Go - oxoglutarate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 139 34x51 G.H5 I 343 G.H5.15
Ionic TM6 K 236 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 236 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 236 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 236 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 239 6x33 G.H5 L 348 G.H5.20
Polar TM2 S 68 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM3 I 135 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL3 Q 230 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 Q 230 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 Q 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 230 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 V 305 7x56 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 142 34x54 G.hns1 K 32 G.hns1.03
Polar TM6 S 233 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 233 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 233 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 A 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic H8 D 307 8x48 G.H5 R 349 G.H5.21
Polar TM3 V 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 235 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 L 235 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 142 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 135 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 135 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 235 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 229 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 M 139 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 M 139 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 S 143 34x55 G.HN I 28 G.HN.52
Hydrophobic ICL3 L 229 - G.H5 A 338 G.H5.10
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.25
Polar ICL3 Q 230 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 Q 230 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 L 229 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 229 - G.H5 D 337 G.H5.09
Hydrophobic TM3 F 127 3x46 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 127 3x46 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 138 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 246 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 139 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 139 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 138 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 F 142 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 142 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM4 K 146 4x38 G.HN I 28 G.HN.52
Van-der-waals TM4 K 146 4x38 G.HN I 28 G.HN.52
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM7 V 305 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 305 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 M 139 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 M 139 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 138 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 131 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 131 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 F 130 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 235 6x29 G.H5 A 345 G.H5.17
Van-der-waals TM6 L 235 6x29 G.H5 A 345 G.H5.17
Hydrophobic TM6 T 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 225 5x65 G.H5 I 344 G.H5.16
Polar TM6 K 238 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 238 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM3 V 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 225 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 242 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 242 6x36 G.H5 G 352 G.H5.24
Polar ICL3 L 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 229 - G.H5 D 341 G.H5.13
Hydrophobic TM6 L 242 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 221 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM7 V 304 7x55 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 304 7x55 G.H5 G 352 G.H5.24
Ionic TM6 K 236 6x30 G.h4s6 E 318 G.h4s6.12