Gs - NPFF2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 R 358 - G.hgh4 E 322 G.hgh4.12
Polar ICL3 R 358 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 R 358 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM6 L 378 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 I 374 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 252 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 252 - G.H5 H 387 G.H5.19
Polar ICL3 R 358 - G.hgh4 T 320 G.hgh4.10
Hydrophobic ICL3 R 358 - G.hgh4 T 320 G.hgh4.10
Van-der-waals ICL3 R 358 - G.hgh4 T 320 G.hgh4.10
Polar ICL2 K 256 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 256 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 256 - G.H5 H 387 G.H5.19
Polar TM5 A 352 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 A 352 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 P 354 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 P 354 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM6 I 374 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL3 R 358 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 358 - G.hgh4 P 321 G.hgh4.11
Polar ICL3 Q 363 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 Q 363 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 Q 363 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 P 252 - G.H5 Q 384 G.H5.16
Hydrophobic TM6 I 374 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 374 6x33 G.H5 L 393 G.H5.25
Polar ICL3 R 358 - G.hgh4 T 319 G.hgh4.09
Van-der-waals ICL3 R 358 - G.hgh4 T 319 G.hgh4.09
Hydrophobic ICL2 F 253 - G.H5 C 379 G.H5.11
Hydrophobic TM3 R 245 3x50 G.H5 L 393 G.H5.25
Polar H8 E 440 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 E 440 8x48 G.H5 E 392 G.H5.24
Polar H8 F 442 8x50 G.H5 E 392 G.H5.24
Aromatic ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 R 380 G.H5.12
Polar H8 N 441 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 N 441 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 N 441 8x49 G.H5 E 392 G.H5.24
Polar TM5 S 347 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 S 347 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 249 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 249 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL3 N 360 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 N 360 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 L 348 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 348 5x65 G.H5 L 388 G.H5.20
Polar TM3 V 249 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 249 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 249 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 252 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 252 - G.H5 R 380 G.H5.12
Hydrophobic TM5 P 354 5x71 G.S6 Y 360 G.S6.02
Hydrophobic ICL2 F 253 - G.S3 F 219 G.S3.03
Polar ICL3 Q 363 - G.h4s6 G 353 G.h4s6.09
Ionic TM5 H 355 5x72 G.hgh4 D 323 G.hgh4.13
Polar TM5 H 355 5x72 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 H 355 5x72 G.hgh4 D 323 G.hgh4.13
Polar TM6 K 370 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 370 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 370 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 252 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 252 - G.H5 I 383 G.H5.15
Aromatic ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic TM6 V 367 6x26 G.h4s6 Y 358 G.h4s6.20
Polar ICL2 K 256 - G.H5 Q 390 G.H5.22
Van-der-waals ICL2 K 256 - G.H5 Q 390 G.H5.22
Polar TM3 R 245 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 245 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 245 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 G 357 - G.H4 L 346 G.H4.16
Van-der-waals TM5 H 355 5x72 G.H4 L 346 G.H4.16
Hydrophobic ICL2 F 253 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 V 217 G.S3.01
Polar TM2 T 182 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 182 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 182 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 253 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 383 G.H5.15
Polar TM3 D 244 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 244 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 244 3x49 G.H5 Y 391 G.H5.23
Polar H8 N 439 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 439 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 439 8x47 G.H5 E 392 G.H5.24
Polar TM3 C 248 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 C 248 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 C 248 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 M 377 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 377 6x36 G.H5 L 393 G.H5.25
Polar TM3 C 248 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 C 248 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 C 248 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 249 3x54 G.H5 L 393 G.H5.25