G12 - y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 N 249 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 N 249 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 N 249 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 138 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM2 T 71 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 R 142 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 142 - G.S3 I 221 G.S3.01
Hydrophobic TM4 S 147 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 147 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 R 252 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 252 6x26 G.h4s6 P 345 G.h4s6.20
Polar ICL2 K 145 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 K 145 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 145 - G.H5 N 374 G.H5.19
Polar TM2 N 69 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 N 69 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 69 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 138 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 258 6x32 G.H5 Q 381 G.H5.26
Polar ICL2 P 146 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 R 134 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM6 N 256 6x30 G.H5 L 375 G.H5.20
Ionic TM6 R 252 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 252 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 252 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 252 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM3 L 137 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 141 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 141 - G.H5 K 367 G.H5.12
Hydrophobic TM3 I 138 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 I 259 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 I 259 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 E 255 6x29 G.H5 Q 372 G.H5.17
Ionic TM5 R 239 5x68 G.H5 D 368 G.H5.13
Polar ICL3 K 246 - G.S6 H 348 G.S6.03
Aromatic ICL3 K 246 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 K 246 - G.S6 H 348 G.S6.03
Polar TM3 L 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 137 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 R 258 6x32 G.H5 M 379 G.H5.24
Polar TM4 H 150 4x41 G.HN R 52 G.HN.52
Hydrophobic TM4 H 150 4x41 G.HN R 52 G.HN.52
Hydrophobic ICL2 R 142 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 R 142 - G.H5 F 363 G.H5.08
Hydrophobic TM5 R 239 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 239 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 K 246 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 K 246 - G.H5 F 361 G.H5.06
Polar TM5 R 239 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 239 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 239 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 142 - G.H5 K 367 G.H5.12
Ionic ICL2 K 145 - G.H5 E 373 G.H5.18
Polar ICL2 K 145 - G.H5 E 373 G.H5.18
Hydrophobic ICL2 K 145 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 R 142 - G.H5 I 370 G.H5.15
Hydrophobic TM6 R 252 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 252 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 141 - G.H5 L 371 G.H5.16
Hydrophobic TM6 R 252 6x26 G.S6 F 347 G.S6.02
Van-der-waals TM6 R 252 6x26 G.S6 F 347 G.S6.02
Hydrophobic TM6 I 259 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 259 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM2 I 75 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 75 2x43 G.H5 L 380 G.H5.25
Polar TM1 K 63 1x60 G.H5 Q 381 G.H5.26
Hydrophobic TM1 K 63 1x60 G.H5 Q 381 G.H5.26
Van-der-waals TM1 K 63 1x60 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 236 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM2 S 72 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 141 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 141 - G.H5 I 370 G.H5.15
Polar ICL2 K 145 - G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 236 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM6 E 255 6x29 G.H5 M 379 G.H5.24
Polar TM1 K 63 1x60 G.H5 L 380 G.H5.25
Van-der-waals TM1 K 63 1x60 G.H5 L 380 G.H5.25
Polar ICL2 P 141 - G.H5 N 374 G.H5.19
Hydrophobic TM5 V 243 5x72 G.H5 H 364 G.H5.09