Gi2 - P2Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM7 A 309 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 A 309 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 A 309 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 142 34x54 G.hns1 R 32 G.hns1.03
Polar TM6 S 243 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 243 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 243 6x34 G.H5 L 354 G.H5.25
Hydrophobic C-term L 377 - G.H3 L 250 G.H3.08
Hydrophobic C-term D 374 - G.H2 E 208 G.H2.03
Van-der-waals C-term D 374 - G.H2 E 208 G.H2.03
Polar C-term I 375 - G.H2 R 209 G.H2.04
Hydrophobic C-term I 375 - G.H2 R 209 G.H2.04
Van-der-waals C-term I 375 - G.H2 R 209 G.H2.04
Polar TM6 T 246 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 246 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 138 34x50 G.H5 I 345 G.H5.16
Polar TM6 K 242 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 242 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 242 6x33 G.H5 F 355 G.H5.26
Ionic C-term E 370 - G.H3 K 249 G.H3.07
Polar C-term E 370 - G.H3 K 249 G.H3.07
Van-der-waals C-term E 370 - G.H3 K 249 G.H3.07
Hydrophobic TM3 R 131 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 354 G.H5.25
Ionic ICL2 R 143 34x55 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 143 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 R 143 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 143 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 L 142 34x54 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 142 34x54 G.H5 I 344 G.H5.15
Hydrophobic C-term I 375 - G.H3 K 249 G.H3.07
Hydrophobic C-term I 375 - G.H3 L 250 G.H3.08
Hydrophobic C-term I 375 - G.H3 E 246 G.H3.04
Van-der-waals C-term I 375 - G.H3 E 246 G.H3.04
Ionic TM6 R 238 6x29 G.h4s6 D 316 G.h4s6.09
Polar TM6 R 238 6x29 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 R 238 6x29 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 R 238 6x29 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM3 V 135 3x54 G.H5 I 345 G.H5.16
Ionic H8 R 315 8x52 G.h3s5 D 262 G.h3s5.02
Polar H8 R 315 8x52 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 R 315 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic C-term R 376 - G.H2 R 206 G.H2.01
Van-der-waals C-term R 376 - G.H2 R 206 G.H2.01
Hydrophobic C-term L 377 - G.H2 W 212 G.H2.07
Van-der-waals C-term L 377 - G.H2 W 212 G.H2.07
Hydrophobic TM5 L 225 5x65 G.H5 L 349 G.H5.20
Ionic TM4 R 146 4x38 G.HN E 28 G.HN.52
Polar TM4 R 146 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 146 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 146 4x38 G.HN E 28 G.HN.52
Polar TM2 S 68 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL2 P 138 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 M 221 5x61 G.H5 L 349 G.H5.20
Hydrophobic C-term L 377 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 377 - G.H2 R 209 G.H2.04
Ionic H8 R 312 8x49 G.H5 D 351 G.H5.22
Polar H8 R 312 8x49 G.H5 D 351 G.H5.22
Hydrophobic H8 R 312 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 R 312 8x49 G.H5 D 351 G.H5.22
Hydrophobic TM3 V 135 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM4 R 146 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 R 146 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 A 309 7x56 G.H5 C 352 G.H5.23
Ionic TM6 K 240 6x31 G.H5 D 342 G.H5.13
Polar TM6 K 240 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 K 240 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 V 250 6x41 G.H5 L 354 G.H5.25
Polar ICL2 S 141 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 S 141 34x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 139 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 139 34x51 G.S3 L 195 G.S3.01
Van-der-waals TM6 P 237 6x28 G.h4s6 E 319 G.h4s6.12
Polar TM3 R 131 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 352 G.H5.23
Ionic C-term D 374 - G.H2 R 209 G.H2.04
Polar C-term D 374 - G.H2 R 209 G.H2.04
Hydrophobic C-term D 374 - G.H2 R 209 G.H2.04
Van-der-waals C-term D 374 - G.H2 R 209 G.H2.04
Hydrophobic TM5 M 221 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 M 221 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL3 T 232 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 T 232 - G.h4s6 E 319 G.h4s6.12
Ionic C-term R 376 - G.s4h3 E 237 G.s4h3.10
Polar C-term R 376 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term R 376 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term R 376 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM5 L 225 5x65 G.H5 I 345 G.H5.16
Hydrophobic C-term L 377 - G.s3h2 G 203 G.s3h2.01
Hydrophobic TM5 A 229 5x69 G.H5 D 342 G.H5.13
Van-der-waals TM5 A 229 5x69 G.H5 D 342 G.H5.13
Hydrophobic C-term L 377 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term L 377 - G.s1h1 G 40 G.s1h1.01
Polar C-term R 376 - G.s1h1 G 42 G.s1h1.03
Hydrophobic C-term L 377 - G.H1 K 46 G.H1.01
Van-der-waals C-term L 377 - G.H1 K 46 G.H1.01
Hydrophobic TM6 S 243 6x34 G.H5 L 349 G.H5.20
Polar TM3 G 134 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 134 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 134 3x53 G.H5 N 348 G.H5.19
Polar C-term L 377 - G.s3h2 G 204 G.s3h2.02
Van-der-waals C-term L 377 - G.s3h2 G 204 G.s3h2.02
Hydrophobic ICL2 P 138 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 138 34x50 G.H5 T 341 G.H5.12
Hydrophobic H8 Q 311 8x48 G.H5 K 350 G.H5.21
Hydrophobic TM6 A 239 6x30 G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 139 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 139 34x51 G.H5 F 337 G.H5.08
Hydrophobic C-term L 377 - G.S1 L 39 G.S1.07
Hydrophobic ICL2 R 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 H 130 3x49 G.H5 C 352 G.H5.23
Hydrophobic TM6 I 247 6x38 G.H5 L 354 G.H5.25