G12 - Y1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 I 79 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL3 R 249 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 R 249 - G.h4s6 P 345 G.h4s6.20
Polar ICL2 P 145 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 145 - G.H5 N 374 G.H5.19
Van-der-waals TM5 R 237 5x64 G.H5 K 367 G.H5.12
Ionic TM5 R 241 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 241 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 368 G.H5.13
Polar TM6 R 254 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 254 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 254 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 M 264 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 264 6x36 G.H5 M 379 G.H5.24
Van-der-waals ICL2 W 148 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 146 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 146 - G.H5 I 370 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 261 6x33 G.H5 L 375 G.H5.20
Polar TM6 N 251 6x23 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 N 251 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 M 245 5x72 G.H5 A 365 G.H5.10
Polar TM6 N 251 6x23 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 N 251 6x23 G.h4s6 R 342 G.h4s6.11
Polar ICL2 G 147 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 147 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 147 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 L 141 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 I 378 G.H5.23
Polar TM3 R 138 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 I 378 G.H5.23
Polar TM5 R 241 5x68 G.H5 H 364 G.H5.09
Hydrophobic ICL3 R 249 - G.S6 F 347 G.S6.02
Ionic TM6 R 254 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 254 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 254 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 254 6x26 G.H5 D 368 G.H5.13
Polar TM6 N 251 6x23 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 P 145 - G.H5 K 367 G.H5.12
Hydrophobic TM6 R 254 6x26 G.S6 F 347 G.S6.02
Van-der-waals TM6 R 254 6x26 G.S6 F 347 G.S6.02
Hydrophobic TM3 I 142 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 L 371 G.H5.16
Polar H8 N 326 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 326 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 326 8x49 G.H5 L 380 G.H5.25
Polar TM3 L 141 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 L 238 5x65 G.H5 L 371 G.H5.16
Polar H8 K 325 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 325 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM5 M 244 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 M 244 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 M 245 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 M 245 5x72 G.S6 F 347 G.S6.02
Polar ICL3 R 249 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 R 249 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM2 N 76 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 76 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 I 261 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 261 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 145 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 145 - G.H5 I 370 G.H5.15
Hydrophobic TM6 R 254 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 254 6x26 G.h4s6 P 345 G.h4s6.20
Polar H8 N 326 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 326 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 326 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 142 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL1 M 71 12x50 G.H5 L 380 G.H5.25
Aromatic ICL2 R 146 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 R 146 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 R 146 - G.H5 F 363 G.H5.08
Hydrophobic TM5 L 238 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 238 5x65 G.H5 L 375 G.H5.20
Polar TM5 R 241 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 241 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 241 5x68 G.H5 K 367 G.H5.12
Polar C-term T 354 - G.H2 Q 236 G.H2.05
Hydrophobic C-term T 354 - G.H2 Q 236 G.H2.05
Van-der-waals C-term T 354 - G.H2 Q 236 G.H2.05
Van-der-waals ICL2 R 146 - G.S3 F 223 G.S3.03
Hydrophobic ICL2 R 146 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 146 - G.S3 I 221 G.S3.01
Hydrophobic ICL3 M 248 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 M 248 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 M 248 - G.H5 F 361 G.H5.06
Hydrophobic H8 N 324 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 324 8x47 G.H5 L 380 G.H5.25
Polar ICL3 R 249 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 R 249 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 R 249 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 R 146 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 R 146 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 145 - G.H5 L 371 G.H5.16
Hydrophobic H8 K 325 8x48 G.H5 Q 381 G.H5.26
Polar ICL2 R 149 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 149 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 149 - G.H5 N 374 G.H5.19
Hydrophobic ICL3 M 248 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 M 248 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 R 146 - G.S1 V 58 G.S1.02
Hydrophobic TM5 M 245 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 M 245 5x72 G.H5 D 368 G.H5.13
Hydrophobic C-term I 350 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 350 - G.H3 K 284 G.H3.16
Ionic C-term E 348 - G.H3 K 284 G.H3.16
Polar C-term E 348 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 348 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 348 - G.H3 K 284 G.H3.16
Hydrophobic C-term M 352 - G.H2 F 239 G.H2.08
Van-der-waals C-term M 352 - G.H2 F 239 G.H2.08
Hydrophobic TM5 R 241 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 L 371 G.H5.16
Polar ICL3 M 248 - G.S6 H 348 G.S6.03