Gi2 - μ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 174 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 344 G.H5.15
Hydrophobic C-term P 400 - H.HA Q 68 H.HA.06
Van-der-waals C-term P 400 - H.HA Q 68 H.HA.06
Polar C-term Q 388 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term Q 388 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term Q 388 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL3 L 267 - G.H5 L 349 G.H5.20
Ionic TM5 R 260 5x64 G.H5 D 342 G.H5.13
Polar TM5 R 260 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 260 5x64 G.H5 D 342 G.H5.13
Polar ICL3 R 265 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 265 - G.H5 D 342 G.H5.13
Polar C-term T 385 - G.H2 R 206 G.H2.01
Van-der-waals C-term T 385 - G.H2 R 206 G.H2.01
Polar C-term T 385 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic C-term T 385 - G.s3h2 Q 205 G.s3h2.03
Van-der-waals C-term T 385 - G.s3h2 Q 205 G.s3h2.03
Polar C-term D 383 - G.H2 R 209 G.H2.04
Hydrophobic C-term D 383 - G.H2 R 209 G.H2.04
Van-der-waals C-term D 383 - G.H2 R 209 G.H2.04
Polar C-term Q 388 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term Q 388 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term Q 388 - G.hfs2 K 181 G.hfs2.04
Polar C-term N 386 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term N 386 - G.s4h3 E 237 G.s4h3.10
Polar C-term Q 370 - G.H3 K 258 G.H3.16
Van-der-waals C-term Q 370 - G.H3 K 258 G.H3.16
Polar TM2 T 105 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 167 3x50 G.H5 L 354 G.H5.25
Ionic ICL3 R 265 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 265 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 265 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 265 - G.h4s6 E 319 G.h4s6.12
Polar C-term N 386 - G.H2 R 209 G.H2.04
Van-der-waals C-term N 386 - G.H2 R 209 G.H2.04
Hydrophobic TM5 R 260 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 260 5x64 G.H5 I 345 G.H5.16
Polar C-term R 384 - G.H2 R 209 G.H2.04
Hydrophobic C-term R 384 - G.H2 R 209 G.H2.04
Van-der-waals C-term R 384 - G.H2 R 209 G.H2.04
Polar C-term N 386 - G.H3 E 246 G.H3.04
Hydrophobic C-term N 386 - G.H3 E 246 G.H3.04
Van-der-waals C-term N 386 - G.H3 E 246 G.H3.04
Polar C-term T 385 - G.H2 S 207 G.H2.02
Van-der-waals C-term T 385 - G.H2 S 207 G.H2.02
Hydrophobic C-term T 385 - G.H2 W 212 G.H2.07
Hydrophobic H8 E 343 8x48 G.H5 F 355 G.H5.26
Polar H8 N 344 8x49 G.H5 D 351 G.H5.22
Polar H8 E 343 8x48 G.H5 G 353 G.H5.24
Hydrophobic H8 E 343 8x48 G.H5 G 353 G.H5.24
Van-der-waals H8 E 343 8x48 G.H5 G 353 G.H5.24
Ionic C-term E 390 - G.H2 R 206 G.H2.01
Polar C-term E 390 - G.H2 R 206 G.H2.01
Hydrophobic C-term E 390 - G.H2 R 206 G.H2.01
Van-der-waals C-term E 390 - G.H2 R 206 G.H2.01
Ionic C-term D 374 - G.H2 K 210 G.H2.05
Polar C-term D 374 - G.H2 K 210 G.H2.05
Ionic C-term R 384 - G.H2 E 208 G.H2.03
Hydrophobic C-term R 384 - G.H2 E 208 G.H2.03
Hydrophobic ICL2 L 178 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 178 34x54 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 178 34x54 G.H5 I 344 G.H5.15
Ionic C-term E 393 - H.HA K 86 H.HA.24
Polar C-term E 393 - H.HA K 86 H.HA.24
Hydrophobic C-term E 393 - H.HA K 86 H.HA.24
Van-der-waals C-term E 393 - H.HA K 86 H.HA.24
Hydrophobic ICL3 M 266 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 K 346 G.H5.17
Polar C-term V 382 - G.H2 R 209 G.H2.04
Hydrophobic TM6 I 280 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 354 G.H5.25
Aromatic TM6 R 279 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 279 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 279 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL2 V 175 34x51 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 V 175 34x51 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL3 M 266 - G.S5 S 264 G.S5.01
Polar C-term D 383 - G.H2 K 210 G.H2.05
Van-der-waals C-term D 383 - G.H2 K 210 G.H2.05
Ionic ICL2 R 181 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 181 34x57 G.H5 D 351 G.H5.22
Hydrophobic ICL2 R 181 34x57 G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 181 34x57 G.H5 D 351 G.H5.22
Polar ICL3 M 266 - G.H5 D 342 G.H5.13
Hydrophobic C-term H 387 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term H 387 - G.s4h3 E 237 G.s4h3.10
Hydrophobic H8 E 343 8x48 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 170 3x53 G.H5 C 352 G.H5.23
Van-der-waals H8 N 344 8x49 G.H5 G 353 G.H5.24
Hydrophobic C-term L 399 - G.hfs2 V 180 G.hfs2.03
Hydrophobic TM5 L 261 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 A 177 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 A 177 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 I 280 6x33 G.H5 F 355 G.H5.26
Ionic TM6 K 273 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 273 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 K 273 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 273 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 V 264 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 V 175 34x51 G.H5 F 337 G.H5.08
Polar C-term D 383 - G.H3 S 253 G.H3.11
Hydrophobic C-term T 385 - G.H2 R 209 G.H2.04
Van-der-waals C-term T 385 - G.H2 R 209 G.H2.04
Hydrophobic TM3 V 171 3x54 G.H5 L 349 G.H5.20
Polar TM6 S 270 6x23 G.h4s6 D 316 G.h4s6.09
Hydrophobic C-term A 394 - H.HA Q 79 H.HA.17
Polar ICL3 R 265 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 R 265 - G.S6 I 320 G.S6.01
Hydrophobic ICL2 P 174 34x50 G.H5 T 341 G.H5.12
Polar H8 N 344 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 N 344 8x49 G.H5 K 350 G.H5.21
Polar H8 R 347 8x52 G.H5 F 355 G.H5.26
Van-der-waals H8 R 347 8x52 G.H5 F 355 G.H5.26
Hydrophobic TM5 M 257 5x61 G.H5 L 349 G.H5.20
Hydrophobic ICL2 V 175 34x51 G.S3 L 195 G.S3.01
Ionic TM4 R 184 4x40 G.HN E 28 G.HN.52
Ionic ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Polar C-term N 371 - G.H3 K 258 G.H3.16
Van-der-waals C-term N 371 - G.H3 K 258 G.H3.16
Polar ICL2 R 181 34x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 R 181 34x57 G.H5 C 352 G.H5.23
Van-der-waals ICL2 R 181 34x57 G.H5 C 352 G.H5.23
Polar C-term Q 388 - G.s1h1 E 43 G.s1h1.04
Hydrophobic TM3 V 171 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 V 171 3x54 G.H5 I 345 G.H5.16
Polar TM3 A 170 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL3 R 265 - G.S6 Y 321 G.S6.02
Hydrophobic C-term R 384 - G.H2 S 207 G.H2.02
Van-der-waals C-term R 384 - G.H2 S 207 G.H2.02
Hydrophobic ICL2 P 174 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 174 34x50 G.H5 I 345 G.H5.16
Polar TM3 R 167 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 167 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL3 M 266 - G.S6 Y 321 G.S6.02
Hydrophobic TM5 M 257 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 M 257 5x61 G.H5 L 354 G.H5.25
Hydrophobic H8 D 342 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 D 342 8x47 G.H5 G 353 G.H5.24
Polar C-term S 377 - G.H2 K 210 G.H2.05
Hydrophobic C-term S 377 - G.H2 K 210 G.H2.05
Van-der-waals C-term S 377 - G.H2 K 210 G.H2.05
Polar ICL2 R 181 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL2 R 181 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 181 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL3 L 267 - G.H5 F 355 G.H5.26
Polar C-term S 377 - G.H2 E 208 G.H2.03
Hydrophobic C-term S 377 - G.H2 E 208 G.H2.03
Van-der-waals C-term S 377 - G.H2 E 208 G.H2.03
Hydrophobic TM6 M 283 6x36 G.H5 L 354 G.H5.25
Hydrophobic C-term L 389 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term L 389 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 L 178 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 264 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 V 264 5x68 G.H5 D 342 G.H5.13
Polar ICL3 M 266 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 M 266 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 M 266 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 N 276 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 N 276 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM2 T 105 2x39 G.H5 C 352 G.H5.23