G12 - OT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 L 74 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 141 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL3 V 260 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 V 260 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 A 269 6x29 G.H5 L 380 G.H5.25
Polar C-term N 367 - G.H3 K 284 G.H3.16
Van-der-waals C-term N 367 - G.H3 K 284 G.H3.16
Polar TM2 S 72 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 S 72 2x37 G.H5 Q 381 G.H5.26
Polar TM5 N 230 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 N 230 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 T 273 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 273 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 257 - G.S6 F 350 G.S6.05
Hydrophobic H8 H 335 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 H 335 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM2 F 75 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 F 75 2x40 G.H5 Q 381 G.H5.26
Polar ICL2 P 144 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 145 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 145 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 L 145 - G.S1 V 58 G.S1.02
Hydrophobic ICL2 P 144 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 144 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 R 259 - G.S6 H 349 G.S6.04
Hydrophobic H8 T 333 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 T 333 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 R 259 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 A 256 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 A 256 - G.H4 R 329 G.H4.09
Polar ICL3 A 256 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 A 256 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 A 256 - G.H4 Q 333 G.H4.13
Polar TM6 R 272 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 272 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 272 6x32 G.H5 M 379 G.H5.24
Polar TM3 A 140 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 145 - G.H5 K 367 G.H5.12
Polar ICL3 L 257 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 L 257 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 V 260 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 V 260 - G.S6 F 347 G.S6.02
Ionic TM5 K 234 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 234 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 234 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 234 5x72 G.H5 D 368 G.H5.13
Polar ICL2 S 147 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 147 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 147 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 144 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 E 242 - G.H4 E 325 G.H4.05
Van-der-waals ICL3 E 242 - G.H4 E 325 G.H4.05
Ionic ICL3 E 242 - G.H4 R 323 G.H4.03
Polar ICL3 E 242 - G.H4 R 323 G.H4.03
Van-der-waals ICL3 V 260 - G.S6 L 346 G.S6.01
Polar ICL3 R 259 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 R 259 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 R 259 - G.S6 H 348 G.S6.03
Polar TM6 R 272 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 272 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 A 243 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 A 243 - G.H4 R 329 G.H4.09
Hydrophobic TM6 L 265 6x25 G.H5 K 376 G.H5.21
Van-der-waals TM6 L 265 6x25 G.H5 K 376 G.H5.21
Polar ICL3 A 256 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 A 256 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 A 256 - G.S6 H 348 G.S6.03
Hydrophobic TM4 R 149 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 R 149 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 145 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 145 - G.H5 I 370 G.H5.15
Polar TM3 R 137 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 257 - G.H4 Q 328 G.H4.08
Hydrophobic TM4 R 149 4x38 G.HN R 52 G.HN.52
Polar C-term S 366 - G.H3 K 284 G.H3.16
Van-der-waals TM7 F 332 7x56 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 L 257 - G.H4 R 329 G.H4.09
Hydrophobic TM5 N 230 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 N 230 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 R 259 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 R 259 - G.S6 F 347 G.S6.02
Hydrophobic TM3 I 141 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 257 - G.H4 V 332 G.H4.12
Hydrophobic TM3 A 140 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 M 276 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 276 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM2 S 72 2x37 G.H5 D 377 G.H5.22
Polar ICL3 S 261 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 S 261 - G.h4s6 R 339 G.h4s6.08
Hydrophobic TM3 I 141 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 223 5x61 G.H5 M 379 G.H5.24
Polar ICL3 S 261 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 S 261 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 261 - G.S6 L 346 G.S6.01
Polar H8 G 334 8x48 G.H5 Q 381 G.H5.26
Polar TM6 R 272 6x32 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 272 6x32 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 272 6x32 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 269 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 265 6x25 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 145 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 145 - G.S3 I 221 G.S3.01
Hydrophobic ICL3 L 257 - G.H4 E 325 G.H4.05
Hydrophobic TM5 I 227 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 227 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 S 262 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 A 256 - G.H4 V 332 G.H4.12
Polar ICL3 A 258 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 A 258 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 A 258 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 144 - G.H5 L 371 G.H5.16
Hydrophobic TM6 K 268 6x28 G.H5 L 380 G.H5.25