G12 - NPBW2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 149 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 T 149 - G.H5 L 371 G.H5.16
Polar H8 N 322 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 149 - G.H5 L 375 G.H5.20
Hydrophobic TM6 V 258 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 V 258 6x33 G.H5 I 378 G.H5.23
Polar ICL2 S 152 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 S 152 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 S 152 - G.H5 K 367 G.H5.12
Ionic ICL2 H 154 - G.H5 E 373 G.H5.18
Polar ICL2 H 154 - G.H5 E 373 G.H5.18
Hydrophobic ICL2 H 154 - G.H5 E 373 G.H5.18
Van-der-waals ICL2 H 154 - G.H5 E 373 G.H5.18
Hydrophobic H8 D 320 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 320 8x47 G.H5 L 380 G.H5.25
Ionic ICL2 R 158 - G.H5 D 377 G.H5.22
Polar ICL2 R 158 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 158 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 158 - G.H5 D 377 G.H5.22
Hydrophobic TM3 V 146 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 146 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM2 I 84 2x43 G.H5 L 380 G.H5.25
Polar ICL3 R 245 - G.H5 H 364 G.H5.09
Aromatic ICL3 R 245 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 R 245 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 R 245 - G.H5 H 364 G.H5.09
Hydrophobic TM6 A 254 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 254 6x29 G.H5 M 379 G.H5.24
Polar ICL3 R 245 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 245 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 245 - G.H5 D 368 G.H5.13
Hydrophobic TM3 V 145 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 145 3x53 G.H5 I 378 G.H5.23
Polar ICL3 S 246 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 244 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 L 244 - G.H5 D 368 G.H5.13
Hydrophobic TM6 K 253 6x28 G.H5 M 379 G.H5.24
Polar ICL3 S 246 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 S 246 - G.H5 D 368 G.H5.13
Polar TM3 A 148 3x56 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 148 3x56 G.H5 N 374 G.H5.19
Hydrophobic ICL2 S 152 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 S 152 - G.H5 I 370 G.H5.15
Hydrophobic TM5 L 239 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 239 5x65 G.H5 L 375 G.H5.20
Polar TM6 K 257 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 257 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 244 - G.H5 L 375 G.H5.20
Hydrophobic TM6 L 261 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 153 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 153 - G.H5 I 370 G.H5.15
Hydrophobic TM2 T 80 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 T 80 2x39 G.H5 L 380 G.H5.25
Polar ICL2 R 153 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 153 - G.H5 N 374 G.H5.19
Hydrophobic TM6 A 254 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 254 6x29 G.H5 L 375 G.H5.20
Polar ICL2 P 156 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 156 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 156 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 145 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 145 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 V 242 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 H 154 - G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 H 154 - G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL3 L 244 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 L 244 - G.H5 L 371 G.H5.16
Van-der-waals H8 N 322 8x49 G.H5 Q 381 G.H5.26
Aromatic ICL2 W 157 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 W 157 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 W 157 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 153 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 153 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 V 145 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM6 L 251 6x26 G.H5 L 375 G.H5.20
Hydrophobic ICL2 H 154 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 154 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 W 157 - G.HN R 52 G.HN.52
Hydrophobic ICL3 L 244 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 S 246 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 S 246 - G.S6 F 347 G.S6.02
Polar ICL2 T 149 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 T 149 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 149 - G.H5 N 374 G.H5.19