.H5 I 378 G.H5.23
Polar TM3 F 152 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 155 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 155 34x51 G.H5 I 370 G.H5.15
Polar ICL2 Q 156 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM5 I 226 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 226 5x72 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 155 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 L 155 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 155 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 151 3x54 G.H5 L 375 G.H5.20
Polar TM3 T 150 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 T 150 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 T 150 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 151 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 151 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 155 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL3 T 232 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 T 232 - G.h4s6 K 344 G.h4s6.19
Polar TM6 A 239 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 239 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 A 239 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 T 232 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 232 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 K 242 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM4 T 162 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 162 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 H 222 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 222 5x68 G.H5 L 371 G.H5.16
Polar ICL2 H 158 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 158 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 158 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 226 5x72 G.h4s6 P 345 G.h4s6.20
Polar ICL3 G 231 - G.h4s6 R 339 G.h4s6.08
Polar ICL3 G 233 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 T 246 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 246 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL3 G 231 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 G 231 - G.H4 D 336 G.H4.16
Hydrophobic TM3 I 151 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 151 3x54 G.H5 I 378 G.H5.23
Polar TM6 G 243 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 G 243 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 243 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM7 R 305 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 R 305 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM5 H 222 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 155 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 155 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 A 154 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 P 230 - G.S6 H 348 G.S6.03
Hydrophobic TM5 L 229 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 229 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM3 R 147 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 I 378 G.H5.23
Ionic TM5 H 222 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 222 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 Q 156 34x52 G.S3 I 221 G.S3.01
Polar ICL2 H 158 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 158 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 158 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 H 222 5x68 G.H5 L 375 G.H5.20
Polar ICL2 N 159 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 159 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM3 T 150 3x53 G.H5 I 378 G.H5.23
Polar ICL2 N 159 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 159 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 159 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 223 5x69 G.H5 M 379 G.H5.24