G12 - NTS1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 H 102 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 H 102 2x40 G.H5 L 380 G.H5.25
Polar TM3 A 169 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 169 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 169 3x53 G.H5 N 374 G.H5.19
Polar ICL2 T 178 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 178 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 178 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 174 34x51 G.H5 I 370 G.H5.15
Polar ICL2 M 180 34x57 G.hns1 R 55 G.hns1.02
Polar ICL2 K 177 34x54 G.S1 L 57 G.S1.01
Hydrophobic ICL2 K 177 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 K 177 34x54 G.S1 L 57 G.S1.01
Hydrophobic TM3 I 170 3x54 G.H5 L 375 G.H5.20
Aromatic ICL3 F 286 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 F 286 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 F 286 - G.H5 F 361 G.H5.06
Hydrophobic TM7 V 367 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 V 367 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 97 2x35 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 G 301 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 301 6x33 G.H5 M 379 G.H5.24
Aromatic ICL2 F 174 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 174 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 174 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM3 A 169 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 169 3x53 G.H5 I 378 G.H5.23
Polar ICL3 S 287 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 287 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 287 - G.S6 H 348 G.S6.03
Polar H8 S 368 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 174 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 174 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 P 173 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 173 34x50 G.H5 K 367 G.H5.12
Polar TM6 R 294 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 294 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 294 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 F 174 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 174 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM2 V 101 2x39 G.H5 I 378 G.H5.23
Polar ICL3 T 278 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 T 278 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 M 288 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 M 288 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 K 177 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 F 286 - G.H5 A 365 G.H5.10
Hydrophobic TM5 M 266 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 173 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 173 34x50 G.H5 L 371 G.H5.16
Polar ICL3 E 291 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 E 291 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 E 291 - G.h4s6 S 343 G.h4s6.12
Polar TM2 S 96 2x34 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 S 96 2x34 G.hns1 R 55 G.hns1.02
Polar TM1 K 91 1x60 G.H5 Q 381 G.H5.26
Polar H8 F 371 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 F 371 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM7 Y 364 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 263 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 263 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 F 286 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 F 286 - G.S6 F 347 G.S6.02
Polar H8 S 368 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 368 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 368 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL3 M 288 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 174 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 F 174 34x51 G.H5 V 366 G.H5.11
Polar H8 N 370 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 370 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 370 8x49 G.H5 Q 381 G.H5.26
Polar ICL2 K 177 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 K 177 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM3 R 166 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 I 378 G.H5.23
Polar ICL3 G 281 - G.S6 H 349 G.S6.04
Hydrophobic ICL2 K 177 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 E 291 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 E 291 - G.h4s6 R 342 G.h4s6.11
Polar TM4 S 183 4x40 G.HN R 52 G.HN.52
Hydrophobic ICL2 F 174 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 K 177 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 177 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 170 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 170 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM2 L 105 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 105 2x43 G.H5 L 380 G.H5.25
Polar H8 S 368 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 368 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL3 F 286 - G.H5 H 364 G.H5.09
Hydrophobic TM6 R 294 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 294 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 M 266 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 M 266 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 M 288 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 M 288 - G.S6 F 347 G.S6.02
Hydrophobic TM6 L 298 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL3 A 289 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 A 289 - G.h4s6 P 345 G.h4s6.20
Polar TM2 Q 98 2x36 G.H5 D 377 G.H5.22
Hydrophobic TM2 Q 98 2x36 G.H5 D 377 G.H5.22
Van-der-waals TM2 Q 98 2x36 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 170 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 170 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 174 34x51 G.S3 F 223 G.S3.03
Polar TM2 L 97 2x35 G.H5 D 377 G.H5.22
Hydrophobic TM2 L 97 2x35 G.H5 D 377 G.H5.22
Van-der-waals TM2 L 97 2x35 G.H5 D 377 G.H5.22
Hydrophobic ICL3 I 290 - G.h4s6 P 345 G.h4s6.20