G15 -
NPFF1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | P | 148 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 148 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 148 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | V | 372 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Hydrophobic | C-term | V | 372 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Van-der-waals | C-term | V | 372 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Polar | C-term | V | 372 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | R | 370 | - | G.H2 | E | 215 | G.H2.03 |
Hydrophobic | ICL2 | P | 148 | - | G.H5 | V | 363 | G.H5.15 |
Polar | C-term | F | 373 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Hydrophobic | C-term | F | 373 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Van-der-waals | C-term | F | 373 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Hydrophobic | C-term | V | 374 | - | G.S3 | D | 208 | G.S3.07 |
Van-der-waals | C-term | V | 374 | - | G.S3 | D | 208 | G.S3.07 |
Hydrophobic | C-term | V | 372 | - | G.S3 | V | 209 | G.S3.08 |
Van-der-waals | C-term | V | 372 | - | G.S3 | V | 209 | G.S3.08 |
Hydrophobic | ICL2 | F | 149 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 149 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | W | 428 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | W | 428 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM6 | R | 264 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 264 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | R | 370 | - | G.s4h3 | L | 242 | G.s4h3.08 |
Polar | C-term | S | 379 | - | G.h1ha | G | 69 | G.h1ha.03 |
Van-der-waals | C-term | S | 379 | - | G.h1ha | G | 69 | G.h1ha.03 |
Hydrophobic | C-term | Y | 360 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | Y | 360 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | N | 335 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 335 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | L | 368 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | L | 368 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | L | 368 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | L | 368 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | R | 377 | - | H.HA | G | 77 | H.HA.06 |
Hydrophobic | C-term | R | 377 | - | H.HA | G | 77 | H.HA.06 |
Van-der-waals | C-term | R | 377 | - | H.HA | G | 77 | H.HA.06 |
Hydrophobic | C-term | R | 371 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Van-der-waals | C-term | R | 371 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Hydrophobic | C-term | L | 367 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | L | 367 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM3 | C | 144 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | C | 144 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | V | 374 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Van-der-waals | C-term | V | 374 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Ionic | C-term | R | 371 | - | G.H2 | E | 215 | G.H2.03 |
Polar | C-term | R | 371 | - | G.H2 | E | 215 | G.H2.03 |
Hydrophobic | C-term | R | 371 | - | G.H2 | E | 215 | G.H2.03 |
Van-der-waals | C-term | R | 371 | - | G.H2 | E | 215 | G.H2.03 |
Hydrophobic | C-term | R | 371 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Van-der-waals | C-term | R | 371 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Hydrophobic | C-term | F | 373 | - | G.H2 | K | 218 | G.H2.06 |
Van-der-waals | C-term | F | 373 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | TM6 | V | 268 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | P | 378 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | F | 373 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | F | 373 | - | G.S2 | N | 193 | G.S2.02 |
Polar | C-term | V | 374 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | V | 374 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | V | 374 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | C-term | R | 377 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | R | 377 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | R | 377 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM6 | V | 268 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 268 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | V | 376 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | V | 376 | - | G.S2 | Y | 195 | G.S2.04 |
Ionic | C-term | E | 362 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Polar | C-term | E | 362 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Ionic | ICL3 | E | 254 | - | G.H4 | R | 310 | G.H4.09 |
Polar | ICL3 | E | 254 | - | G.H4 | R | 310 | G.H4.09 |
Van-der-waals | ICL3 | E | 254 | - | G.H4 | R | 310 | G.H4.09 |
Hydrophobic | C-term | R | 371 | - | G.H2 | W | 219 | G.H2.07 |
Polar | C-term | R | 377 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | R | 377 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | R | 377 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | TM6 | M | 271 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | M | 271 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | R | 370 | - | G.s3h2 | Q | 212 | G.s3h2.03 |
Van-der-waals | C-term | R | 370 | - | G.s3h2 | Q | 212 | G.s3h2.03 |
Hydrophobic | TM3 | C | 144 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | C | 144 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM4 | R | 156 | 4x40 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM4 | R | 156 | 4x40 | G.HN | M | 1 | G.HN.01 |
Ionic | C-term | R | 370 | - | G.H3 | E | 253 | G.H3.04 |
Polar | C-term | R | 370 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | C-term | R | 370 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | C-term | R | 370 | - | G.H3 | E | 253 | G.H3.04 |
Polar | C-term | F | 373 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Hydrophobic | C-term | F | 373 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Van-der-waals | C-term | F | 373 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Polar | C-term | S | 379 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | S | 379 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | S | 379 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | ICL2 | F | 149 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | V | 372 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Van-der-waals | C-term | V | 372 | - | G.s3h2 | Q | 212 | G.s3h2.03 |
Polar | C-term | L | 368 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | L | 368 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 368 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | V | 376 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | V | 376 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | R | 370 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Hydrophobic | C-term | R | 370 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Van-der-waals | C-term | R | 370 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Hydrophobic | TM2 | T | 78 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | R | 371 | - | G.H2 | K | 218 | G.H2.06 |
Van-der-waals | C-term | R | 371 | - | G.H2 | K | 218 | G.H2.06 |
Polar | C-term | W | 428 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | C-term | R | 370 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | R | 370 | - | G.H2 | K | 213 | G.H2.01 |
Polar | ICL3 | E | 255 | - | G.S6 | S | 341 | G.S6.03 |
Hydrophobic | ICL3 | E | 255 | - | G.S6 | S | 341 | G.S6.03 |
Van-der-waals | ICL3 | E | 255 | - | G.S6 | S | 341 | G.S6.03 |
Hydrophobic | C-term | R | 371 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Van-der-waals | C-term | R | 371 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Polar | C-term | H | 369 | - | G.H2 | E | 215 | G.H2.03 |
Hydrophobic | C-term | H | 369 | - | G.H2 | E | 215 | G.H2.03 |
Van-der-waals | C-term | H | 369 | - | G.H2 | E | 215 | G.H2.03 |
Hydrophobic | C-term | F | 373 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | F | 373 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | L | 367 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 367 | - | G.H2 | R | 216 | G.H2.04 |
Polar | C-term | R | 413 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | C-term | R | 413 | - | H.hbhc | K | 123 | H.hbhc.02 |
Van-der-waals | C-term | R | 413 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | L | 367 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | L | 367 | - | G.H3 | L | 264 | G.H3.15 |
Polar | C-term | H | 369 | - | G.H2 | S | 214 | G.H2.02 |
Polar | C-term | V | 375 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 149 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | F | 373 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Van-der-waals | C-term | F | 373 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Hydrophobic | C-term | V | 374 | - | G.H1 | S | 56 | G.H1.02 |
Van-der-waals | C-term | V | 374 | - | G.H1 | S | 56 | G.H1.02 |
Polar | H8 | N | 335 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Polar | C-term | R | 371 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Van-der-waals | C-term | R | 371 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Hydrophobic | C-term | P | 364 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | P | 364 | - | G.H3 | W | 266 | G.H3.17 |
Polar | TM2 | N | 79 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | N | 79 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | H | 369 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | H | 369 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | H | 369 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | R | 371 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | R | 371 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | V | 372 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Van-der-waals | C-term | V | 372 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Hydrophobic | TM5 | L | 243 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | R | 370 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | R | 370 | - | G.H2 | W | 219 | G.H2.07 |
Van-der-waals | C-term | R | 370 | - | G.H2 | W | 219 | G.H2.07 |
Polar | C-term | E | 414 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | C-term | E | 414 | - | H.hbhc | K | 123 | H.hbhc.02 |
Van-der-waals | C-term | E | 414 | - | H.hbhc | K | 123 | H.hbhc.02 |
Polar | C-term | H | 369 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | H | 369 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | H | 369 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | S | 381 | - | G.h1ha | A | 68 | G.h1ha.02 |
Ionic | ICL2 | K | 152 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | K | 152 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | K | 152 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | K | 152 | - | G.H5 | E | 370 | G.H5.22 |
Aromatic | ICL2 | F | 149 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 149 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM6 | R | 264 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 264 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | V | 372 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Van-der-waals | C-term | V | 372 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Hydrophobic | C-term | V | 372 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Van-der-waals | C-term | V | 372 | - | G.s3h2 | G | 211 | G.s3h2.02 |
Ionic | H8 | E | 334 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | H8 | E | 334 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | H8 | E | 334 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | E | 334 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Aromatic | C-term | R | 377 | - | H.HA | F | 78 | H.HA.07 |
Polar | C-term | R | 371 | - | G.H2 | S | 214 | G.H2.02 |
Ionic | C-term | R | 370 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Polar | C-term | R | 370 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Hydrophobic | C-term | R | 370 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Van-der-waals | C-term | R | 370 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Polar | C-term | V | 372 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | V | 372 | - | G.S2 | N | 193 | G.S2.02 |
Polar | H8 | N | 333 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | N | 333 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 333 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | P | 148 | - | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | H | 369 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | H | 369 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | H | 369 | - | G.H2 | K | 213 | G.H2.01 |
Polar | C-term | V | 374 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | V | 374 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | V | 374 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | P | 412 | - | H.hbhc | K | 123 | H.hbhc.02 |
Van-der-waals | C-term | P | 412 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | C-term | R | 370 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | R | 370 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM5 | L | 243 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | S | 379 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | S | 379 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | R | 370 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Hydrophobic | C-term | R | 370 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Van-der-waals | C-term | R | 370 | - | G.s3h2 | G | 210 | G.s3h2.01 |
Hydrophobic | ICL2 | K | 152 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | K | 152 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | P | 364 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | S | 379 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | S | 379 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | S | 379 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | L | 399 | - | G.HN | I | 31 | G.HN.46 |