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μ receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 174 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 174 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 167 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | P | 400 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | P | 400 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | ICL2 | P | 174 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | P | 174 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | H8 | D | 342 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | D | 342 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | D | 342 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | T | 385 | - | G.H2 | R | 206 | G.H2.01 |
Polar | C-term | T | 385 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Hydrophobic | C-term | T | 385 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Van-der-waals | C-term | T | 385 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Polar | C-term | D | 383 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | D | 383 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | D | 383 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | ICL3 | L | 267 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | L | 267 | - | G.H5 | Y | 354 | G.H5.26 |
Polar | C-term | Q | 388 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | Q | 388 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | Q | 370 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | Q | 370 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM2 | T | 105 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | M | 257 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | M | 257 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | L | 178 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | T | 385 | - | G.H2 | S | 207 | G.H2.02 |
Van-der-waals | C-term | T | 385 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | C-term | L | 399 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | C-term | T | 385 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | ICL3 | L | 267 | - | G.H5 | L | 348 | G.H5.20 |
Ionic | C-term | E | 390 | - | G.H2 | R | 206 | G.H2.01 |
Ionic | C-term | D | 374 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | R | 384 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | A | 394 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | ICL2 | L | 178 | 34x54 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 178 | 34x54 | G.S3 | L | 195 | G.S3.01 |
Polar | TM3 | R | 167 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 167 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | I | 280 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Polar | H8 | E | 343 | 8x48 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | E | 343 | 8x48 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | V | 175 | 34x51 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | V | 175 | 34x51 | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | ICL2 | R | 181 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 181 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | R | 181 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | M | 266 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | M | 266 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | M | 257 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | H | 387 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | H | 387 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | L | 399 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | L | 399 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM6 | M | 283 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 283 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 389 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Van-der-waals | C-term | L | 389 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Ionic | C-term | E | 393 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Polar | C-term | E | 393 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | C-term | E | 393 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Van-der-waals | C-term | E | 393 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | ICL2 | V | 175 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | H8 | E | 343 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | L | 399 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | C-term | H | 375 | - | G.H2 | K | 210 | G.H2.05 |
Polar | H8 | N | 344 | 8x49 | G.H5 | R | 349 | G.H5.21 |
Van-der-waals | H8 | N | 344 | 8x49 | G.H5 | R | 349 | G.H5.21 |
Polar | C-term | N | 386 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Hydrophobic | C-term | N | 386 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Polar | C-term | N | 386 | - | G.s3h2 | G | 203 | G.s3h2.01 |
Ionic | TM5 | R | 260 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Aromatic | TM6 | R | 279 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 279 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Polar | C-term | D | 383 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | T | 385 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | T | 385 | - | G.H2 | R | 209 | G.H2.04 |
Polar | ICL3 | R | 265 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 265 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | I | 280 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 280 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | L | 261 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 261 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | A | 394 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | A | 394 | - | H.HA | Q | 79 | H.HA.17 |
Polar | ICL3 | M | 266 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | V | 171 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 171 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | V | 264 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM2 | T | 105 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 105 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Ionic | ICL2 | D | 179 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | D | 179 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | D | 179 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | D | 179 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | C-term | N | 371 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | N | 371 | - | G.H3 | K | 258 | G.H3.16 |
Polar | TM3 | A | 170 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 170 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 170 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | Q | 388 | - | G.s1h1 | E | 43 | G.s1h1.04 |
Polar | H8 | R | 347 | 8x52 | G.H5 | Y | 354 | G.H5.26 |
Ionic | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 399 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM5 | V | 264 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | M | 266 | - | G.H5 | A | 345 | G.H5.17 |
Van-der-waals | ICL3 | M | 266 | - | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | C-term | R | 384 | - | G.H2 | S | 207 | G.H2.02 |
Van-der-waals | C-term | R | 384 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | ICL2 | P | 174 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | T | 396 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | T | 396 | - | H.HA | S | 75 | H.HA.13 |
Polar | TM6 | N | 276 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | N | 276 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 276 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Polar | C-term | N | 391 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Hydrophobic | C-term | N | 391 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Van-der-waals | C-term | N | 391 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Hydrophobic | TM3 | V | 171 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | S | 377 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | S | 377 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | S | 377 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | S | 377 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | S | 377 | - | G.H2 | E | 208 | G.H2.03 |
Van-der-waals | C-term | S | 377 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | TM5 | R | 260 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 260 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | H8 | N | 344 | 8x49 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | L | 389 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | L | 389 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM3 | A | 170 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | R | 181 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | R | 181 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | R | 181 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | V | 175 | 34x51 | G.S3 | L | 195 | G.S3.01 |