Go - μ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 171 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 171 3x54 G.H5 L 348 G.H5.20
Polar C-term D 383 - G.H2 R 209 G.H2.04
Hydrophobic C-term D 383 - G.H2 R 209 G.H2.04
Van-der-waals C-term D 383 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 399 - G.hfs2 V 180 G.hfs2.03
Polar C-term N 386 - G.s3h2 G 203 G.s3h2.01
Aromatic TM6 R 279 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 279 6x32 G.H5 Y 354 G.H5.26
Hydrophobic C-term A 394 - H.HA Q 79 H.HA.17
Van-der-waals C-term A 394 - H.HA Q 79 H.HA.17
Polar ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 283 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 283 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 280 6x33 G.H5 Y 354 G.H5.26
Polar C-term T 385 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 V 175 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term R 384 - G.H2 E 208 G.H2.03
Hydrophobic TM3 R 167 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 E 343 8x48 G.H5 Y 354 G.H5.26
Polar C-term N 371 - G.H3 K 258 G.H3.16
Van-der-waals C-term N 371 - G.H3 K 258 G.H3.16
Polar H8 D 342 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 D 342 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 342 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 264 5x68 G.H5 D 341 G.H5.13
Polar TM6 N 276 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 N 276 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 276 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 L 267 - G.H5 L 348 G.H5.20
Polar C-term S 377 - G.H2 E 208 G.H2.03
Hydrophobic C-term S 377 - G.H2 E 208 G.H2.03
Van-der-waals C-term S 377 - G.H2 E 208 G.H2.03
Ionic ICL2 D 179 34x55 G.hns1 K 32 G.hns1.03
Polar ICL2 D 179 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 D 179 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 D 179 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic C-term H 387 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term H 387 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 L 178 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 178 34x54 G.S3 L 195 G.S3.01
Polar ICL3 R 265 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 265 - G.H5 D 341 G.H5.13
Hydrophobic TM5 M 257 5x61 G.H5 L 348 G.H5.20
Polar C-term N 391 - G.s4h3 H 236 G.s4h3.09
Hydrophobic C-term N 391 - G.s4h3 H 236 G.s4h3.09
Van-der-waals C-term N 391 - G.s4h3 H 236 G.s4h3.09
Hydrophobic ICL3 M 266 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 M 266 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term L 399 - H.HA V 72 H.HA.10
Polar C-term T 385 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic C-term T 385 - G.s3h2 Q 205 G.s3h2.03
Van-der-waals C-term T 385 - G.s3h2 Q 205 G.s3h2.03
Ionic TM5 R 260 5x64 G.H5 D 341 G.H5.13
Polar TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 351 G.H5.23
Polar C-term T 385 - G.H2 S 207 G.H2.02
Van-der-waals C-term T 385 - G.H2 S 207 G.H2.02
Hydrophobic C-term A 394 - H.hbhc D 116 H.hbhc.04
Polar H8 E 343 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 343 8x48 G.H5 G 352 G.H5.24
Ionic C-term E 393 - G.hfs2 R 179 G.hfs2.02
Polar C-term E 393 - G.hfs2 R 179 G.hfs2.02
Hydrophobic C-term E 393 - G.hfs2 R 179 G.hfs2.02
Van-der-waals C-term E 393 - G.hfs2 R 179 G.hfs2.02
Hydrophobic C-term P 400 - H.HA Q 68 H.HA.06
Van-der-waals C-term P 400 - H.HA Q 68 H.HA.06
Hydrophobic ICL3 L 267 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 L 267 - G.H5 Y 354 G.H5.26
Polar C-term S 377 - G.H2 K 210 G.H2.05
Hydrophobic C-term S 377 - G.H2 K 210 G.H2.05
Van-der-waals C-term S 377 - G.H2 K 210 G.H2.05
Hydrophobic ICL3 M 266 - G.H5 A 345 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 A 345 G.H5.17
Polar H8 N 344 8x49 G.H5 R 349 G.H5.21
Van-der-waals H8 N 344 8x49 G.H5 R 349 G.H5.21
Polar TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 347 G.H5.19
Polar C-term Q 388 - G.H2 R 206 G.H2.01
Van-der-waals C-term Q 388 - G.H2 R 206 G.H2.01
Hydrophobic TM5 L 261 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 261 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 105 2x39 G.H5 C 351 G.H5.23
Polar ICL3 M 266 - G.H5 D 341 G.H5.13
Ionic C-term E 390 - G.H2 R 206 G.H2.01
Hydrophobic C-term L 399 - H.HA Y 69 H.HA.07
Hydrophobic ICL2 V 175 34x51 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 V 175 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic C-term T 385 - G.H2 R 209 G.H2.04
Van-der-waals C-term T 385 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 389 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term L 389 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term T 385 - G.H2 W 212 G.H2.07
Hydrophobic TM5 V 264 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 175 34x51 G.H5 F 336 G.H5.08
Hydrophobic C-term R 384 - G.H2 S 207 G.H2.02
Van-der-waals C-term R 384 - G.H2 S 207 G.H2.02
Ionic C-term D 374 - G.H2 K 210 G.H2.05
Van-der-waals H8 N 344 8x49 G.H5 G 352 G.H5.24
Hydrophobic C-term Q 370 - G.H3 K 258 G.H3.16
Van-der-waals C-term Q 370 - G.H3 K 258 G.H3.16
Hydrophobic C-term L 399 - H.HA Q 68 H.HA.06
Van-der-waals C-term L 399 - H.HA Q 68 H.HA.06
Polar ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Polar C-term Q 388 - G.s1h1 E 43 G.s1h1.04
Hydrophobic ICL2 P 174 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 174 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM3 A 170 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 280 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 353 G.H5.25
Ionic TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Polar C-term D 383 - G.H3 S 253 G.H3.11
Hydrophobic C-term T 396 - H.HA S 75 H.HA.13
Van-der-waals C-term T 396 - H.HA S 75 H.HA.13
Polar TM2 T 105 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 T 105 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM5 R 260 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 260 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 171 3x54 G.H5 I 344 G.H5.16
Polar C-term N 386 - G.s1h1 G 42 G.s1h1.03
Hydrophobic C-term N 386 - G.s1h1 G 42 G.s1h1.03
Polar H8 R 347 8x52 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Polar C-term H 375 - G.H2 K 210 G.H2.05
Hydrophobic C-term L 389 - G.s4h3 H 236 G.s4h3.09
Van-der-waals C-term L 389 - G.s4h3 H 236 G.s4h3.09
Hydrophobic TM5 M 257 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 257 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 178 34x54 G.H5 I 343 G.H5.15