G15 - OT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 272 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM6 R 272 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 R 272 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM2 L 74 2x39 G.H5 I 371 G.H5.23
Hydrophobic TM4 R 151 4x40 G.HN L 33 G.HN.48
Van-der-waals TM4 R 151 4x40 G.HN L 33 G.HN.48
Hydrophobic TM6 A 269 6x29 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 145 - G.H5 V 359 G.H5.11
Hydrophobic TM6 R 272 6x32 G.H5 L 373 G.H5.25
Hydrophobic ICL2 P 144 - G.H5 L 364 G.H5.16
Hydrophobic TM6 T 273 6x33 G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 145 - G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 145 - G.S1 L 43 G.S1.02
Hydrophobic ICL3 A 243 - G.H4 R 310 G.H4.09
Hydrophobic C-term S 368 - G.H3 W 266 G.H3.17
Van-der-waals C-term S 368 - G.H3 W 266 G.H3.17
Hydrophobic ICL2 P 144 - G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 144 - G.H5 V 363 G.H5.15
Hydrophobic TM3 I 141 3x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 P 144 - G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 144 - G.H5 R 360 G.H5.12
Hydrophobic TM3 I 141 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM4 R 149 4x38 G.HN K 37 G.HN.52
Van-der-waals TM4 R 149 4x38 G.HN K 37 G.HN.52
Hydrophobic TM3 I 141 3x54 G.H5 L 368 G.H5.20
Hydrophobic C-term L 373 - G.H2 R 216 G.H2.04
Hydrophobic TM6 I 266 6x26 G.h4s6 R 338 G.h4s6.20
Polar TM7 F 332 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM7 F 332 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 F 332 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM5 N 230 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM6 L 265 6x25 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 145 - G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 145 - G.H5 F 356 G.H5.08
Hydrophobic TM6 M 276 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM5 I 227 5x65 G.H5 L 373 G.H5.25
Ionic ICL3 E 242 - G.H4 R 310 G.H4.09
Van-der-waals H8 G 334 8x48 G.H5 N 372 G.H5.24
Hydrophobic TM3 I 141 3x54 G.H5 I 371 G.H5.23
Polar TM5 N 230 5x68 G.H5 D 361 G.H5.13
Hydrophobic ICL2 L 145 - G.S3 T 202 G.S3.01
Ionic C-term H 375 - G.H3 E 253 G.H3.04
Polar TM6 R 272 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 R 272 6x32 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 145 - G.H5 V 363 G.H5.15
Polar TM2 S 72 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM2 S 72 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 S 72 2x37 G.H5 E 370 G.H5.22
Polar H8 T 333 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 T 333 8x47 G.H5 N 372 G.H5.24
Hydrophobic C-term L 373 - G.H3 T 260 G.H3.11
Van-der-waals C-term L 373 - G.H3 T 260 G.H3.11
Polar ICL3 A 256 - G.S6 S 341 G.S6.03
Hydrophobic ICL3 A 256 - G.H4 L 313 G.H4.12
Van-der-waals ICL3 A 256 - G.H4 L 313 G.H4.12
Hydrophobic TM3 A 140 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 Y 367 G.H5.19
Polar TM6 A 269 6x29 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 269 6x29 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 269 6x29 G.H5 L 373 G.H5.25
Hydrophobic TM5 I 227 5x65 G.H5 L 368 G.H5.20
Ionic TM5 K 234 5x72 G.H5 D 361 G.H5.13
Polar TM5 K 234 5x72 G.H5 D 361 G.H5.13
Hydrophobic TM5 K 234 5x72 G.H5 D 361 G.H5.13
Van-der-waals TM5 K 234 5x72 G.H5 D 361 G.H5.13
Hydrophobic ICL2 L 145 - G.H5 R 360 G.H5.12