GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 16.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL1 | K | 60 | 12x48 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM5 | V | 227 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | V | 227 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | H8 | Q | 306 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | Q | 306 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | N | 304 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 304 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 304 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | V | 244 | 6x33 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | R | 141 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | R | 141 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | R | 141 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | L | 66 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | L | 66 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 133 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM1 | L | 57 | 1x58 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | L | 57 | 1x58 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM5 | V | 227 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | V | 227 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | C-term | Q | 330 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | Q | 330 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | Q | 330 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | S | 324 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 133 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | V | 244 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL1 | R | 63 | 12x51 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ICL1 | R | 63 | 12x51 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM6 | A | 240 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | N | 345 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Van-der-waals | C-term | N | 345 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Polar | H8 | K | 305 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | K | 305 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | K | 305 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | S | 328 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | S | 328 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM6 | E | 243 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | E | 243 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | S | 335 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | S | 335 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | TM1 | R | 58 | 1x59 | G.HN | M | 1 | G.HN.01 |
Polar | TM3 | V | 132 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | V | 132 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | V | 132 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Polar | TM3 | R | 129 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 129 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 129 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 129 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 129 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | V | 248 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | A | 240 | 6x29 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | N | 370 | G.H5.19 |
Polar | TM5 | Q | 231 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | Q | 231 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | Q | 231 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | L | 224 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 224 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | V | 244 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | M | 247 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 247 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | K | 305 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | K | 305 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | K | 305 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | K | 135 | 3x56 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | TM3 | K | 135 | 3x56 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM3 | V | 132 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | V | 132 | 3x53 | G.H5 | L | 374 | G.H5.23 |