Gs - NMU2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 80 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 80 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 258 6x25 G.S6 P 361 G.S6.03
Van-der-waals TM6 I 258 6x25 G.S6 P 361 G.S6.03
Hydrophobic ICL2 P 151 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 151 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 151 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 151 34x50 G.H5 H 387 G.H5.19
Hydrophobic H8 F 334 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 334 8x50 G.H5 E 392 G.H5.24
Polar TM6 N 255 6x22 G.S6 P 361 G.S6.03
Hydrophobic TM6 N 255 6x22 G.S6 P 361 G.S6.03
Van-der-waals TM6 N 255 6x22 G.S6 P 361 G.S6.03
Hydrophobic TM6 R 260 6x27 G.h4s6 Y 358 G.h4s6.20
Polar TM3 R 144 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 Y 391 G.H5.23
Polar TM5 D 246 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 D 246 5x68 G.H5 Q 384 G.H5.16
Polar H8 S 331 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 331 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 E 392 G.H5.24
Polar TM6 N 257 6x24 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 N 257 6x24 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 N 257 6x24 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 242 5x64 G.H5 R 380 G.H5.12
Van-der-waals TM5 R 242 5x64 G.H5 R 380 G.H5.12
Polar ICL3 G 254 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 G 254 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 G 254 - G.hgh4 T 325 G.hgh4.15
Polar ICL2 K 155 34x54 G.h2s4 T 242 G.h2s4.05
Ionic TM5 E 250 5x72 G.H5 R 385 G.H5.17
Polar TM5 E 250 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 250 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 250 5x72 G.H5 D 381 G.H5.13
Hydrophobic TM6 I 258 6x25 G.H4 L 346 G.H4.16
Polar ICL2 K 155 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 155 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 K 155 34x54 G.S1 H 41 G.S1.02
Polar TM4 R 161 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM4 R 161 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 R 161 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM5 L 243 5x65 G.H5 L 388 G.H5.20
Aromatic ICL2 F 152 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 152 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 152 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 151 34x50 G.H5 Q 384 G.H5.16
Ionic TM6 R 260 6x27 G.H5 D 381 G.H5.13
Polar TM6 R 260 6x27 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 148 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 144 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 155 34x54 G.H5 I 383 G.H5.15
Hydrophobic TM6 C 262 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 C 262 6x29 G.H5 L 394 G.H5.26
Ionic TM5 D 246 5x68 G.H5 R 380 G.H5.12
Polar TM5 D 246 5x68 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 152 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 152 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 152 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 152 34x51 G.H5 I 383 G.H5.15
Polar ICL2 K 155 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 155 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 151 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 151 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 152 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 A 147 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 M 269 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 152 34x51 G.S3 F 219 G.S3.03
Polar ICL3 D 252 - G.hgh4 T 325 G.hgh4.15
Hydrophobic C-term L 374 - G.H2 R 231 G.H2.04
Hydrophobic TM6 L 270 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 243 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM2 L 84 2x43 G.H5 E 392 G.H5.24
Van-der-waals TM2 L 84 2x43 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 260 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 260 6x27 G.H5 R 385 G.H5.17
Hydrophobic TM7 Y 327 7x53 G.H5 E 392 G.H5.24
Van-der-waals TM7 Y 327 7x53 G.H5 E 392 G.H5.24
Aromatic TM6 R 260 6x27 G.S6 Y 360 G.S6.02
Hydrophobic TM6 R 260 6x27 G.S6 Y 360 G.S6.02
Van-der-waals TM6 R 260 6x27 G.S6 Y 360 G.S6.02
Polar TM3 E 143 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 143 3x49 G.H5 Y 391 G.H5.23
Polar TM3 I 148 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 148 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 Q 384 G.H5.16
Polar TM6 R 263 6x30 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 266 6x33 G.H5 L 394 G.H5.26
Ionic TM6 R 263 6x30 G.H5 D 381 G.H5.13
Polar TM6 R 263 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 263 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 263 6x30 G.H5 D 381 G.H5.13
Hydrophobic ICL2 F 152 34x51 G.H5 C 379 G.H5.11
Ionic C-term E 376 - G.H2 R 228 G.H2.01
Polar C-term E 376 - G.H2 R 228 G.H2.01
Hydrophobic TM6 V 266 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 266 6x33 G.H5 L 393 G.H5.25
Polar TM2 T 80 2x39 G.H5 Q 390 G.H5.22
Polar TM6 R 260 6x27 G.S6 C 359 G.S6.01
Van-der-waals TM6 R 260 6x27 G.S6 C 359 G.S6.01
Hydrophobic C-term V 372 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 A 154 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 154 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 256 6x23 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 L 273 6x40 G.H5 L 393 G.H5.25
Polar TM2 T 78 2x37 G.H5 Q 390 G.H5.22
Polar TM3 A 147 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 H 387 G.H5.19
Polar TM7 N 328 7x54 G.H5 E 392 G.H5.24
Hydrophobic TM7 N 328 7x54 G.H5 E 392 G.H5.24
Van-der-waals TM7 N 328 7x54 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 156 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 L 156 34x55 G.hns1 A 39 G.hns1.03
Polar ICL3 G 254 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 G 254 - G.H4 R 342 G.H4.12
Hydrophobic TM6 V 266 6x33 G.H5 L 388 G.H5.20
Aromatic ICL2 F 152 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 152 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 152 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM3 I 148 3x54 G.H5 L 393 G.H5.25