Gq - NMU1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term L 398 - G.H3 Y 261 G.H3.15
Hydrophobic C-term L 398 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 398 - G.H3 Y 261 G.H3.15
Polar TM3 E 158 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 158 3x49 G.H5 Y 356 G.H5.23
Hydrophobic C-term L 389 - G.H3 P 262 G.H3.16
Van-der-waals C-term L 389 - G.H3 P 262 G.H3.16
Polar TM3 R 159 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM6 H 288 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 H 288 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic C-term S 390 - G.H3 W 263 G.H3.17
Hydrophobic TM5 L 258 5x65 G.H5 L 353 G.H5.20
Hydrophobic C-term L 398 - G.H3 L 254 G.H3.08
Van-der-waals C-term L 398 - G.H3 L 254 G.H3.08
Hydrophobic TM3 V 163 3x54 G.H5 L 353 G.H5.20
Polar ICL3 Y 281 - G.S6 S 326 G.S6.03
Hydrophobic TM6 V 295 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 295 6x33 G.H5 L 358 G.H5.25
Ionic TM5 E 261 5x68 G.H5 K 345 G.H5.12
Polar TM5 E 261 5x68 G.H5 K 345 G.H5.12
Hydrophobic TM3 A 162 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 162 3x53 G.H5 Y 356 G.H5.23
Polar C-term T 394 - G.H3 Y 261 G.H3.15
Hydrophobic C-term T 394 - G.H3 Y 261 G.H3.15
Van-der-waals C-term T 394 - G.H3 Y 261 G.H3.15
Polar TM2 T 95 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 95 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 95 2x39 G.H5 Y 356 G.H5.23
Polar TM3 A 162 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 162 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 162 3x53 G.H5 N 352 G.H5.19
Ionic ICL3 R 280 - G.H4 D 315 G.H4.17
Polar ICL3 R 280 - G.H4 D 315 G.H4.17
Van-der-waals ICL3 R 280 - G.H4 D 315 G.H4.17
Polar ICL2 R 170 34x54 G.h2s4 T 224 G.h2s4.05
Van-der-waals ICL2 R 170 34x54 G.h2s4 T 224 G.h2s4.05
Polar C-term C 399 - G.H2 R 214 G.H2.05
Hydrophobic C-term C 399 - G.H2 R 214 G.H2.05
Van-der-waals C-term C 399 - G.H2 R 214 G.H2.05
Hydrophobic ICL3 A 275 - G.H4 E 307 G.H4.09
Van-der-waals ICL3 A 275 - G.H4 E 307 G.H4.09
Polar ICL3 Y 281 - G.S6 I 324 G.S6.01
Van-der-waals ICL3 Y 281 - G.S6 I 324 G.S6.01
Hydrophobic C-term V 401 - G.H3 A 253 G.H3.07
Van-der-waals C-term V 401 - G.H3 A 253 G.H3.07
Hydrophobic ICL2 S 171 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic H8 F 363 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 363 8x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 R 170 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 170 34x54 G.S1 L 40 G.S1.02
Hydrophobic ICL2 L 167 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 167 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM6 M 298 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 298 6x36 G.H5 L 358 G.H5.25
Polar ICL3 R 284 - G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL3 R 284 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 R 284 - G.h4s6 S 320 G.h4s6.11
Ionic TM6 R 292 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 292 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 292 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM2 L 99 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 L 99 2x43 G.H5 N 357 G.H5.24
Polar ICL3 R 272 - G.S6 H 327 G.S6.04
Van-der-waals ICL3 R 272 - G.S6 H 327 G.S6.04
Polar H8 S 360 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 360 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 360 8x47 G.H5 N 357 G.H5.24
Hydrophobic C-term L 398 - G.h2s4 F 220 G.h2s4.01
Hydrophobic ICL2 P 166 34x50 G.H5 K 345 G.H5.12
Polar ICL3 R 284 - G.h4s6 D 319 G.h4s6.10
Van-der-waals ICL3 R 284 - G.h4s6 D 319 G.h4s6.10
Hydrophobic ICL2 P 166 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL3 R 272 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 R 272 - G.H5 F 339 G.H5.06
Polar ICL3 R 284 - G.h4s6 K 322 G.h4s6.13
Hydrophobic TM5 L 258 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM5 E 261 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 E 261 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 R 257 5x64 G.H5 K 345 G.H5.12
Polar TM3 R 159 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 V 163 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 163 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL3 Y 281 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 Y 281 - G.S6 Y 325 G.S6.02
Hydrophobic ICL2 L 167 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL2 L 167 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 167 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 S 171 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 M 298 6x36 G.H5 N 357 G.H5.24
Polar TM7 Y 356 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 356 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 167 34x51 G.S3 V 199 G.S3.01
Polar ICL2 P 166 34x50 G.H5 N 352 G.H5.19
Polar C-term T 397 - G.H3 Y 261 G.H3.15
Van-der-waals C-term T 397 - G.H3 Y 261 G.H3.15
Van-der-waals ICL2 V 173 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 166 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM6 L 299 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 295 6x33 G.H5 L 353 G.H5.20
Hydrophobic C-term L 398 - G.H2 R 213 G.H2.04
Polar ICL3 R 272 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 R 272 - G.S6 S 326 G.S6.03
Polar ICL2 R 170 34x54 G.S1 E 39 G.S1.01
Hydrophobic TM3 R 159 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 159 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 295 6x33 G.H5 V 359 G.H5.26
Polar C-term C 399 - G.H2 R 210 G.H2.01
Hydrophobic C-term C 399 - G.H2 R 210 G.H2.01
Van-der-waals C-term C 399 - G.H2 R 210 G.H2.01
Hydrophobic TM4 T 174 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 174 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic C-term L 398 - G.H3 I 258 G.H3.12
Hydrophobic C-term L 398 - G.H2 W 216 G.H2.07
Polar H8 S 361 8x48 G.H5 V 359 G.H5.26
Polar TM6 H 288 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 H 288 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 H 288 6x26 G.H5 Q 350 G.H5.17
Hydrophobic ICL3 R 280 - G.H4 K 311 G.H4.13