G12 - NPFF2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 374 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 374 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM2 I 186 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 255 - G.hns1 R 56 G.hns1.03
Hydrophobic H8 F 442 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 249 3x54 G.H5 L 371 G.H5.16
Aromatic ICL2 F 253 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 363 G.H5.08
Hydrophobic TM5 L 348 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 249 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 249 3x54 G.H5 L 375 G.H5.20
Polar TM3 C 248 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 248 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 248 3x53 G.H5 N 374 G.H5.19
Ionic ICL2 K 256 - G.H5 D 377 G.H5.22
Polar ICL2 K 256 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 K 256 - G.H5 D 377 G.H5.22
Polar ICL3 Q 363 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 Q 363 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 Q 363 - G.h4s6 K 344 G.h4s6.19
Polar ICL3 Q 363 - G.S6 L 346 G.S6.01
Ionic ICL2 K 256 - G.H5 E 373 G.H5.18
Hydrophobic TM6 I 374 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 I 374 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 348 5x65 G.H5 L 371 G.H5.16
Polar ICL2 K 256 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 K 256 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 256 - G.H5 N 374 G.H5.19
Hydrophobic TM3 V 249 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 249 3x54 G.H5 I 378 G.H5.23
Polar H8 N 441 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 441 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 441 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM3 C 248 3x53 G.H5 I 378 G.H5.23
Polar ICL3 Q 363 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 Q 363 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM2 N 183 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 183 2x40 G.H5 L 380 G.H5.25
Polar ICL3 K 359 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 K 359 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 K 359 - G.H4 Q 333 G.H4.13
Hydrophobic H8 N 439 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 439 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 255 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 F 253 - G.S1 V 58 G.S1.02
Hydrophobic TM5 A 351 5x68 G.H5 L 371 G.H5.16
Polar H8 E 440 8x48 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 245 3x50 G.H5 I 378 G.H5.23
Polar H8 N 441 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 441 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 441 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 253 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 K 367 G.H5.12
Hydrophobic TM6 K 371 6x30 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 253 - G.H5 V 366 G.H5.11
Van-der-waals TM4 T 258 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 H 355 5x72 G.H5 F 361 G.H5.06
Hydrophobic TM6 V 367 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 252 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 252 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 Q 363 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 363 - G.h4s6 P 345 G.h4s6.20
Polar ICL2 P 252 - G.H5 N 374 G.H5.19
Hydrophobic TM6 K 370 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 373 6x32 G.H5 M 379 G.H5.24
Polar H8 E 440 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 252 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 253 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 370 G.H5.15
Hydrophobic TM2 T 180 2x37 G.H5 L 380 G.H5.25
Polar TM6 K 370 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 370 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 370 6x29 G.H5 Q 381 G.H5.26
Polar ICL3 N 360 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 N 360 - G.S6 H 348 G.S6.03
Hydrophobic TM6 K 371 6x30 G.H5 L 375 G.H5.20
Ionic TM6 K 371 6x30 G.H5 D 368 G.H5.13
Polar TM6 K 371 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 K 371 6x30 G.H5 D 368 G.H5.13
Polar H8 N 439 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 N 439 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 439 8x47 G.H5 M 379 G.H5.24
Polar ICL3 Q 363 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 Q 363 - G.h4s6 R 339 G.h4s6.08
Hydrophobic ICL2 F 253 - G.S3 F 223 G.S3.03
Polar ICL3 N 360 - G.S6 L 346 G.S6.01
Hydrophobic ICL2 F 253 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 I 221 G.S3.01
Polar H8 E 440 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 440 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 440 8x48 G.H5 Q 381 G.H5.26