Ggust -
μ receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | ICL2 | R | 181 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | R | 181 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 181 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 181 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | P | 174 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 174 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 167 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | P | 174 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | P | 174 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | H8 | D | 342 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | D | 342 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | L | 389 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL2 | A | 177 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | A | 177 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL3 | R | 265 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | R | 265 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 265 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 265 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | V | 175 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL3 | L | 267 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL3 | L | 267 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | E | 272 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | E | 272 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM4 | T | 182 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | L | 389 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | L | 389 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM2 | T | 105 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL3 | R | 265 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | R | 265 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | R | 265 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | TM5 | M | 257 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | M | 257 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | L | 178 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | E | 393 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | C-term | E | 393 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | E | 393 | - | G.H3 | Y | 258 | G.H3.17 |
Ionic | C-term | E | 395 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | E | 395 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | E | 395 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL3 | L | 267 | - | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | D | 166 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | L | 392 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL3 | M | 266 | - | G.S5 | S | 263 | G.S5.01 |
Van-der-waals | ICL3 | M | 266 | - | G.S5 | S | 263 | G.S5.01 |
Polar | TM3 | R | 167 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 167 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 167 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | I | 280 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Polar | H8 | E | 343 | 8x48 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | E | 343 | 8x48 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | V | 175 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | ICL2 | R | 181 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 181 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | R | 181 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | M | 266 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 392 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | ICL2 | L | 178 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 178 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | M | 257 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | M | 266 | - | G.H5 | I | 342 | G.H5.14 |
Van-der-waals | ICL3 | M | 266 | - | G.H5 | I | 342 | G.H5.14 |
Polar | TM6 | R | 279 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | R | 279 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | M | 283 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 283 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | V | 175 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | H8 | E | 343 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | K | 273 | 6x26 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 273 | 6x26 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 273 | 6x26 | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | H8 | N | 344 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | N | 344 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | ICL2 | L | 178 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 178 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 389 | - | G.H3 | I | 253 | G.H3.12 |
Ionic | TM5 | R | 260 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 260 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 260 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 265 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 265 | - | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | K | 273 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | K | 273 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | I | 280 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 280 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | L | 261 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | R | 265 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | R | 265 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL3 | M | 266 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | M | 266 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | V | 171 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | V | 264 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | V | 264 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | L | 392 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | L | 392 | - | G.H2 | K | 209 | G.H2.05 |
Polar | TM2 | T | 105 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | T | 105 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 105 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Ionic | ICL2 | D | 179 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | D | 179 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | D | 179 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | D | 179 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | L | 389 | - | G.H3 | H | 256 | G.H3.15 |
Polar | TM3 | A | 170 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 170 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 170 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL3 | R | 265 | - | G.S6 | S | 321 | G.S6.03 |
Polar | ICL3 | M | 266 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | M | 266 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | M | 266 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | H8 | R | 347 | 8x52 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | R | 347 | 8x52 | G.H5 | F | 354 | G.H5.26 |
Ionic | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 273 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | V | 264 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | M | 266 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | M | 266 | - | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | P | 174 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 174 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | N | 276 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 276 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | V | 171 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | V | 171 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | E | 393 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | E | 393 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | E | 393 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | E | 393 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM5 | R | 260 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 260 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | H8 | N | 344 | 8x49 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | A | 170 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 178 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | R | 181 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | R | 181 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | R | 181 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | Q | 388 | - | G.H2 | R | 208 | G.H2.04 |